JAMA Network Open@JAMANetworkOpen

JAMA Network Open is a member of the JAMA Network, a consortium of peer-reviewed, general medical and specialty publications.

 Chicago, IL
jamanetworkopen.com
Joined April 2017
5,181 Photos and videos
In 2027, JAMA will convene leaders across #medicine, research, #technology, industry, and #policy to address how #AI will reshape health care and biomedical science. Learn more: ja.ma/4BHTvYI #HealthAfterAI #JAMASummit
260
馃摑 Thinking about submitting your #KidneyWk research to @JAMA_current, @JAMAInternalMed, @JAMANetworkOpen, or one of our other Network journals? This video tells you what to expect from the submission and review process. ja.ma/4eolQcm

How to Submit Your Research Paper to the JAMA Network

Ever wonder what happens to your manuscript after you submit it? Fr...

youtube.com
1
1
5
1,646
馃摚 JAMA and the JAMA Network journals are issuing a call for papers on Women's Health. 鉃★笍 Manuscripts submitted by November 15, 2026, will have the best chance for consideration for simultaneous publication on International Women鈥檚 Day. 馃敆 Learn more: ja.ma/4zQ2NAa
2
590
馃帀 Attending #KidneyWk? Check out our page created for attendees. Read articles presented at the meeting, and get information For Authors on @JAMA_current, @JAMAInternalMed, and @JAMANetworkOpen. ja.ma/4ATjzzD
1
750
Higher baseline anxiety and potentially cancer diagnostic tests were associated with increased anxiety after immediate #LaboratoryTesting result release, supporting more individualized patient support. ja.ma/4jykFdZ
A flow chart titled 'Baseline anxiety' on the left and 'Change after viewing' on the right. Baseline shows: Extremely worried 2.8%, Very worried 4.9%, Somewhat worried 19.3%, A little worried 28.9%, Not at all 44.0%. Change shows: Increased 4.6%, No change 37.8%, Decreased 57.6%.

ALT A flow chart titled 'Baseline anxiety' on the left and 'Change after viewing' on the right. Baseline shows: Extremely worried 2.8%, Very worried 4.9%, Somewhat worried 19.3%, A little worried 28.9%, Not at all 44.0%. Change shows: Increased 4.6%, No change 37.8%, Decreased 57.6%.
1
649
Among females in Japan, #ADHD showed a childhood peak and a second young adult peak, indicating changing recognition of diagnoses across the life course. ja.ma/4k6W2oP
Four line graphs (A-D) show rising incidence proportions per 100,000 population from 2010 to 2023 for ASD, ADHD, and ASD+ADHD. Graphs A and B show ages 0-19 years for males and females; C and D show ages \u226520 years for males and females.

ALT Four line graphs (A-D) show rising incidence proportions per 100,000 population from 2010 to 2023 for ASD, ADHD, and ASD+ADHD. Graphs A and B show ages 0-19 years for males and females; C and D show ages \u226520 years for males and females.
1
480
Systematic review: Trials of therapeutic #Psilocybin focused mainly on depression, but media reports often extended potential benefits to anxiety and posttraumatic stress disorder despite limited or no trial evidence. ja.ma/4i7h1p1
A bar chart compares the number of clinical trials (blue) and media articles (orange) from 2014 to 2025. Both categories show a general increase over time, peaking around 2022 to 2024, with media articles consistently outnumbering clinical trials.

ALT A bar chart compares the number of clinical trials (blue) and media articles (orange) from 2014 to 2025. Both categories show a general increase over time, peaking around 2022 to 2024, with media articles consistently outnumbering clinical trials.

2
3
602
For cisplatin-ineligible muscle-invasive #BladderCancer, perioperative #EnfortumabVedotin plus pembrolizumab with radical cystectomy was associated with improved survival and was cost-effective vs radical cystectomy alone over 10 years. ja.ma/4seltqJ
Line graph showing the probability of being the preferred strategy versus the willingness-to-pay threshold in thousands of dollars per QALY. The intervention curve rises, while the control curve declines, intersecting near 100 thousand.

ALT Line graph showing the probability of being the preferred strategy versus the willingness-to-pay threshold in thousands of dollars per QALY. The intervention curve rises, while the control curve declines, intersecting near 100 thousand.
4
6
2,242
After emergency department discharge for acute pain, many patients had unused #Opioids at 2 weeks and 3 months, supporting more tailored prescribing and safer disposal strategies. ja.ma/4e8194H
Table 3 details opioid disposal 3 months post-ED discharge, showing 61.9% still have unused opioids (mostly for future pain), 49.7% used leftovers, and 33.5% would return them if asked.

ALT Table 3 details opioid disposal 3 months post-ED discharge, showing 61.9% still have unused opioids (mostly for future pain), 49.7% used leftovers, and 33.5% would return them if asked.
1
5
692
Among pregnant women, all identified social vulnerability profiles were associated with inadequate #CervicalCancer screening, with the greatest disadvantage in those with migrant or linguistic barriers. ja.ma/3WlYQER
A forest plot displaying Adjusted Odds Ratios (AOR) with 95% confidence intervals for five social vulnerabilities: substance use/psychological (2.05), migrant/linguistic barrier (0.97), psychological violence (2.21), sexual violence (1.95), and physical violence (2.40).

ALT A forest plot displaying Adjusted Odds Ratios (AOR) with 95% confidence intervals for five social vulnerabilities: substance use/psychological (2.05), migrant/linguistic barrier (0.97), psychological violence (2.21), sexual violence (1.95), and physical violence (2.40).
1
562
In advanced #UrothelialCarcinoma, treatment-emergent skin toxic effects during first-line enfortumab vedotin plus pembrolizumab were associated with longer overall survival. ja.ma/4k88Qvf
A horizontal bar chart showing time since EVP indication in months on the x-axis, accompanied by categorical side columns for skin toxic effects, best response, and vital status. Below is a density plot peaking sharply near zero.

ALT A horizontal bar chart showing time since EVP indication in months on the x-axis, accompanied by categorical side columns for skin toxic effects, best response, and vital status. Below is a density plot peaking sharply near zero.

1
3
14
3,485
For metastatic hormone-sensitive #ProstateCancer, next-generation androgen receptor inhibitors were associated with longer overall survival than an androgen synthesis inhibitor in US clinical practice. ja.ma/3VZNWo7
Kaplan-Meier survival curve comparing ASI and ARI treatments over 132 months. The y-axis shows overall survival probability (0-100%), and the x-axis shows time in months. ARI (orange) shows higher survival probability than ASI (grey). Adjusted HR = 0.74, P < .001.

ALT Kaplan-Meier survival curve comparing ASI and ARI treatments over 132 months. The y-axis shows overall survival probability (0-100%), and the x-axis shows time in months. ARI (orange) shows higher survival probability than ASI (grey). Adjusted HR = 0.74, P < .001.

1
1
813
For eligible adults, #ColorectalCancer screening nonadherence was also associated with being uninsured and lacking a usual source of care, indicating persistent access barriers after guideline expansion. ja.ma/4jvfg7t
Table showing Adjusted Prevalence of Colorectal Cancer Screening Nonadherence by Nativity and Duration of US Residence across insurance status, care source, and age groups, detailing percentages and 95% confidence intervals.

ALT Table showing Adjusted Prevalence of Colorectal Cancer Screening Nonadherence by Nativity and Duration of US Residence across insurance status, care source, and age groups, detailing percentages and 95% confidence intervals.

1
2
4
813
Patients with #IntracerebralHemorrhage arrived faster than those with #AcuteIschemicStroke, but after adjustment were less likely to meet emergency department care targets. ja.ma/4ySeG8F
Three line graphs from 2015 to 2024 comparing ischemic stroke and intracerebral hemorrhage. (A) shows increasing last-known-well to arrival time. (B) shows stable symptom onset to ED arrival time. (C) shows steady EMS prenotification percentages.

ALT Three line graphs from 2015 to 2024 comparing ischemic stroke and intracerebral hemorrhage. (A) shows increasing last-known-well to arrival time. (B) shows stable symptom onset to ED arrival time. (C) shows steady EMS prenotification percentages.
2
2
464
For opioid-naive adults with Medicaid coverage and #AcuteLowBackPain, #Chiropractic care and physical therapy were associated with lower risk of subsequent #OpioidUseDisorder or overdose than pharmacologic treatment. ja.ma/4yyokfR
Two horizontal bar charts comparing pain treatments' relative risk at 12 months (A) and 6 months (B) follow-ups. Opioid >50 MME/d shows the highest relative risk in both, while chiropractic and physical therapy show negative relative risks.

ALT Two horizontal bar charts comparing pain treatments' relative risk at 12 months (A) and 6 months (B) follow-ups. Opioid >50 MME/d shows the highest relative risk in both, while chiropractic and physical therapy show negative relative risks.
4
8
808
During a severe #Chemotherapy shortage, more than 1 in 4 carboplatin allocation decisions at a multisite health system were not aligned with policy intent, chiefly because of incomplete documentation. ja.ma/4sbnggj
A Sankey diagram displaying data flow across three columns. The left column shows categories 1-5 and Missing. The middle column divides into Received carboplatin and Did not receive carboplatin. The right column shows outcomes I-V.

ALT A Sankey diagram displaying data flow across three columns. The left column shows categories 1-5 and Missing. The middle column divides into Received carboplatin and Did not receive carboplatin. The right column shows outcomes I-V.
3
3
741
This systematic review and meta-analysis of 19 studies found #ADHD was associated with increased mortality from all causes, suicide, accidents/injuries and natural causes; ADHD medication use was associated with lower mortality. ja.ma/4BeDxoE
A JAMA Network Open article titled \"Mortality Among People With Attention-Deficit/Hyperactivity Disorder: A Systematic Review and Meta-Analysis\" by Lucy Corrigan et al, published October 19, 2026.

ALT A JAMA Network Open article titled \"Mortality Among People With Attention-Deficit/Hyperactivity Disorder: A Systematic Review and Meta-Analysis\" by Lucy Corrigan et al, published October 19, 2026.

1
2
11
995
In this RCT of adults with #depression, a home-based intervention combining transcranial direct current stimulation (#tDCS) with gamified cognitive control training was feasible and safe, but did not show greater efficacy than sham control. ja.ma/4zG14NB
Three charts. A: Histograms for control and active groups showing distribution of completed treatment sessions. B: Frequency of completed treatments. C: Line graph showing MADRS score by treatment week for control and active groups.

ALT Three charts. A: Histograms for control and active groups showing distribution of completed treatment sessions. B: Frequency of completed treatments. C: Line graph showing MADRS score by treatment week for control and active groups.
2
3
513
Among adults with #OCD, the Bergen 4-Day Treatment was more effective than internet-based cognitive behavioral therapy (#CBT) in reducing severity of OCD and improving secondary outcomes, with benefits maintained at 3-month follow-up. ja.ma/481gKzj
An infographic from JAMA Network Open summarizing an RCT comparing B4DT and iCBT for OCD. It details a population of 40 men and 79 women, a 3-month follow-up showing significantly greater symptom reduction for the B4DT group, and settings in Germany.

ALT An infographic from JAMA Network Open summarizing an RCT comparing B4DT and iCBT for OCD. It details a population of 40 men and 79 women, a 3-month follow-up showing significantly greater symptom reduction for the B4DT group, and settings in Germany.
2
2
519
In this cluster RCT of patients with type 2 #diabetes, an agenda-setting kit did not improve illness intrusiveness, treatment burden, diabetes distress, or HbA1c at 6 months compared with usual care alone; however, patient medication adherence increased. ja.ma/4yynJuD
A JAMA Network Open article titled 'A Conversation Tool to Enhance Care for People With Type 2 Diabetes: The QBSafe Cluster Randomized Clinical Trial,' by Kasia J. Lipska, MD, et al., published October 19, 2026.

ALT A JAMA Network Open article titled 'A Conversation Tool to Enhance Care for People With Type 2 Diabetes: The QBSafe Cluster Randomized Clinical Trial,' by Kasia J. Lipska, MD, et al., published October 19, 2026.

1
2
2
657
Load more