allen institute@AllenInstitute

accelerating science for a healthier world

 Seattle, WA
alleninstitute.org
Joined October 2010
6,604 Photos and videos
What if the next breakthrough for human health, climate resilience, or clean energy isn’t waiting to be found in nature, but is waiting to be designed? Today, we’re launching AI BioDesign, a bold endeavor to explore the uncharted design space of life.
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Sue Kaech, EVP and Director of Immunology at the Allen Institute, has been elected to the National Academy of Medicine for achievements in immunology. Her research explains how immune memory forms and how cancer can disable it. Congratulations, @Tcellogic! bit.ly/4k4TAPN
A person smiling in a professional setting, with text stating "Sue Kaech elected to the National Academy of Medicine for achievements in immunology.

ALT A person smiling in a professional setting, with text stating "Sue Kaech elected to the National Academy of Medicine for achievements in immunology.

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AI neurons run on simple math. Real neurons are far weirder. A new open dataset fitted 1,000+ PyTorch-ready neuron models to real mouse and human cells. Does brain-like diversity make AI better? It's still an open question, but now it's testable. bit.ly/3WfGAwR
Illustration showing a connection between neuroscience and machine learning, featuring diagrams of neurons and circuits. Text reads: "A new bridge between neuroscience and machine learning. Artificial neurons run on simple math, but real brain cells are far richer. Can brain-like diversity make AI better?

ALT Illustration showing a connection between neuroscience and machine learning, featuring diagrams of neurons and circuits. Text reads: "A new bridge between neuroscience and machine learning. Artificial neurons run on simple math, but real brain cells are far richer. Can brain-like diversity make AI better?

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Brain rhythms behind memory weaken in Alzheimer’s, but why? A new study from @GladstoneInst and the Allen Institute shows cells fire in waves, like passing a baton. In Alzheimer’s the handoff breaks. Boosting Nav1.1 restored the beat and improved memory.
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Read more at bit.ly/4yx1bu5

In Alzheimer’s Disease, the Brain’s Pacemaker Cells Lose Their Beat | Gladstone Institutes

Research in mice reveals how critical brain cells misfire in Alzheimer’s and identifies a targeted strategy to restore healthy brain rhythms.

gladstone.org
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Our #CellLineOfTheWeek is TRF2! 🧫✨ This cell line and plasmid illuminates telomeres - the protective tips of chromosomes. Our stem cell lines and plasmids are openly available to power the next breakthrough. 📦 @Coriell_Science and @Addgene
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#CellBio community, this one is for you! Applications are open for the #LakeConference on Modeling Life from Cells to Tissues! 📆 Mar. 21-25, 2027 📍 Lake Thun, Switzerland 🔬 All career stages welcomed Apply to attend by 12/10: bit.ly/4ANhchR
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The Allen Institute team was one of 17 nonprofit, academic, and social enterprise teams selected from more than 3,000 applicants in 30 countries, recognized for leadership in using AI to accelerate science. blog.google/company-news/out…

17 organizations using AI to accelerate scientific breakthroughs

These groups are receiving $36 million through the Google.org Impact Challenge: AI for Science.

blog.google
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Congratulations to our Allenites for winning a "Google Impact Challenge: AI for Science” award for their project, Generative AI to Design Precision Genetic Tools from Cell Atlases!
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How can we understand the neural circuits that shape behavior? Join us at #SfN26 for a Neural Dynamics satellite workshop to explore open data and tools for neuropixels recordings, neuron reconstructions, and multimodal analysis. register/ bit.ly/3Uu0p31
The image is a promotional poster for a "neural dynamics/" satellite workshop happening on November 14 from 7–10 am, associated with "sfn26." The poster features a microscopic image of neural tissue as the background, with text in bright colors. A "register/" button with an orange arrow icon is included at the bottom.

ALT The image is a promotional poster for a "neural dynamics/" satellite workshop happening on November 14 from 7–10 am, associated with "sfn26." The poster features a microscopic image of neural tissue as the background, with text in bright colors. A "register/" button with an orange arrow icon is included at the bottom.

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amber waves of brain/ When we think of waves, our minds might travel to the tranquility of ocean beaches. But brains also pulse with wave cycles. This video illustrates the neural activity of a mouse brain. Learn more in this #SciShots: bit.ly/47lkyLv
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We’re excited to announce the 2nd International Workshop on Neuro for AI & AI for Neuro, taking place Feb 22–23, 2027, in Montreal 🇨🇦 alongside @RealAAAI 2027! 🎉 📢 Call for Papers is now open! For more info and submission details: neuroai-multimodal-workshop.… #NeuroAI #AAAI2027
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Brain donation is not as simple as becoming an organ donor. From enrollment to collection, it’s a delicate and complex process. But the impact can be profound with some brains still being studied 30+ years after donation. alleninstitute.org/news/so-y…

So you want to donate your brain to science

Monte Strohl donated his brain to research after his death, hoping to fuel science and help others with neurodegenerative conditions.

alleninstitute.org
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"An exciting opportunity to make fundamental discoveries." Applications for the Shanahan Foundation Fellowship at the Interface of Data and Neuroscience are now open! Experience in #neuroscience is not needed. Apply by Dec. 1: bit.ly/4h762LH
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Applications are open for the Studio D3 Fellowship at the Allen Institute! This 3-year fellowship empowers recent PhDs with quantitative backgrounds to apply computational and theoretical approaches to biology's most complex challenges. Apply by 12/1: bit.ly/4rgbTmD
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Great science doesn't happen alone. More than 160 early-career researchers gathered at the first Stem Cell & Developmental Biology Early Career Symposium to share research, build community, and learn skills that matter beyond the lab. bit.ly/3TyktRx
A panel of four individuals seated on stage engaging in a discussion at the "stem cell and developmental biology symposium." The screen behind them displays text emphasizing the importance of activities outside the lab.

ALT A panel of four individuals seated on stage engaging in a discussion at the "stem cell and developmental biology symposium." The screen behind them displays text emphasizing the importance of activities outside the lab.
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Neurons come in many different morphologies or shapes. Check out just some of the diversity of just inhibitory neurons in this beautiful video by our #ElectronMicroscopy team.
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Our #CellLineOfTheWeek is a 3-for-1 and fluoresces fibrillarin, nucleophosmin, and dCas9-KRAB! 🦀🧫 Our cell lines & plasmids are openly available to accelerate scientific discovery: allencell.org/cell-catalog.h… 📦 Distributed by @Coriell_Science and @Addgene
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MapMyCells is one of our most popular #OpenScience tools and for good reason! Scientists anywhere can discover what cell types their transcriptomics and spatial data corresponds with by comparing their data to massive, high-quality reference datasets. 🔗 bit.ly/4uZDDgm
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Scientists at Seattle Hub for Synthetic Biology just built the largest cellular family tree ever for a mammal, tracing how a single egg divided into 1.28 million cells. bit.ly/4zqcRjh
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Using tech called DNA Typewriter, which writes genetic stamps into a cell’s genome every time it divides, the team was able to read 1.58 million cell nuclei to reconstruct the whole lineage. science.org/doi/10.1126/scie…

A DNA Typewriter records the cell lineage history of a mouse, from zygote to late organogenesis

Mammalian biology unfolds over time, within tissues and organs opaque to our eyes and instruments. We applied DNA Typewriter, a sequential molecular recorder, to record the cell lineage of a mouse...

science.org
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A map of normal development gives researchers a baseline for understanding birth defects, cancer, and more, revealing when and where cells go off course. The full tree is public via an interactive browser called NextCell: nextcell.seattlehub.org/

NextCell — every cell in one mouse embryo, traced back to the zygote

An interactive browser for the lineage tree of 1,281,141 cells from one mouse embryo, recorded with DNA Typewriter and dated from the zygote to E13.5.

nextcell.seattlehub.org
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