Editors of Current Opinion & Current Research in Structural Biology. Opinions are our own. All aspects of molecular structure & dynamics of macromolecules
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We are so grateful to our structural biology community for helping us grow Current Research in Structural Biology for the past 2 years, shaping it into a great place to publish, raise visibility of all your structural biology research! bit.ly/3LVqSgJ
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Deep learning is reshaping how we predict protein disorder. This COSB review covers cutting-edge methods and how community efforts are advancing the field.
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#proteinDisorder #deeplearning #COSB
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Genotype to Phenotype: Bridging Biochemistry & Genetics. How do variants lead to disease? This COSB review blends genetics and biochemistry to decode the path from genotype to complex phenotype.
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#genomics #biochemistry #COSB
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From mRNA vaccines to Paxlovid: the Protein Data Bank was key to COVID-19 drug and vaccine design. Read how structural data saved lives.
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#COVID19 #PDB #structuralbiology
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How do disordered regions evolve to fine-tune protein interactions? This COSB review applies an evolutionary lens to the folding-upon-binding process.
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Protein language models (pLMs) are redefining structure prediction, capturing the “grammar of life” directly from sequences and often outperforming MSA-based methods with fewer resources.
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Residue Interaction Networks reveal the logic behind protein structure and evolution. This review showcases how graph theory guide ms protein engineering.
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#proteinengineering #bioinformatics
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Missense mutations in intrinsically disordered regions can reshape protein structural ensembles—and their function. Learn how a single point mutation can shift the dynamic landscape of disordered proteins.
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Where did proteins come from? This COSB review explores how short peptide “building blocks,” traced by bottom-up chemistry & protein space mining, illuminate the ancient origins and evolution of modern proteins.
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#proteinevolution #structuralbiology
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Guest editors Yana Bromberg and Benjamin Schuler introduce article collection on Folding and Binding (2025), discussing Protein folding and binding with a little help from AI: sciencedirect.com/science/ar…
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Molecular simulations are unlocking the physics of biomolecular condensates. Explore how coarse-grained and all-atom MD reveal atomistic and residue-level drivers of phase separation, charting the path ahead for simulating complex condensate systems.
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From sequence to mechanism: Enzymology is being transformed by metagenomics, structural biology, and AI. This COSB perspective explores how disordered regions, mechanistic bioinformatics, and in silico catalysis are redefining our understanding of enzymes.
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New COSB review unpacks cutting-edge tools to predict 3D structure & binding affinity in protein–DNA/RNA complexes—essential for understanding gene regulation & repair.
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#bioinformatics #proteinDNA
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From noisy data to molecular insights: simulation-based inference (SBI) is revolutionizing single-molecule experiments with Bayesian frameworks + deep learning. Explore how SBI bridges models and reality.
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#SingleMolecule #MachineLearning
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Missense protein variants shape disease outcomes, but mechanisms are elusive. This COSB review highlights structure-based ensemble frameworks linking amino acid substitutions to stability, interactions & regulation.
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#genomics #precisionmedicine
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Proteins are finely tuned machines—mutations far from the active site can shift dynamics and allostery. Learn how to design function via conformational landscapes.
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#proteinengineering #allostery #COSB
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Amyloid aggregation is complex, and so are its intermediates. New insights into their heterogeneity could unlock therapies for neurodegenerative diseases.
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#amyloids #neurodegeneration #COSB
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Dynamic IDPs, complex binding modes, and AI tools like AlphaFold are shaping a new era in protein interaction studies. This COSB review explores it all.
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#IDPs #AIinBiology #structuralbiology
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Check out our latest article collection on Folding and Binding (2025), guest edited by Yana Bromberg and Benjamin Schuler!
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From static snapshots to dynamic ensembles—advances in RNA modeling are bridging in vitro insights with cellular function, accelerating RNA biology and therapeutic discovery. #RNA #EnsembleModeling #StructuralBiology #COSB
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Unlocking RNA dynamics with molecular rulers! Learn how EPR, FRET, and XSI—enabled by unnatural base pair labeling—are revealing the structure and flexibility of large RNAs like flavivirus genomes. #RNA #StructuralBiology #MolecularRulers #COSB
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