Effective healing of
#diabetic wounds involves myofibroblasts, which contract to aid in wound closure.
Here, Katherine Gallagher
@BTBKGMD & team @UMichMedSchool show fibroblasts from diabetic wounds have increased Setdb2, which represses the fibroblast-to-myofibroblast transition:
insight.jci.org/articles/vie…
The figure shows tofacitinib, an FDA-approved small molecule inhibitor of Jak 1,3, improved wound healing in mice.