Andrey@Aparhit
Joined April 2014
A genetically encoded tool to increase cellular NADH/NAD+ ratio in living cells biorxiv.org/content/10.1101/…

A genetically encoded tool to increase cellular NADH/NAD+ ratio in living cells

Impaired reduction/oxidation (redox) metabolism is a key contributor to the etiology of many diseases, including primary mitochondrial disorders, cancer, neurodegeneration, and aging. However,...

biorxiv.org
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Pre-print is here: biorxiv.org/content/10.1101/…

A genetically encoded tool to increase cellular NADH/NAD+ ratio in living cells

Impaired reduction/oxidation (redox) metabolism is a key contributor to the etiology of many diseases, including primary mitochondrial disorders, cancer, neurodegeneration, and aging. However,...

biorxiv.org
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Our story is finally out in PlosGenetics journals.plos.org/plosgeneti… We identified novel RB1-specific synthetic lethal interactions that are conservative between flies and humans. We also created a novel Drosophila cancer model. I would like to thank everyone for their help!

Cross-species identification of PIP5K1-, splicing- and ubiquitin-related pathways as potential...

Author summary RB1 is a tumor suppressor gene that is inactivated in a significant proportion of all cancer cases. A therapeutic approach that specifically targets defects associated with this tumor...

journals.plos.org
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Our story is finally out in eLife. elifesciences.org/articles/5… We demonstrate the connection between aging, mitochondria dysfunction, and tyrosine-derived neurotransmitter production. Suppression of tyrosine degradation extends lifespan and promotes production of neurotransmitters.

Downregulation of the tyrosine degradation pathway extends Drosophila lifespan

The tyrosine degradation pathway reprogramming connects mitochondrial dysfunction, aging, and production of tyrosine-derived neuromediators that can be targeted with an FDA-approved drug, Tigecycline.

elifesciences.org
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The tyrosine degradation pathway can be targeted with an FDA-approved drug, Nitisinone/Orfadin/NTBC that could be interesting to test in mammals. I would like to thank everyone for their help and support!
Pre-proof version of our review: Targeting metabolic pathways for extension of lifespan and healthspan ... sciencedirect.com/science/ar…
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'First in Fly' by Dr. Stephanie Mohr named one of the ten best science books of 2018 by Smithsonian magazine! Congratulations @smohrfly! (bit.ly/2G3kPcg)

The Ten Best Science Books of 2018

These titles explore the wide-ranging implications of new discoveries and experiments, while grounding them in historical context

smithsonianmag.com
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