Chromosome Dynamics group @CNIOStopCancer
Madrid, Spain
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(1/6) NIPBL is required to fuel loop extrusion by cohesin. Is it also required for cohesin loading?
We explore this question in a new preprint from the Losada Lab at @CNIOStopCancer posted in BioRxiv
biorxiv.org/content/10.1101/…
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Losada Lab retweeted
New article from the lab: cell.com/cell-reports/fullte… A brief, 6-tweet summary follows (1/6)
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Losada Lab retweeted
Last two days to apply and join the lab as postdoc fellow! #singlecell #3Dgenome #enhancer #plasticity #glioblastoma #cancerneuroscience
📢 2-year postdoc position!!
Join us @Remeseiro_Lab to study #3DGenomics & #CellularPlasticity in #Glioblastoma #CancerNeuroscience. If you have background in #singlecell #omics and/or #bioinformatics, you're a good match to our team. Apply now 👇👇
Please RT RT RT 🤗
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Losada Lab retweeted
📢 2-year postdoc position!!
Join us @Remeseiro_Lab to study #3DGenomics & #CellularPlasticity in #Glioblastoma #CancerNeuroscience. If you have background in #singlecell #omics and/or #bioinformatics, you're a good match to our team. Apply now 👇👇
Please RT RT RT 🤗
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Losada Lab retweeted
Tomorrow and invited by Ana Losada, @ChromDyn, Oscar Martinez will be at #CNIOStopCancer to speak about multi-omic approach to decipher the molecular mechanisms associated to #EwingSarcoma metastasis using a spontaneous metastasis mouse model.
👏Looking forward to it!
If you want to learn a little bit about #metastasis on #ewingsarcoma stop by @CNIOStopCancer at 3 PM. I'll be explaining our latests results to understand this process. You are invited!! #research #curesarcoma #childhoodcancer @idibell_cat @ASEICAnews
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We are hiring!!!! 📢
We offer a 4-year FPI fellowship to work on Cohesin and 3D genome organization at @CNIOStopCancer.
Please send your CV and a motivation letter to alosada@cnio.es
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Losada Lab retweeted
How is DNA packaged inside cells?
The third dimension of the genome may harbor new cancer treatments.
#CFM_Genome
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We have been thinking a lot about NIPBL and cohesin lately…🤔
NIPBL and cohesin: new take on a classic tale dlvr.it/SmdjWN
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Losada Lab retweeted
👉Third session #CFM_Genome about genome dynamic and stability.
👥With: @davegilbert19, from @SanDiegoBiomed and @marieprioleau from @IJMonod.
📋Inscriptions: bit.ly/3JhDqjc
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Finally out in @NatureComms!🥳
Is NIPBL required for cohesin loading in mammalian cells?
Why do STAG1 and STAG2 cohesin complexes respond to NIPBL KD in opposite ways?
Satisfy your curiosity in nature.com/articles/s41467-0…
(1/6) NIPBL is required to fuel loop extrusion by cohesin. Is it also required for cohesin loading?
We explore this question in a new preprint from the Losada Lab at @CNIOStopCancer posted in BioRxiv
biorxiv.org/content/10.1101/…
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Congrats to everyone involved👏
@dacil_ag, @Cuadrado4Ana, @DanielGLL_ and Miriam Rodriguez!
@CNIOStopCancer
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Losada Lab retweeted
The website of the Cohesinet MSCA Doctoral Network is now ready !!!
Check out it for more info about our consortium and 12 PhD positions available to study cohesin biology and related diseases.
Do not miss this opportunity. Deadline is on 1st of April.
cohesinet.eu
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(1/6) NIPBL is required to fuel loop extrusion by cohesin. Is it also required for cohesin loading?
We explore this question in a new preprint from the Losada Lab at @CNIOStopCancer posted in BioRxiv
biorxiv.org/content/10.1101/…
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(5/6) We propose a new model in which cohesin does not need NIPBL for chromatin association but it does for loop extrusion.
While cohesin-STAG1 binds at CTCF sites and becomes stabilized rapidly, cohesin-STAG2 bind elsewhere and require NIPBL in order to reach CTCF positions.
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(6/6) Great work led by Dácil Alonso Gil @dacil_ag with major contributions from Ana Cuadrado @Cuadrado4Ana, Daniel Giménez Llorente @DanielGLL_ and Miriam Rodríguez Corsino.
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🧬Check out our latest contribution to current understanding of cohesin dynamics. A joint effort from past and current group members!
@CNIOStopCancer
epigeneticsandchromatin.biom…
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Happy to see it out!! Fantastic collab with @MigManzanares lab, great work led by @MajoAndreu 👏👏
New paper from @MigManzanares lab @CBMSO_CSIC_UAM out today in @CellReports! Together with Ana Losada’s lab @ChromDyn @CNIOStopCancer and led by @MajoAndreu, we studied CTCF in early mouse development (cell.com/cell-reports/fullte…) 1/n
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Losada Lab retweeted
New paper from @MigManzanares lab @CBMSO_CSIC_UAM out today in @CellReports! Together with Ana Losada’s lab @ChromDyn @CNIOStopCancer and led by @MajoAndreu, we studied CTCF in early mouse development (cell.com/cell-reports/fullte…) 1/n
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