Aging Science News
@AgingBiology

Latest news in the biology and genetics of aging, covering longevity science, rejuvenation technologies and life-extension research. Tweets by @jpsenescence

senescence.info/
Joined November 2013
130 Photos and videos
New description of the Human Ageing Genomic Resources (HAGR) Since its inception 20 years ago, HAGR has become the leading online platform in ageing research. A brief thread on HAGR's databases 🧵 academic.oup.com/nar/article…

Human Ageing Genomic Resources: updates on key databases in ageing research

Abstract. Ageing is a complex and multifactorial process. For two decades, the Human Ageing Genomic Resources (HAGR) have aided researchers in the study of

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Tree Shrew as an Emerging Model for Aging Research: Characterization of Senescence and Therapeutic Interventions onlinelibrary.wiley.com/doi/…

Tree Shrew as an Emerging Model for Aging Research: Characterization of Senescence and Therapeutic...

Compared with mouse cells, tree shrew fibroblasts more faithfully recapitulate the hallmarks of human cellular senescence. In vivo, aged tree shrews exhibit transcriptomic signatures of aging across...

onlinelibrary.wiley.com
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In Silico Single-Cell Transcriptomic Analysis Reveals Senescence-Associated Programs’ Progress Along the Normal–Adenoma–Carcinoma Sequence in Colorectal Cancer mdpi.com/1422-0067/27/21/979…

In Silico Single-Cell Transcriptomic Analysis Reveals Senescence-Associated Programs’ Progress...

Colorectal cancer (CRC) develops through a multistep progression from normal colonic mucosa to adenoma and ultimately carcinoma. However, the cell-type-specific senescence-associated states during...

mdpi.com
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Comparative Proteomic Quantification Reveals Novel Longevity Regulators analyticalsciencejournals.on…

Comparative Proteomic Quantification Reveals Novel Longevity Regulators

Proteomics is a powerful tool for profiling the protein landscape underlying cellular and physiological processes. Advances in mass spectrometry-based methods, such as tandem mass tags (TMT) isobar...

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TOP2A Maintains Heterochromatin Stability by Sustaining LMNB1 Expression to Counteract Senescence onlinelibrary.wiley.com/doi/…

TOP2A Maintains Heterochromatin Stability by Sustaining LMNB1 Expression to Counteract Senescence

Depletion of TOP2A accelerates MSC senescence and disrupts heterochromatin integrity. TOP2A directly regulates LMNB1 expression to maintain MSC nuclear integrity and epigenomic stability. Overexpre...

onlinelibrary.wiley.com
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Repurposing Regulatory Rodent Toxicology Safety Archives to Identify Candidate Hormetic Longevity Agents Highlights Emergent Mitochondrial Mechanisms onlinelibrary.wiley.com/doi/…

Repurposing Regulatory Rodent Toxicology Safety Archives to Identify Candidate Hormetic Longevity...

Mining regulatory rodent toxicology archives for pesticides uncovers substances that paradoxically enhance survival, revealing an underused resource for longevity discovery. Many candidates act via...

onlinelibrary.wiley.com
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Lithium-Doped Hydroxyapatite Nanowires Rejuvenate Senescent Macrophages Via the Lysosome-Dependent Ferroptosis Axis to Promote Aged Bone Regeneration advanced.onlinelibrary.wiley…

Lithium‐Doped Hydroxyapatite Nanowires Rejuvenate Senescent Macrophages Via the Lysosome‐Dependent...

Li-nHAP+GelMA promotes mandibular bone regeneration in aged mice by remodeling the senescent immune microenvironment. Local delivery of Li-nHAP restores lysosomal homeostasis in senescent macrophag...

advanced.onlinelibrary.wiley.com
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Fatty acid desaturation controls cellular fate decisions between senescence and ferroptosis cell.com/cell/fulltext/S0092…

Fatty acid desaturation controls cellular fate decisions between senescence and ferroptosis

Polyunsaturated fatty acid metabolism shapes cell fate decisions: loss of DGLA favors senescence, whereas DGLA repletion triggers ferroptosis.

cell.com
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Integrative prioritization of human longevity genes and their miRNA regulators link.springer.com/article/10…

Integrative prioritization of human longevity genes and their miRNA regulators

Network Modeling Analysis in Health Informatics and Bioinformatics - Human longevity is a complex phenotype influenced by numerous genetic variants whose reported associations vary across studies...

link.springer.com
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Dysfunction of lipid metabolism and lysosomal capacity: at the core of microglial aging? frontiersin.org/journals/agi…

Frontiers | Dysfunction of lipid metabolism and lysosomal capacity: at the core of microglial aging?

As primary immune cells of the central nervous system (CNS), microglia maintain immune surveillance, inflammation regulation, cell interactions and debris cl...

frontiersin.org
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Establishing a Biophotonic Signature of Brain Ageing onlinelibrary.wiley.com/doi/…

Establishing a Biophotonic Signature of Brain Ageing

If we excite autofluorescence from brains with a 488 nm laser, young brain autofluorescence shows blue-shifted spectra; aged brain autofluorescence shows red-shifted spectra. This spectral shift is...

onlinelibrary.wiley.com
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The Lysosomal Clock: Are We Only as Old as Our Lysosomes? onlinelibrary.wiley.com/doi/…

The Lysosomal Clock: Are We Only as Old as Our Lysosomes?

The lysosomal clock of aging. Aging is associated with lysosomal accumulation of glycerophosphodiesters (GPDs) and cystine, alongside remodeling of bis(monoacylglycero)phosphate (BMP). This conserv...

onlinelibrary.wiley.com
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A Novel Peptide Targeting the USP25–SIRT1 Interaction Activates SIRT1 to Suppress Cell Senescence onlinelibrary.wiley.com/doi/…

A Novel Peptide Targeting the USP25–SIRT1 Interaction Activates SIRT1 to Suppress Cell Senescence

USP25-mediated K63-linked deubiquitination of SIRT1 at K506 and K513 suppresses its activity to promote senescence. These findings unveil a novel aging regulatory axis and identify a peptide target...

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Senomorphic miR-3155b suppresses the senescence-associated secretory phenotype in therapy-induced senescence frontiersin.org/journals/cel…

Frontiers | Senomorphic miR-3155b suppresses the senescence-associated secretory phenotype in...

Senomorphic microRNAs (miRNAs) are a class of small regulatory RNAs that selectively suppress the senescence-associated secretory phenotype (SASP) without el...

frontiersin.org
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Chaperone-mediated autophagy curbs senescence nature.com/articles/s43587-0…

Chaperone-mediated autophagy curbs senescence

Nature Aging - Sereda and colleagues show that chaperone-mediated autophagy declines with aging, which leads to enhanced senescent cell burden that is driven, in part, by failed macrophage-mediated...

nature.com
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Shared cancer resistance but divergent immune responses in two long-lived African mole-rat species: the naked mole-rat and the Damaraland mole-rat link.springer.com/article/10…

Shared cancer resistance but divergent immune responses in two long-lived African mole-rat species:...

GeroScience - Several exceptionally long-lived mammals show natural resistance to cancer. The longest-lived rodent, the naked mole-rat (NMR; Heterocephalus glaber) is renowned for its remarkable...

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Worms live longer in cool conditions thanks to a muscle-derived molecule nature.com/articles/d41586-0…

Worms live longer in cool conditions thanks to a muscle-derived molecule

Nature - In nematodes, a metabolite induced by the cold links low temperatures to a body-wide signal that promotes longevity. This signalling system is also seen in human cells.

nature.com
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Comparative Genomics Reveals Signatures of Distinct Metabolic Strategies and Gene Loss Associated With Hydra Immortality academic.oup.com/gbe/article…

Comparative Genomics Reveals Signatures of Distinct Metabolic Strategies and Gene Loss Associated...

Abstract. Hydra is a freshwater cnidarian genus that provides a unique comparative model for aging research, contrasting the immortal Hydra vulgaris with t

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Cellular senescence is associated with age-related loss of liver zonation and hepatocyte function biorxiv.org/content/10.64898…
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Ginsenoside Rg1 promotes mitophagy and delays aging through the DAF-16 in Caenorhabditis elegans link.springer.com/article/10…

Ginsenoside Rg1 promotes mitophagy and delays aging through the DAF-16 in Caenorhabditis elegans

Biogerontology - Ginsenoside Rg1, the main active component of Panax ginseng, has been shown to improve mitochondrial function and delay cell aging by regulating chaperone-mediated mitophagy....

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Cysteine reduction rather than methionine restriction promotes immunometabolic fitness to confer survival benefit in aging biorxiv.org/content/10.64898…

Cysteine reduction rather than methionine restriction promotes immunometabolic fitness to confer...

Elevated sulfur-containing amino acids (SAA; methionine and cystine) are linked to human mortality. While methionine restriction (MR) extends lifespan in animals, it is often ignored that traditional...

biorxiv.org
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