Vivien Béziat@BeziatV

Primary immunodeficiencies, hyper-IgE syndrome, papillomaviruses. Still a NK cell aficionados.

 Paris, France
Joined May 2019
24 Photos and videos
Out in @CellCellPress today! We describe the first humans with inherited, complete FLT3L deficiency. Despite a lack of most dendritic cells, they reached adulthood. See the thread below for the main highlights of our paper. cell.com/cell/fulltext/S0092…

FLT3L governs the development of partially overlapping hematopoietic lineages in humans and mice

Adult humans with inherited, complete FLT3L deficiency enable valuable insights into the role of the hematopoietic growth factor FLT3L in human hematopoiesis, revealing that FLT3L deficiencies impair...

cell.com
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🧬 New in @CellGenomics 🧵 1/ With @CasanovaLab, we propose a rethinking of monogenic disorders of immunity: 👉 common variants can matter — a lot.
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I meant @casanova_lab ! Wrong tag :-).
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6/ This argues for stronger dialogue in clinical immunology (and other medical fields) between patient-based and population-based genetics —biology and medicine sit at their intersection.
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7/ 📖 Monogenic disorders of immunity: Common variants are not so rare Cell Genomics (2025) 🔗 cell.com/cell-genomics/fullt… #Immunology #HumanGenetics #InbornErrorsOfImmunity #IEI #Genomics #PopulationGenetics #PrecisionMedicine

Monogenic disorders of immunity: Common variants are not so rare

While monogenic disorders of immunity typically involve rare alleles, some arise from alleles common in specific populations. Examples include IFNAR1/2 null alleles in the Arctic/Pacific and PTCRA...

cell.com
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Vivien Béziat retweeted
Casanova Lab@casanova_lab
5 Dec 2025
1/ A year ago, a 71-year-old Louisiana man died from H5N1, marking the first avian flu death in the US. Now we report in @JExpMed that the cause of his death is rogue autoantibodies neutralizing type I IFN (AutoAb-IFN). doi.org/10.1084/jem.20251962
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In a new research letter, Materna, @BeziatV et al. identified six individuals with homozygous truncating variants in the pre-TCRα intracellular tail, revealing hypomorphic and neutral alleles. hubs.la/Q03V1P890 @casanova_lab @ESIDsociety
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Materna, @BeziatV et al. @institutimagine report children with complete TCRα deficiency, a lack of αβ T cells, & a severe condition. Previously characterized TCRα deficiency, which wasn't as severe as expected, was partial, as opposed to complete hubs.la/Q03qMb0m0
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🚨 Our first paper in @jhumimmunity just came out! We describe two forms of TCR⍺ deficiency: a complete and a partial form. 👉 doi.org/10.70962/jhi.2025001…
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Please consider submitting your work to @jhumimmunity, the novel journal of the “Inborn Error of Immunity” community. It is published by the nonprofit @RockUPress
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Thank you to all the fantastic collaborators involved in this story. @casanova_lab, @BustamanteJaci1 @ParvanehNima @ManaMomenilandi, and all not on X, in particular Marie Materna, Simin Seyedpour, Tom Le Voyer, Niloufar Yazdanpanah, Mohammad Shahrooei and Nima Rezaie
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Vivien Béziat retweeted
BogunovicLab@BogunovicLab
1 Jan 2025
What Happens When Some Cells Are More Dad Than Mom (and Vice Versa)? Latest from us. Published today. News here cuimc.columbia.edu/news/what… article here: nature.com/articles/s41586-0… @stewart_ojay @BogunovicLab and a huge international team thank you 🙏🏼 @KidsAtColumbia @SinaiImmunol

What Happens When Some Cells Are More Dad Than Mom (and Vice Versa)?

A new study shows that some of our cells favor genes of one parent or the other and can explain a longstanding mystery of why some people with disease-causing genes experience no symptoms.

cuimc.columbia.edu
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