Brain: A Journal of Neurology. Publishing leading studies in neurological science since 1878.
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We are pleased to announce that registration for the 2027 Brain Conference is now OPEN!
The conference will be held on 12 March, 2027.
Visit the website to view our speakers, register to attend and see information on abstract submissions: conference.guarantorsofbrain…
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Lastra Osua et al. review the role of TMEM106B in neurodegenerative diseases. They describe how genetic variants alter TMEM106B expression & processing, lysosomal function, and synaptic biology, and discuss how these effects converge to shape disease risk. shorturl.at/Dpw5K
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Using mouse models validated against human preterm tissue, Sanidas et al. show that hypoxia and maternal immune activation disrupt cerebellar development in different ways, leading to distinct motor and social difficulties. shorturl.at/QO7dr
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Johari et al. identify novel TUBA4A variants that cause primary myopathies, often without CNS involvement, expanding the known phenotypic spectrum and establishing myo-tubulinopathies as a new disease group. academic.oup.com/brain/artic…
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White matter lesions disrupt cholinergic transmission to impact cognition in Parkinson’s disease
New scientific commentary by Patrick Murphy, Angeliki Zarkali & Rimona Weil shorturl.at/gtGoe
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Cossette-Roberge et al. review evidence that some brain regions become thicker, rather than thinner, in temporal lobe epilepsy, and conclude that this cortical hypertrophy may reflect seizure-related changes or compensation within brain networks. shorturl.at/p3CKK
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Maletic et al. used patient-derived mosaic cortical organoids to model focal cortical dysplasia caused by two-hit DEPDC5 mutations. They show that biallelic DEPDC5 loss disrupts corticogenesis and increases neuronal excitability. shorturl.at/eIK3x
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Woo et al. analysed >7000 adults with type 2 diabetes initiating GLP-1 receptor agonists. Higher genetically proxied GLP1R expression was associated with a lower risk of Parkinson’s disease and related disorders. shorturl.at/ISqAp
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Tsujikawa et al. show that excess filamin-A triggers cytoskeletal stress and widespread transcriptional dysregulation, leading to progressive dopaminergic dysfunction in progressive supranuclear palsy. shorturl.at/JLF2T
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Brain retweeted
Don’t miss your chance to enter the @Brain1878 annual essay competition!
Everyone is welcome to submit, no matter your background and essays can cover any aspect of the human condition.
Enter before 31st October for your chance to win!
Submit Now : oxford.ly/481VOrO
ALT Brain Essay Competition. Submit before 31st October 2026. Learn more. BRAIN. Oxford University Press.
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In a randomized, double-blind, sham-controlled trial, Wei et al. examine the efficacy of neuronavigated dual-target repetitive TMS over the cerebellum and right DLPFC for the treatment of negative symptoms in early-stage psychosis. shorturl.at/LgTXn
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Siew et al. identify berbamine hydrochloride as a brain-penetrant inhibitor of galectin-3, a protein that drives neuroinflammation. They show that this compound reduces microglial activation and improves symptoms in a Huntington’s disease mouse model. shorturl.at/wmh2m
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Dutta et al. show that extracellular vesicle-associated α-synuclein differs in conformation and distribution across Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy. shorturl.at/B5xC4
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Averdunk et al. identify biallelic PIKFYVE variants as a cause of hypomyelinating leukodystrophy and developmental problems. The variants impair production of PI(3,5)P2, a membrane lipid that regulates endolysosomal function. shorturl.at/wJCSH
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Suppa et al. explore why rigidity in Parkinson’s disease remains poorly understood, highlighting inconsistencies in its definition and interpretation. They propose new approaches to better characterize its underlying mechanisms and clinical impact. shorturl.at/Dnbd2
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Artusi et al. review clinical trials in Parkinson’s disease and related disorders to examine whether biological markers of drug activity predict clinical benefit. shorturl.at/tMoxB
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In an analysis of almost one million genomes, Rahman et al. find that myotonic dystrophy type 1 is more common than previously recognised, with pathogenic DMPK repeat expansions present in about 1 in 1,500 people. shorturl.at/it6Ka
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De Lorenzo et al. show that, in people with ALS, white matter hyperintensity burden on MRI is associated with more advanced disease, more severe lower motor neuron dysfunction and cognitive deficits, and shorter survival. shorturl.at/FuEt8
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Lyndon proposes that functional neurological disorder reflects disordered precision control in predictive coding. Arousal may transiently over-amplify confidence in maladaptive predictions so that they override intact sensory feedback. shorturl.at/0NlSQ
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Régis et al. report the first prospective phase 2 trial of staged bilateral radiosurgery for drug-resistant essential tremor, demonstrating tremor reduction with no significant worsening of cognition, speech, gait or balance. shorturl.at/FOm5W
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When disease illuminates physiology: mapping hidden fluid pathways in the human brain
New scientific commentary by Jeremy Ford, Marc Bouffard, Karen Buch & Jeffrey Iliff shorturl.at/tMeAK
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