For all those supporting high quality healthcare. Turning real world evidence into real world outcomes.
Birmingham, U.K.
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A target trial emulation study compared SGLT-2i with DPP-4i across 59 long-term conditions in people with T2DM. SGLT-2i use was linked to a lower risk of all-cause mortality, alongside reduced risk across a broad range of conditions.
#Diabetes
academic.oup.com/ejendo/adva…
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A study investigated 10 pregnancy complications with later CVD, T2DM, high blood pressure, and CKD. The takeaway: take a full reproductive history and use the postpartum period as a window for risk assessment and prevention.
#BMJMedicine
bmjmedicine.bmj.com/content/…
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A study found that fenofibrate was associated with a 13-20% lower risk of sight-threatening diabetic retinopathy compared with statins in people with T2DM suggesting it could be a useful preventive therapy for diabetic eye disease.
#Type2Diabetes
academic.oup.com/jcem/advanc…
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A new study found that pre-pregnancy migraine was not associated with overall preterm birth but was linked to increased odds of iatrogenic preterm birth and pre-eclampsia, though the underlying mechanisms remain unclear.
#Migraine #Obstetrics
link.springer.com/article/10…
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A study demonstrated that Behçet's syndrome prevalence in England nearly doubled, from 8.62 to 19.80 per 100,000, while incidence stayed flat. Genital ulceration was the strongest clinical marker and led to the fastest diagnosis (median 240 days).
#BMJ
rmdopen.bmj.com/content/12/3…
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A study found a delay of 3.6 years between symptom presentation and confirmed eosinophilic oesophagitis diagnosis (EoE). The study highlightes substantial diagnostic latency across UK primary and secondary care pathways.
#EoE #BMJ
fg.bmj.com/content/early/202…
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A study investigated patients starting statins and found that having a QRISK score was linked to modestly better medication adherence and persistence. There was also a 15% reduction in CVD events and death, that drop requires further investigation.
journals.sagepub.com/doi/ful…
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A study found that England's NHS primary care funding formula is driven mainly by age, deprivation, and region. When researchers modelled a morbidity inclusive funding approach, the redistribution was modest overall.
#NHS #HealthPolicy #PrimaryCare
bmjopen.bmj.com/content/16/6…
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A study found that nearly half of high-risk COVID-19 patients developed long COVID during the Omicron era. The findings highlight a burden on primary care systems and the need for better recognition and targeted long COVID strategies.
#LongCOVID
link.springer.com/article/10…
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A study measured how much depression scores naturally fluctuate within the same patient over time. The findings show substantial within-individual variation and counterintuitively the variation shrinks as scores get higher.
#Depression
sciencedirect.com/science/ar…
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A study found that recurrent sore throat or tonsillitis patients tend to be younger, female, and from more deprived areas. Tonsillectomy was rare and poorly matched to actual need, the majority of eligible patients never received it.
#Tonsillectomy
medrxiv.org/content/10.64898…
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A new study found that maternal autoimmune diseases are associated with a higher risk of adverse pregnancy outcomes, including miscarriage, pre-eclampsia, preterm birth, stillbirth, and perinatal mental health conditions.
#MaternalHealth
link.springer.com/article/10…
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Researchers have developed a framework designed to predict patient survival outcomes from incomplete EHRs without relying on data imputation. The system learns patterns directly from gaps in the data.
pmc.ncbi.nlm.nih.gov/article…
#RWE
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Researchers have developed “SurvivEHR”, a transformer-based AI model trained to better predict how multiple chronic conditions develop over time. The authors say the system could help clinicians produce more personalised risk forecasts.
nature.com/articles/s41746-0…
#RWE
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Last week, we were delighted to lead a Datathon with the West Midlands Secure Data Environment. Four secondary care studies across acute and maternal care were completed in just one day, covering topics from quality improvement to risk prediction and pharmacoepidemiology.
#RWE
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Dexter featured in the recent NHS West Midlands Secure Data Environment stakeholder summit. It was a fantastic opportunity to explore collaboration with partners and contribute to the ongoing conversation around the future of secure, data-driven healthcare.
#HealthData #NHS
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A study found that fit notes for work have increased, with mental health conditions such as depression and anxiety accounting for a substantial share of certifications. The total economic cost rose from £13.3 billion to £15.9 billion over this period.
pmc.ncbi.nlm.nih.gov/article…
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A new study developed a prognostic score to predict the two-year risk of respiratory hospital admissions in people with chronic obstructive pulmonary disease (COPD).
#COPD #BMJ #RespiratoryHealth
bmj.com/content/392/bmj-2025…
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A Dexter study found that HbA1c levels vary within individuals over time, with an overall coefficient of variation of about 0.20. Variation was greater in people with prediabetes or diabetes and in certain demographic or clinical subgroups.
#diabetes
pmc.ncbi.nlm.nih.gov/article…
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