The Fallopian Tube’s Secret Bodyguards 🛡️ I am thrilled to share our lab’s latest study which flips the script on how we think about the origins of ovarian cancer. For a long time, ciliated cells in the fallopian tube were seen as "passive bystanders" in tumor development. Our research reveals they are actually active guardians of genomic integrity. We found that these cells use a STING-driven surveillance mechanism to act as a biological "cleanup crew," clearing away damaged cells before they can turn into high-grade serous carcinoma (HGSC). When these "gatekeepers" are lost, the door swings wide open for cancer to initiate. This discovery shifts our understanding of the epithelial microenvironment and points toward new strategies for early prevention. aacrjournals.org/cancerres/a… @UMich @UMRogelCancer @CR_AACR @UMichPath

Congratulations Dr. Puleo ⁦@Noah_Puleo⁩ on successfully defending your PhD thesis. It was a pleasure mentoring you and seeing you evolve into an accomplished scientist and leader. Good luck on your next endeavor and I’m excited to see your many future successes.

What a crew!! Happy Holidays from our team to yours!! @TeitelJessica @Noah_Puleo @amandapearrl

What an amazing Ovarian Cancer conference @RivkinCenter @AACR It is remarkable to see so many passionate scientists, physicians, and patient advocates coming together to work on finding a cure!

Always great to see a newly minted PhD from #UMICHCancerBioProgram passing the passion for science on to the next generation ⁦@B_B_Beast⁩ @UMRogelCancer⁩ ⁦@umichmedicine⁩!!!

Congratulations Zoe Jackson on your Barry Goldwater scholarship Nomination ⁩ ⁦⁦@UMich⁩ #womeninstem

DiFeo lab is sending positive vibes to our team! #GoBlue @UMichFootball @UMichPath @UMich @umichmedicine @UMRogelCancer

Thanks to organizers of OvCa Midwest Focus #OCMF for organizing an exceptional meeting. Congrats to the entire lab @Noah_Puleo for presenting your work with remarkable intelligence and passion esp. @TeitelJessica for winning best oral! You all make me proud! Passion=progress.

It was great to be able to share our research team’s discoveries and host a lab tour for @MIOvarianCancer MIOCA. With passion comes progress and our collaboration will continue to push for more research, improved awareness, and better treatments!

When your passion for staying fit and ovarian cancer research come together -let's support @Noah_Puleo an brilliant @UMichPath graduate student running his 1st Half marathon to raise money for ovarian cancer research @MIOvarianCancer givengain.com/ap/noah-puleo-…

It was an honor to advocate for more funding for cancer research on Capital Hill. #teamworkmakesthedreamwork @UmichCancBio @UMRogelCancer @DiFeoLab #FundNCI #FundNIH #AACROnTheHill #AACIOnTheHill

I am so fortunate to do what I love #cancerResearcher but what makes it even better is that I do it with an intelligent and passionate amazing team!! @TeitelJessica @Noah_Puleo Thanks for the awesome gift #M&Ms and looking forward to our @FowlingAnn rematch!

I couldn’t be more proud of the @DiFeoLab @TeitelJessica @Noah_Puleo for the amazing job they did presenting their work at #OCMF Thanks to the organizers-so excited for new collaborations and new discoveries @ronny_drapkin @BazzaroPhd

So proud of the @DiFeoLab @McAnultyJessica @Noah_Puleo & @UmichCancBio @B_B_Beast for supporting ovarian cancer research and participating @MIOvarianCancer Teal Fun Run! It was great to be able to share this special day with cancer warriors, researchers, my lab, parents, & kid’s.

Great to see such interest in Rita Avelar’s work on PP2A modulators and PARPi for the treatment of high grade serous cancer. #AACR22 #teamwork @NarlaLabUMich @CDMRP funded

As co-chair for the ACS 2022 ResearcHERS campaign, help me "Pass the Passion" to the next generation of women who want to pursue a career in cancer research. #WomeninSTEM Please join me in donating here: main.acsevents.org/goto/anal…

Enjoying Robert G. Roeder @RockefellerUniv Keynote Lecture @UMichPath . It is amazing that his original manuscript describing the RNA Pol I, II & III was initially rejected from Nature b/c not general interest!?!?!? Luckily, after much convincing it was accepted!#sciencestruggles

Very proud of Jessica McAnulty from our lab @DiFeoLab! She gave an outstanding talk on new ovarian cancer specific drugs we have uncovered at the Training Program in Translational Research Annual Retreat! @UMRogelCancer @UMichPath #WomenInScience @umichgradschool

What an honor to work with this amazing group of scientist dedicated to ovarian cancer research!@karenmcl13 #AACROvCA19 #GoBlue @UMRogelCancer @umichmedicine