Biochemist and Chemical Biologist Postdoctoral Research Fellow, Kranzusch Lab Dana-Farber Cancer Institute, Harvard Medical School
Boston, MA
- Tweets 29
- Following 162
- Followers 127
- Likes 47
An elegant and easy-to-use method for generating new biochemical assays for difficult proteins. Proof that dyes can be versatile and specific chemical probes. Congratulations Taia!
What do you do when there's no assay for your protein's activity? Dyes might help! Excited to share protein-adaptive DSF (paDSF), a versatile new dye-based method to create stability assays on-demand.
biorxiv.org/content/10.1101/…
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I'm so excited to share this work! We combine chemistry and genetics to inhibit mTOR in specific tissues. We hope this will be a useful tool for anybody who is interested in mTOR and rapamycin in aging, immunity, metabolism, and more!
biorxiv.org/content/10.1101/…
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Doug Wassarman retweeted
Thrilled that my PhD #research with @GestwickiLab is out in @NatureComms - rdcu.be/cIBbf! Here, we describe new criteria for activating protein degradation by the proteasome. Grateful for collaborators in @salilab_ucsf & @LanderLab, particularly @andyhernandy...
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Doug Wassarman retweeted
Three Essential Resources to Improve Differential Scanning Fluorimetry (DSF) Experiments biorxiv.org/cgi/content/shor… #bioRxiv
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Doug Wassarman retweeted
Thank you to everyone who came to our networking mixer on Friday and to our keynote speaker Dr. Jason Sello for emphasizing the importance of mentorship in academia and prioritizing happiness in our science. Let's continue to uplift and support each other!
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Doug Wassarman retweeted
Very excited to have @bignerdzzy’s work targeting K-Ras with new bifunctional molecules published in @angew_chem. Thank you to our editor Dr. Godinho and the reviewers for their expertise and rapid reviews! @UCSFCancer @UCSF @NCIResearchCtr @DamonRunyon
@kevansf & Ziyang Zhang @UCSF describe bifunctional #SmallMolecule ligands of K-Ras that induce its association with immunophilin proteins, #DrugDesign doi.wiley.com/10.1002/anie.2…
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Doug Wassarman retweeted
Shokat lab over here crushing it with their social hour poster. @kevansf
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Very cool work from Michael Lin's group @Stanford_ChEMH: Turning cancer's oncogenic signaling against itself by using those signals to initiate apoptosis with synthetic proteins.
science.sciencemag.org/conte…
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Wonderful work from an incredibly talented post doc! @bignerdzzy
Bifunctional Small Molecule Ligands of K-Ras Induce Its Association with Immunophilin Proteins biorxiv.org/cgi/content/shor… #bioRxiv
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Congratulations to @RyanKMuir with @adamrenslo and @mikeevans_ucsf labs. Really cool approach, using an iron-reactive PET probe to image tumors that contain high levels of labile ferrous iron.
UCSF laboratories of @adamrenslo and @mikeevans_ucsf describe a small molecule PET reagent for imaging the disposition of labile ferrous iron in animals. @UCSF @UCSFimaging @ucsfpharmacy
pubs.acs.org/doi/full/10.102…
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Doug Wassarman retweeted
Take a look at my 3 minute Grad Slam talk that I gave a couple of weeks ago! Turns out the hardest part of grad school is summing up 5 years of research in only 3 minutes... #GradSlam
piped.video/watch?v=XzCL0h…
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Nice review on the role of metabolism in immune cell activation. It highlights how metabolic changes support the energetic and biosynthetic needs associated with activation of different immune cells.
jbc.org/content/291/1/1
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Doug Wassarman retweeted
The RNA helicase UPF1 associates with mRNAs co-transcriptionally and is required for the release of mRNAs from gene loci elifesciences.org/articles/4…
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What an incredibly useful guide! I wish this was around for my undergrad lab courses.
Very happy to say that my illustrated Schlenk line chemistry guide is finally online! Please share with your friends/colleagues/students and let me know what you think!
schlenklinesurvivalguide.com
#RealTimeChem #SciArt #ChemTwitter
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This just taught me about a really cool method for protein engineering: circular permutation. Check it out! These folks use it to create caged versions of Cas9 that are activated by viral proteases and help restrict viral infectivity.
sciencedirect.com/science/ar…
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It’s always exciting to see drug candidates with novel mechanisms of action move into clinical trials! Hopefully this is just the first of many #PROTAC
Chemical Biology Comes of Age- it's been great to shepherd our academic chemical biology idea from concept to the clinic over the past twenty years. My hopes have long been for #PROTACs to have a clinical benefit for patients. Good luck @Arvinas! globenewswire.com/news-relea…
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A mucin-selective protease! Amazing work to show that StcE is selective for the O-GalNAc in mucins, and then use it differentiate the mucin-binding of Siglec-7 and Siglec-9.
Hot off the press!! Check out the work @KayvonPedram and I did to characterize StcE, a mucin selective protease. Very excited to see this in print!! @CarolynBertozzi #glycotime #PNAS pnas.org/content/early/2019/…
Doug Wassarman retweeted
A #Legionella pneumophila kinase, LegK4, phosphorylates the Hsp70 chaperone family to inhibit eukaryotic #proteinsynthesis. New from Mukherjee lab, @StevenMoss24 @kevansf cell.com/cell-host-microbe/f…
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Doug Wassarman retweeted
Six female researchers discuss how they overcame social and financial obstacles in science and engineering. go.nature.com/2Xc8oPG
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