New issue of Blood out now featuring A TAG team for achieving deep remissions in BPDCN, MEIS1 guardian USP22 fuels transcription in KMT2Ar leukemia, Securing HMO coverage for HSCT, and more. Explore here: ashpublications.org/blood/is…
New episode of the Blood Podcast out now discussing new drug combinations for #BPDCN and reduced intestinal dysbiosis after #HSCT. Dr. Laurie Sehn interviews Drs. Andrew Lane of @DanaFarber and Pooja Khandelwal of @CincyChildrens on their latest research:
bloodpodcast.transistor.fm/e…
Immediate implant reconstruction after mastectomy yielded 54% lower DVT and 33% lower hematoma rates. Procedural complexity alone does not determine clotting and bleeding risk after breast cancer surgery; patient selection matters. Read in Blood VTH: ow.ly/ZubZ50ZZ7zc
An Hb and heme-binding ApoHb-Hp complex protects the heart and kidneys from injury caused by chronic hemolysis. Female mice show partial natural resilience to hemolysis, and both sexes benefit from ApoHb-Hp treatment. Read in Blood RCI: ow.ly/GmTN5101LGT
There is an unmet need to overcome resistance to venetoclax in #AML, particularly in the context of TP53 mutations. Pitavastatin enhances venetoclax cytotoxicity in AML cell lines and primary samples, including those with common mechanisms of resistance. ow.ly/WgXW50ZZ37A
The SickleFit virtual exercise intervention is feasible and highly enjoyable for adults aged ≥40 years with #SCD. Participants demonstrated improvements in physical performance, with 65% showing increased endurance on 6-minute walk. Read in Blood RCI: ow.ly/1otc5101rww
New issue of Blood Advances out now! Featuring A next-generation FVIIIa mimetic in the making, A comprehensive review of T-cell lymphoma following CAR T-cell immunotherapy, and more. Explore here: ashpublications.org/bloodadv…
In comparison of DEC vs AZA, there was no difference in OS or LFS for patients with #MDS. There were no major differences in transfusion dependence or QoL metrics for patients treated with DEC vs AZA. Read in Blood Neoplasia: ow.ly/pes050ZZ33A
Plasma serotonin is cleared even after SERT inhibition, indicating compensatory, SERT-independent pathway(s) can maintain serotonin balance. Read the full article in Blood VTH: ow.ly/kJJ750ZZ7o6
This is, to our knowledge, the first large-scale quantitative characterization of TET2 VAF as a continuous prognostic variable in #CMML. Read the full multicenter study in Blood Neoplasia: ow.ly/hcWF50ZZ7p8
asxl1 and IDH2R172K comutation epigenetically silences tet2 and activates the MAPK and AP-1 pathways in leukemia. Targeting DNA methylation, ROS, MAPK, and AP-1 mitigates leukemogenesis associated with asxl1 and IDH2R172K comutations in zebrafish. ow.ly/fI3K50ZZ2bW