Small bicyclic amine systems form strained molecular skeletons, leading unique reactivity as well as geometric and dynamic features: bit.ly/4BasP2u Try our strained amines in your research!

Join us at these upcoming conferences: - The 129th Symposium on Organic Synthesis, November 5-6, Tokyo, Japan ssocj.jp/event/129symposium/ - Bio-Europe, November 9-11, Cologne, Germany informaconnect.com/bioeurope… - SMART Symposium on Targeted Protein Degradation 2026, November 10-13, Shenzhen, China symposia.smart.org.cn/sym/ar… We will be happy to meet you, discuss the latest developments in Drug Discovery, and explore new opportunities for collaboration.

Join us at the 9th TPD & Induced Proximity Summit on October 26–29 in Boston, MA! We will be happy to meet you, discuss the latest developments in Drug Discovery, and explore new opportunities for collaboration. proteindegradation.com/

Molecule of the week EN300-55116438 enaminestore.com/catalog/EN3… Discover all the molecules of the week here: enamine.net/molecule-of-the-… #Enamine #molecule #chemistry #science #drugdiscovery

Join @cressetgroup and Enamine for the webinar “Finding the Perfect Link: Computational Strategies for Next-Generation Protein Degraders” on November 4 at 11 AM EST. Explore how computational approaches can help address the challenges of degrader design, from target engagement and linker architecture to ternary complex formation and molecular properties. The webinar will also cover how Enamine Ltd.’s building block capabilities can help uncover new design opportunities. Don’t miss this opportunity - register now: us02web.zoom.us/webinar/regi…

Join us at these upcoming conferences: - Al Drug Discovery & Development Summit, October 27-29, Boston, MA aidrivendrugdevelopment.com/ - The 52nd Symposium on Progress in Organic Reactions and Syntheses, October 31- November 1, Tokyo, Japan k-gakkai.jp/sympo52/en_index… We will be happy to meet you, discuss the latest developments in Drug Discovery, and explore new opportunities for collaboration.

Please welcome Olexander Zadorozhny - the chemist behind the molecule of this week. Congratulations!👏 enaminestore.com/catalog/EN3… Discover all the molecules of the week here: enamine.net/molecule-of-the-… #Enamine #molecule #chemistry #science #drugdiscovery

We are pleased to announce the new release of Enamine REAL! Enamine REAL Database: 𝟏𝟔.𝟏 billion molecules; Enamine REAL Space: 𝟏𝟏𝟔.𝟑 billion molecules. The REAL Compounds provide an ideal solution for hit finding in ultra-large docking and AI-driven Drug Discovery due to the following advantages: - Unmatched synthesis success rate (over 80%); - Short synthesis time (3-4 weeks); - Cost efficiency; - Recognized by the scientific community, over 130 publications citing Enamine REAL. Find out more about Enamine REAL: enamine.net/compound-collect…

Mixed haloalkoxy groups have a potential for adjusting protein binding. The concept is exemplified by two recently developed inhibitors of Philadelphia tyrosine kinase asciminib (𝘕𝘰𝘷𝘢𝘳𝘵𝘪𝘴) and embibatinib (𝘔𝘦𝘳𝘤𝘬): bit.ly/4e0mbBX Try our haloalkoxy groups!

Check out the recent paper: “Bench-Stable α-Fluoroamines: Synthesis, Properties, and Application in Medicinal Chemistry”, co-authored by Vadym Levterov, Oleh Shablykin, Oleksandr Stashkevych, Volodymyr Kokhalskyi, Vadym Konashuk, Iryna Sadkova, Olha Shevchuk, Petro Borysko, Henry Rzepa, and Pavel Mykhailiuk (@MykhailiukChem). This study shows that the incorporation of the CH2-group into the elusive α-fluoropiperidine provides a stable α-fluoroamine with the 2-azabicyclo[2.2.1]heptane core. The latter does not eliminate HF because of Bredt's rule. The high stability of this α-fluoroamine allows its wide chemical modifications and use in medicinal chemistry. Read more: doi.org/10.1002/anie.5080799

Molecule of the week EN300-1601712 enaminestore.com/catalog/EN3… Discover all the molecules of the week here: enamine.net/molecule-of-the-… #Enamine #molecule #chemistry #science #drugdiscovery

Nearly half of the 518 protein kinases contain potentially accessible cysteines in or near their ATP-binding pockets. Yet many of these sites remain largely unexplored, offering exciting opportunities for covalent drug discovery. An electrophile-first approach using reactive fragments provides a way to identify covalent binders targeting these sites. Inspired by the work of the research groups of Prof. Stefan Knapp and Prof. Matthias Gehringer (doi.org/10.1002/anie.2024197…), we have expanded the originally reported 47-fragment library into a 240-compound collection using a similar methodology. The expanded library covers a broad range of hinge-binding motifs, linkers, and acrylamide warhead positions. Our library offers promising starting points for the development of highly potent and selective covalent inhibitors. Learn more: enamine.net/compound-librari…

We are excited to announce a long-term strategic partnership with Ewha Womans University (@EwhaWomansUniv) to shorten the path from computational hypothesis to experimentally validated hit and lead compounds. The partnership will build a closed design–make–test–analyze (DMTA) cycle, connecting AI-based drug design with experimental validation. AI models will search and learn from chemical space that Enamine can synthesize, while experimental results will feed back into the next round of designs, helping shorten the path from computational hypotheses to validated hit and lead compounds. The collaboration will also cover synthesizability-aware generative design, ultra-large virtual screening, reaction and property prediction, and the generation of high-quality experimental data for model training, with results published jointly. It will also explore integrated drug discovery offerings that take projects from AI-based design to validated hits and leads for pharmaceutical, biotechnology, and academic partners in Korea and worldwide. Learn more: enamine.net/news-press-relea…