Transcription and RNA processing; postdoc in @STOPlabPI group @UAM_IBMiB
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For decades, pre-mRNA 3′ cleavage and transcription termination were seen as tightly coupled. But they can shift in opposite directions.
Building on our recent EMBO Journal paper, we gathered evidence from across the field in @TrendsGenetics 👇
doi.org/10.1016/j.tig.2026.0…
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Agata Stepien retweeted
New paper in @embojournal!
@AgataKStepien, @DPulimamidi & @STOPlabPI reveal that RNA cleavage and transcription termination shift in opposite directions in colorectal cancer cells. Their proximity is linked to gene expression and cancer cell vulnerability! link.springer.com/article/10…
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Agata Stepien retweeted
Primary and metastatic colorectal tumor cells share a common origin, but do they share the same vulnerabilities?
Surprisingly, primary cells depend far more on #PCF11 and #CPSF73, two pre-mRNA processing/termination factors.
Our latest study explores why: tinyurl.com/3pkeuctp
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Two steps in gene expression that should move together…don’t. In our new paper we show that pre-mRNA cleavage and RNA polymerase II (RNAPII) termination shift in opposite directions – with a surprising link to gene expression and cancer cell vulnerability tinyurl.com/3pkeuctp
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5. Many thanks to @STOPlabPI, @DPulimamidi, @real_lab_duck, Maxime Lalonde, @kopczynska_m, Klaudia Ostatek, Mariia Kapeliukha, Shazia Irshad, Hiroshi Kimura, @michal_gdula, and Stephan Hamperl for a great collaboration on this project. tinyurl.com/3pkeuctp
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Studying gene ends is becoming even more fascinating❗️ Curious why❓ Read our News & Views "Transcriptional readthrough progresses from incidental byproduct to therapeutic opportunity" inspired by the recent publication from Podszywałow-Bartnicka and Karla Neugebauer @NatureSMB
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Did you know that changes in pre-mRNA 3' cleavage and RNAPII termination can go in different directions? Even more, the spacing between these two events is linked to the gene expression level❗️Check out our latest pre-print to learn more tiny.cc/330w001 1/6
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4. Shortening of the distance between pre-mRNA cleavage and RNAPII terminal pausing is associated with higher gene expression❗️
Shortened spacing = higher expression BUT also higher addiction to PCF11 and CPSF73. 5/6
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5. Many thanks to @STOPlabPI , @DPulimamidi, @real_lab_duck, Maxime Lalonde, @kopczynska_m , Shazia Irshad, Hiroshi Kimura, @michal_gdula , and Stephan Hamperl for a great collaboration on this project. 6/6
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Agata Stepien retweeted
HIRING! STOP lab is looking for a Research Assistant (Technician) with experience in protein expression and purification @czt_uam @UAM_IBMiB @UAM_Poznan. Job & project description and how to apply here: euraxess.ec.europa.eu/jobs/3…
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Agata Stepien retweeted
🚀 We’re hiring a #Postdoc!
Join our group in Poznan, Poland to study meiotic crossover recombination in plants🌱 Highly motivated & enthusiastic candidates are welcome!
📅 Deadline: Nov 1, 2025
🔗 ibmib.web.amu.edu.pl/wp-cont…
#PlantScience #Meiosis #PostdocJobs
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A beautiful story about the role of SETD2 in RNAPII transcription 💗
🚨New preprint from our labs (STOP lab & Nojima lab @pol2rna)! @kopczynska_m and Chihiro Nakayama have been digging into how chromatin remodeller SETD2 controls the start and end of transcription 👇 (1/5) biorxiv.org/cgi/content/shor…
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