Laboratory for breast cancer metastasis. Chao Family Comprehensive Cancer Center, UC Irvine
Irvine, CA
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Great time so far at the Fusion #CancerImmuno conference in the beautiful backdrop of Portugal 🇵🇹
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Devon Lawson retweeted
Why is multi-organ #metastasis so hard to treat? Is it organ ("soil")-specific or is there a #systemic program we’ve missed? 🚨 Our new preprint on @biorxiv_cancer reveals a universal, targetable niche conserved across the body. biorxiv.org/content/10.64898… 🧵👇
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Devon Lawson retweeted
Immensely grateful of this team effort! Thanks to @DLawsonlab & @KessenbrockLab fellows, collaborators at @UCIrvineHealth @UCIMedSchool @UCIrvine @CCBS_UCI, @masrilab, @cholsoon_jang, support from @AvHStiftung; @MetastasisRS, @ASEICAnews; and metastatic breast cancer #patients.
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Devon Lawson retweeted
MD Anderson researchers developed a new single-cell DNA and RNA sequencing technology to identify ancestral breast cancer cells.
How this can help gain understanding on why some breast cancers are more aggressive than others: spr.ly/6012A8cXg @nicholas_navin #EndCancer
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Devon Lawson retweeted
Excited to share the preprint of my doctoral work investigating the role of placental development gene PHLDA2 in breast cancer metastasis @DLawsonlab
PHLDA2 promotes breast cancer metastasis by co-opting a developmental program for placental vascular remodeling biorxiv.org/content/10.1101/… #biorxiv_cancer
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Devon Lawson retweeted
PHLDA2 promotes breast cancer metastasis by co-opting a developmental program for placental vascular remodeling biorxiv.org/content/10.1101/… #biorxiv_cancer
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Check out our new paper identifying the developmental gene PHLDA2 as a robust driver of breast cancer metastasis! Thanks to @PHalasPhD @hannysavage @_DennisMa @KessenbrockLab for all their hard work, and support from @AmericanCancer, @theNCI, & Team Michelle. @UCIMedSchool
PHLDA2 promotes breast cancer metastasis by co-opting a developmental program for placental vascular remodeling biorxiv.org/content/10.1101/… #biorxiv_cancer
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So proud of our lab for attending the Stand up for Science rally in Los Angeles yesterday. You will make a difference ❤️ @NafPascal @isam_adam1 @hannysavage @KessenbrockLab @UCIrvine
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Great talk by postdoc @JInsuaRodriguez at the UCI Institute for Immunology annual symposium, describing his work on the role of metastasis associated macrophages in promoting systemic metastasis through immune suppression. @KessenbrockLab @UCIMedSchool
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Devon Lawson retweeted
New paper from our group in @Nature by @YiyunLin_YL @junkewang @KaileWang and team reporting the unexpected discovery of aneuploid epithelial cells (3%) in normal breast tissues from healthy women raising the question of when is cancer really cancer?
nature.com/articles/s41586-0…
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I’m teaching a class on single cell omics in cancer. What would you pick as some of the most breakthrough discoveries in cancer using single cell tools to date? 😉
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Devon Lawson retweeted
We are only one month away from the @GordonConf GRC+GRS in Single-Cell Cancer Biology!
We have a fantastic program lined up! A few spots left. Register now!
🔥 GRS: June 8-9 (early career)🔥
grc.org/single-cell-cancer-b…
🔥 GRC: June 9-14 (main conference) 🔥
grc.org/single-cell-cancer-b…
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Congrats to Paige Halas @FuturePHPhD for being selected as a finalist to compete in UCI’s Grand Slam championship! She did an outstanding job in her elevator pitch (3min!) describing her work on how specific genes promote metastasis to lay audiences!#UCIGrandSlam @UCIMedSchool
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Congrats to Katrina and Aaron on a beautiful cover image! 5 color immunofluorescence using CODEX shows that pro-inflammatory microglia infiltrate growing metastatic lesions in the brain.
🎄Our last issue for 2023 is live!
Cover: #tumor suppressive #microglia
👉🏽Comments on #embryomodels and #CellDeath
👉🏾🔬on: #BreastCancer #BoneMarrow #SkeletalMuscle #NucleotideMetabolism #SenescentCells #pyroptosis & more!
👉🏼Method: #epigenome profiling
nature.com/ncb/volumes/25/is…
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Devon Lawson retweeted
💫NEW: @DLawsonlab & co identify and characterize a #tumour-suppressive role for #microglia that mediates a pro-inflammatory response to restrict brain #metastasis in #BreastCancer. #CancerResearch
rdcu.be/dr33v
nature.com/articles/s41556-0…
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Check out our new single cell datasets! We posted interactive UMAPs on our lab website lawsonlab.org, from our recent paper in @NatureCellBio where we found that microglia promote anti-tumor immunity and suppress brain metastasis. Check out expression of your fav genes!
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I'm so pleased to share our new study out today in @NatureCellBio where we found that brain resident microglia promote anti-tumor immunity to suppress breast cancer brain metastasis @UCIMedSchool nature.com/articles/s41556-0…
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scRNAseq analysis showed that microglia mount a pro-inflammatory response to metastatic infiltration. GEM mice lacking microglia show increased metastasis, decreased survival and reduced natural killer and T cell responses that are critical to suppress tumor outgrowth in the CNS.
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Congrats to first authors Katrina Evans, Kerrigan Blake, Aaron Longworth and coauthors @JInsuaRodriguez @_DennisMa @graceah9 @VillaltaLab @BlurtonJonesLab @CPridans for >6yrs of hard work, and @ACS_Research & @theNCI for critical funding.
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