News and views from the world of clinical oncology and hematology
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🏡Improved survival in #PediatricLeukemia does not eliminate the burden on families.
A new study underscores the need for early, ongoing caregiver support, routine screening for financial toxicity and household disruptions.
▪️Dr. Rozalyn Rodwin | @JNCCN
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📊Two @AmericanCancer studies presented at #ASCOQLTY26 found widening #BreastCancer survival and mortality disparities over time between rural and urban communities, highlighting persistent gaps in access to cancer care.
Explore the findings ➡️ ascopost.com/news/october-20…
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🩻 #ASCOAI: Could #AI help improve radiation oncology training?
A randomized phase II trial found that AI auto-segmentation improved contour quality and efficiency among novice practitioners performing #ProstateCancer brachytherapy.
Learn more 👉 ascoai.org/articles/2026/10/…
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2️⃣ studies highlight emerging therapies for AL #Amyloidosis.
Anselamimab showed a survival signal in prespecified subgroup, while linvoseltamab demonstrated deep hematologic and organ responses in early-phase research.
🔹Drs. Wechalekar & Lee | #ASCO26
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🚨 #FDAApproval: The @FDA has granted accelerated approval to dostarlimab (Jemperli) for adults with stage II/III MSI-H/dMMR locally advanced #RectalCancer.
In AZUR-1, the ORR was 79%, with a 47% sustained clinical CR rate at 12 months.
🔗 ascopost.com/news/october-20…
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🩸In the phase III EXCALIBER-RRMM trial, iberdomide + daratumumab + dexamethasone improvedMRD-negative CR rates vs the bortezomib-based regimen (41% vs 21%) in patients with relapsed/refractory #MultipleMyeloma.
🔸@SagarLonialMD | @TheLancetOncol
🔗 ascopost.com/news/october-20…
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🔍 Nearly half (48%) of patients with high-risk #Melanoma developed chronic immune-related adverse events after adjuvant anti–PD-1 therapy.
➡️ At a median follow-up of 67 months, 34% had ongoing toxicity
▪️Douglas B. Johnson, MD | @JAMANetworkOpen
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🤝@ASCO and @WHO have signed a collaboration agreement that is focused on:
1⃣ building professional competencies in #CancerCare
2⃣ improving access to #clinicaltrials
3⃣ strengthening quality, accessibility & accountability in #cancer care
Learn more ➡️ ascopost.com/news/october-20…
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🖥️ #ASCOAI: This week in #AI and #CancerCare:
🔹Predicting #PancreaticCancer risk years before diagnosis
🔹AI-assisted contouring benefits trainees
🔹Predicting ICI-related pneumonitis risk in #LungCancer
🎥Watch the latest news brief: ascoai.org/videos/weekly-bri…
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🔬Hereditary #CancerRisk isn't limited to younger patients.
Germline pathogenic variants were identified in 18.4% of early-onset, 15.6% of average-onset & 12.3% of late-onset cases, supporting broader genetic testing.
🔹Drs. Diaz & Stadler | @CD_AACR
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💆How can #Oncology teams better integrate acupuncture and massage for cancer pain?
Kelly M. McConnell, PhD, and Jun J. Mao, MD, MSCE, outline how the IMAGINE project addresses training, awareness, and implementation barriers.
Explore the findings ➡️ ascopost.com/news/october-20…
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🖥️ #ASCOAI: A transformer-based #AI model developed at @MayoClinic predicted #PancreaticCancer risk up to 5 years before diagnosis, achieving an AUROC of 0.853.
The model uses routine lab results and diagnostic histories to identify high-risk patients
🔗 ascoai.org/articles/2026/10/…
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🩻 Automated breast ultrasound had similar #BreastCancer detection rates to handheld ultrasound, with fewer false-positive initial assessments
➡️Findings support ABUS as alternative for screening women with dense breasts
▪️Brian Sprague, PhD | @JACRJournal
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➕Adding sitagliptin to antithymocyte globulin–based prophylaxis reduced acute #GVHD after alternative donor transplantation.
➡️ Phase III trial found no significant improvement in 2-year overall or relapse-free survival
▪️Yang Xu, MD | @JCO_ASCO
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🏃A 12-week remote exercise program improved quality of life in 75.8% of patients receiving #Immunotherapy vs 6.3% with usual care.
➡️ Findings from a phase II trial highlight the benefits of exercise in #CancerCare
🔹@PauloBergerot | #ASCOQLTY26
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🧬Proactive outreach and navigation may improve hereditary #CancerRisk assessment
In the FaCT trial, 90% of relatives receiving facilitated #BRCA 1/2 testing completed by 18 months vs 62% with standard care.
🔹Roni Nitecki Wilke, MD, MPH | @JCO_ASCO
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💰Financial toxicity remains a major challenge in #CancerCare.
The CREDIT trial found that navigation support alone may not be enough for patients at greatest financial risk, highlighting a need for tailored interventions.
▪️@ShankaranVeena | #ASCOQLTY26
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🔬#ASCOAI: Can #AI help detect #SkinCancer before it becomes clinically visible?
The SUBSCAN approach combines real-time AI image recognition with noninvasive LC-OCT to identify subclinical basal cell carcinomas.
❗Researchers caution about overdiagnosis
ascoai.org/articles/2026/10/…
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🫁Higher abdominal fat was associated with increased #LungCancer risk in a study of 1,170 high-risk individuals.
Findings challenge the “obesity paradox” and suggest central adiposity may contribute to lung carcinogenesis
🔸Dr. Sai Yendamuri | @JTOonline
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🫂#ASCOAI: The proposed PRECISION-AI framework from @SylvesterCancer outlines a path for integrating #AI into cancer survivorship #supportivecare, from symptom monitoring to psychosocial assistance.
Learn more ➡️ ascoai.org/articles/2026/10/…
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