Darius McArdle retweeted
Check out this amazing work spearheaded by our very own @bailey_elliot! Congratulations to Elliot for making great strides in hydrogen borrowing @OxfordChemistry
nature.com/articles/s41467-0…
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Darius McArdle retweeted
Our work investigating the functional group tolerance of the hydrogen borrowing enolate alkylation method now out in full form! @MDSgroup_Oxford @DonohoeGroup
@OxfordChemistry @OxfordSynthesis
nature.com/articles/s41467-0…
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Darius McArdle retweeted
Very pleased to share that my PhD work from @UniofOxford/@synbioCDT with @conway_group is now live on BioRxiv - we designed pairs of orthogonal IMiD analogues and ZF degrons for use in target validation & beyond. biorxiv.org/content/10.1101/…
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Darius McArdle retweeted
Very exciting to see @KlemSimelis’ #phdresearch on targeting TET #enzymes using #cyclicpeptide inhibitors in #Bioorganic & #MedicinalChemistry!
A great collaboration with the Suga group & @SchofieldOxford.
Read Klem's paper online: sciencedirect.com/science/ar…
#chemicalbiology
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Delighted to share our paper targeting a bromodomain of S. mansoni! Thanks to everyone involved. I look forward to seeing future work from the Conway and Hoffmann group collaboration!
Our paper on inhibitors of the Schistosoma mansoni bromodomain SmBRD3(2) is online in J Med Chem (@ACSBioMed). Congrats to @MatthiasSchied2, @DMcardleChemBio, @gilda_padalino, @anthonyknc and the other authors. Great (ongoing) collaboration with @ProfHoff1 pubs.acs.org/doi/10.1021/acs…
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Darius McArdle retweeted
Our paper on inhibitors of the Schistosoma mansoni bromodomain SmBRD3(2) is online in J Med Chem (@ACSBioMed). Congrats to @MatthiasSchied2, @DMcardleChemBio, @gilda_padalino, @anthonyknc and the other authors. Great (ongoing) collaboration with @ProfHoff1 pubs.acs.org/doi/10.1021/acs…
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Darius McArdle retweeted
Here's a bit more detail on this paper. When discussing our work on NI-Pano (sciencedirect.com/science/ar…) we were often asked how we knew where the prodrug was being released. So we designed a new prodrug incorporating the fluoroethyl epitope of the antibody-based...
Our work on Antibody-Based Imaging of Bioreductive Prodrug release now online in @JACS_Au! We developed a modified version of the nitroimidazole bioreductive group that incorporates the fluoroethyl epitope of the antibody-based hypoxia imaging agent, EF5. pubs.acs.org/doi/10.1021/jac…
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Darius McArdle retweeted
In @ChemRxiv we (in collaboration with
@MDSgroup_Oxford) show that hydrogen borrowing can be a remarkably mild and functional group tolerant process: bit.ly/46QXWRh Well done
@bailey_elliot, @OxfordChemistry, @OxfordSynthesis
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Darius McArdle retweeted
(1/8) Please to present our work on functional group tolerant C-C bond forming hydrogen borrowing enolate alkylation reactions with @MDSgroup_Oxford @DonohoeGroup @OxfordChemistry @OxfordSynthesis:
bit.ly/46QXWRh
In @ChemRxiv we (in collaboration with @DonohoeGroup) show that hydrogen borrowing can be a remarkably mild and functional group tolerant process: bit.ly/46QXWRh Outstanding stuff from @bailey_elliot @OxfordChemistry @OxfordSynthesis
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Darius McArdle retweeted
Hot off the press! Check out our ‘mutate and conjugate’ paper in @ACSBioMed 🔥
Here we demonstrate that combining site-directed mutagenesis and reactive fragments can be used to rapidly identify selective covalent probes for target validation studies.
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Darius McArdle retweeted
Our pre-print on the development of ligands for a bromodomain-containing protein from Schistosoma mansoni is now available @ChemRxiv.
We have identified ligands for both bromodomains from SmBRD3, and used a structure-based approach to optimize them. chemrxiv.org/engage/chemrxiv…
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Darius McArdle retweeted
We are very proud of Jess Reynolds for winning the prize for the best talk (& title of European Champion!) at the @EuroMedChem YMCS meeting. She won the best talk at the @RSC_BMCS meeting last year to go forward to the Champions League in Basel! @OxfordSynthesis @OxfordChemistry
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Great to meet @ProfHoff1 this week at the University of Aberystwyth. Looking forward to work ahead!
Great talking with @conway_group about schistosome epigenetics and drug discovery. Looking forward to our future @ibers_aber @UniofOxford collaboration and a recripocal visit!
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Darius McArdle retweeted
Here it is, our @ChemCommun front cover! A huge thanks to @KarlnHarrison for making it possible! @LabMcDonald @mljones1993
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