ALT A large data base of colonoscopies was analysed for mast cells. The data do not show a relationship between diarrhoea and elevated mast cells in the colonic mucosa. This study provides real-world evidence against the routine diagnostic use of colonic mast cell quantification for the evaluation of diarrhoea.

ALT Among 11,387 patients with acute gastrointestinal bleeding, overlap-weighted analyses (n = 10,044) found no statistically significant association between direct oral anticoagulant or warfarin use and 30-day or 1-year mortality. Haemodynamic shock was associated with 30-day mortality, whereas age and Internal Medicine ward admission were associated with mortality at both time points. Anticoagulation was resumed at discharge in 38% of survivors.

ALT This multicentre prospective cohort found an 84% persistence of subcutaneous vedolizumab 1 year after switching from intravenous vedolizumab in patients with IBD in remission; two thirds of patients remained in sustained remission. Vedolizumab drug levels were not associated with treatment persistence.