Director @AmgenOncology, ❤️ @JohnsHopkinsMBG
Thousand Oaks, CA
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Excited to share a new Perspective published today in @NatureCellBio, written with Colin Gliech
In this piece, we discuss how cells leverage biological “clocks” during mitosis to protect genome integrity—a fascinating layer of regulation in cell division.
nature.com/articles/s41556-0…
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Interested in E3-Ub ligase regulation? Check out the latest paper from our lab: nature.com/articles/s41594-0…. Big congrats to @PeterYeowZY who conceived and drove this study!
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Also, check out the accompanying paper from the @oegemadesai_lab nature.com/articles/s41594-0…
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Centriole structural integrity defects are a crucial feature of hydrolethalus syndrome, say Ana Curinha (@ana_curinha), Andrew Holland @AHollandLab @JohnsHopkins and colleagues: hubs.la/Q038zmjt0
#Centrioles #Cilia
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Check out our latest work using the AID2 system to control the levels of an essential protein in mice. Congrats to the entire team, especially @SladkyValentina and Margaret Strong
science.org/doi/10.1126/scia…
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Check out our latest paper in @JCellBiol. Congrats to the entire team, especially @ana_curinha
HLS, an autosomal recessive #ciliopathy, is associated with a mutation in the centriole protein HYLS1. Curinha, Holland et al @JohnsHopkins show that HYLS1 mutant mice exhibit developmental abnormalities, with #centriole integrity & #cilia assembly defects hubs.la/Q038p3mr0
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Andrew Holland retweeted
BREAKING: Johns Hopkins along with 12 peer institutions and Assoc of Amer Univ sues to stop drastic cuts in NIH funding. This is separate from lawsuit brought by 22 states, which also includes Maryland. Hopkins prez cites our 600 clinical trials that would be crippled by the cut.
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Things I wish more people knew about doing science in the US (thread):
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Curious about how cells generate mechanically stiff invasive protrusions from branched actin filaments? Check out our paper published today in @NatureCellBio!
Congratulations to Yue Lu and all co-authors for a beautiful piece of work!
nature.com/articles/s41556-0…
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Andrew Holland retweeted
Mesoscale regulation of MTOCs by the E3 ligase TRIM37 dlvr.it/TFRbdj
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Full preprint here: biorxiv.org/content/10.1101/… we welcome feedback and questions, thanks! 🙏
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📝Preprint! 1️⃣Question: How are large MTOC structures regulated by an E3 ligase? 🧵In 2020, we showed TRIM37 suppresses surrogate MTOC structures in 17q23 cancers, see ⬇️). But TRIM37 also regulates centrosomes and pathological MTOCs (Gönczy/Oegema/Desai labs). How?? ➡️our model
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2️⃣ Model: My work at @ahollandlab suggests a shared blueprint within the TRIM family for assembly regulation. Akin to TRIM5a in HIV restriction, TRIM37 employs an assembly-driven E3 activation process but is uniquely tailored for MTOC control via its TRAF domain. ➡️Impact
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Andrew Holland retweeted
Today's @US_FDA decision to expand use of Bispecific T-cell Engager (BiTE®) immunotherapy to adult patients receiving front-line B-ALL therapy is a major milestone in the care of leukemia patients. As a hematologist who cared for patients with ALL just prior to joining @Amgen, I am well calibrated to the chance this medicine and regimen has to change the outcome for so many fighting this disease. Bravo. #MyCompany
We’re proud to announce that the @US_FDA has approved Amgen’s BiTE® immunotherapy for the treatment of CD19-positive Ph-negative B-cell precursor acute lymphoblastic leukemia (B-ALL) in the consolidation phase.
🔗 Press release: amgen.ly/4ciz0nY
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