We are proud to announce new findings from a retrospective ancillary analysis of the randomized phase III NRG/RTOG 0815 trial.
The results, which will be presented at the
#ASTRO26 Annual Meeting (Abstract #312), demonstrate that the Decipher® Prostate Genomic Classifier can predict which patients are more likely to benefit from adding short-term androgen deprivation therapy (ADT) to dose-escalated radiation, providing Level 1B* prognostic and predictive evidence.
| Impact |
The findings provide the first evidence that Decipher testing can predict hormone therapy benefit in intermediate-risk prostate cancer, extending its long-established role in assessing the risk of prostate cancer progression to informing treatment selection for patients with intermediate-risk disease.
While ADT can reduce the risk of recurrence and distant spread, it can also have metabolic and quality-of-life effects. Because intermediate-risk disease is biologically diverse, clinical variables such as Gleason grade, prostate-specific antigen (PSA) or clinical stage alone may not reveal which patients are most likely to benefit from adding the therapy.
The NRG/RTOG 0815 trial analysis helps move
#DecipherProstate testing closer to answering a consequential question in prostate cancer care: Will hormonal therapy make a meaningful difference for this patient? Study author, Angela Jia, M.D., Ph.D. will present the results.
| Presentation Details |
📅 Date: Tuesday, September 29
⏰ Time: 3:55pm – 4:05pm ET
📍 Location: Room 210
*Simon, R. M., Paik, S. & Hayes, D. F. Use of archived specimens in evaluation of prognostic and predictive biomarkers. J Natl Cancer Inst 101, 1446–1452 (2009).
doi.org/10.1093/jnci/djp335
| Resources|
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