LinXingChen@ChenLinxing

We study microbes and their infecting viruses in natural and host-associated ecosystems using meta-omics approaches.

 Hefei, China
researchgate.net/profile/Lin…
Joined April 2016
We identify conjugative megaplasmids in the human gut that embed intact temperate prophage genomes and may enable cross-lineage viral dissemination.   We propose a plasmid-mediated route for temperate phage spread. biorxiv.org/cgi/content/shor…
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Together, our findings support a model in which conjugative megaplasmids transfer intact prophage genomes across bacterial lineages, decoupling lysogenic spread from infective host range. Experimental validation will clarify the ecological impact of this route.
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We sincerely thank all the authors for their invaluable contributions and support.
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A prevalent huge phage clade in human and animal gut microbiomes biorxiv.org/content/10.1101/… #biorxiv_micrbio

A prevalent huge phage clade in human and animal gut microbiomes

Huge phages are widespread in the biosphere, yet their prevalence and ecology in the human gut remain poorly characterized. Here, we report Jug (Jumbo gut) phages with genomes of 360-402 kilobase...

biorxiv.org
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📢 Preprint out. We are delighted to share our recent work regarding jumbo phages (or huge phages) from the Chen Lab at USTC, The hidden prevalence and unique protein folds of huge phages, which is available at bioRxiv, biorxiv.org/content/10.1101/…

The hidden prevalence and unique protein folds of huge phages

Huge phages are remarkable for their expansive genomes (≥200 kbp, and up to 841 kbp to date), global distribution, and intricate functional repertoires. However, their study has been hindered by...

biorxiv.org
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Additionally, 3% of the HPDB clusters were absent in other viral forms, including the plasmid-originated ArdC that could protect huge phages from the antiviral mechanisms of their hosts. HPDB contains thousands of other huge phages specific structures.
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We hope that HPGC and HPDB can serve as indispensable references for viral ecology and structural biology analyses and could make the study of huge phages easier in the future. Any comments or suggestions on the preprint are appreciated.
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