GB@GMBurslem

Chemist/Chemical Biologist. Assistant Professor at Penn (@BB_UPenn). Confused Brit in the US. Views my own. He/him

 Philadelphia, PA
burslemlab.com/
Joined October 2010
128 Photos and videos
The Oct issue of Cell Chemical Biology is a special issue on post-translational modifications with guest editor George Burslem, UPenn. Read reviews & more on how PTMs increase proteoform diversity & add a versatile regulatory layer to protein function. dlvr.​it/TVwr2N
Special issue on PTMs for October issue of CCB, cover image

ALT Special issue on PTMs for October issue of CCB, cover image
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It's been a great couple of weeks for publications from the lab! First up we have a generalizable induced proximity system for gain of function PTM editing exemplified by acetylation and led by @BHillPayne tinyurl.com/ynukee3m

General Strategy for Controlling Functional Lysine Acetylation via Induced Proximity

AbstractAssigning causal function to post-translational modifications (PTMs) remains a central challenge in molecular biology, as most modification events

pubs.acs.org
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New inhibitors of the HDAC6/Ubiquitin protein-protein interaction chemistry-europe.onlinelibra…

Quinazolinone and Phthalazinone Inhibitors of the HDAC6/Ubiquitin Protein–Protein Interaction

Here, we report the validation and expansion of small-molecule inhibitors targeting the HDAC6 ZnF-UBD pocket. Following molecular modeling, hits were synthesized, and candidate compounds were tested...

chemistry-europe.onlinelibrary.wiley.com
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And new photo-switchable PROTACs from our collaboration with the Trauner lab pubs.rsc.org/md/article/doi/…

Optimizing CRBN-ligands for optical targeted protein degradation

PROTACs are heterobifunctional molecules that modulate protein levels through targeted degradation, eliminating both physiological and pathophysiological f

pubs.rsc.org
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📢 We're pleased to welcome @Fluorochem as a Silver Sponsor of the 34th GP2A Conference on Medicinal Chemistry (#GP2A2026)! Their longstanding support of medicinal chemistry research makes them a great addition to our sponsor community. #MedicinalChemistry #DrugDiscovery
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Excited to share our new @biorxivpreprint from the @BradyLab led by Santanu Ghosh. “Mitochondrial copper stabilizes lipoylated TCA cycle proteins to sustain metabolism and proliferation” biorxiv.org/content/10.64898…
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Thank you to all the friends, collaborators, lab members and mentors who made this happen!
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Lifesaving discoveries stem from the basic science research happening in labs every day. Without critical funding from the U.S. government, new problems will not be addressed. Dr. Sara Cherry explains how this can impact our ability to receive routine care.
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It was a beautiful morning at @UDelaware!
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Cancer researcher Donita Brady, PhD, was recently recognized by @ASBMB for her efforts to maximize access to science, such as leading student programs to “inspire the next generation of potential world-changers.” @bradylabupenn @PennCancer @Penn_CBIO spr.ly/6012AZSrQ
Donita Brady smiling with colleagues in an office.

ALT Donita Brady smiling with colleagues in an office.

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Congratulations to my great friend and colleague @bradylabupenn for this well deserved award! @PennMedCSO @Penn_CBIO
ASBMB@ASBMB
5 Sep 2025
Congratulations to the 2026 ASBMB Award Winners! Through their pioneering work, these scientists are advancing discovery, driving innovation, and shaping the future of molecular life sciences. Read more about their work: ow.ly/x05f50WSbax. #ASBMB26 #MakeItPossible
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Very happy to share this preview in @TrendsinBiotech two cool intein papers just out in @ScienceMagazine by @GMBurslem, @ophirshalem & @MuirLab. Beautifully written by my new postdoc, Kevin Schiefelbien🤩 @Penn @PrincetonChem authors.elsevier.com/a/1lXcK…
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Excited to share our new @ScienceMagazine paper! Led by postdocs Ruchao Peng and Xin Xu, we used cryo-EM/ET to reveal the influenza ribonucleoprotein complex structure and its strand-sliding mechanism for RNA synthesis, paving the way for new antivirals. science.org/doi/10.1126/scie…

Molecular basis of influenza ribonucleoprotein complex assembly and processive RNA synthesis

Influenza viruses replicate and transcribe their genome in the context of a conserved ribonucleoprotein (RNP) complex. By integrating cryo–electron microscopy single-particle analysis and cryo–elec...

science.org
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New preprint with Eddie Lees lab!
Eddie Lee@TNRLab
9 May 2025
Maybe my last Tweet? We found that shifting around polyubiquitin (using a chemical biology trick) results in altered #tau filament structure. The unstructured "fuzzy coat" of tau filaments matters!?! #AD #FTD #FTLD #cryoEM #Alzheimer #VCP #raredisease biorxiv.org/content/10.1101/…
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Check out our work on protein editing!
Science Magazine
@ScienceMagazine
8 May 2025
A pair of split inteins—small protein segments that can undergo a self-sustained protein splicing reaction—enables endogenous protein editing in living mammalian cells, according to a new study in Science. 📄: scim.ag/3ENypj9 #SciencePerspective: scim.ag/430jwC9
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Pairs of split protein segments can modify a variety of target proteins in a living cell @ScienceMagazine @ophirshalem @JennaNBeyer @GMBurslem science.org/doi/10.1126/scie… science.org/doi/10.1126/scie…
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Happy Women’s History Month from @RTAatPennMed @PennMedicine! Check out our events planned for the rest of the month!
Research Trainee Affairs at Penn Medicine@RTAatPennMed
14 Mar 2025
Check out our March newsletter!
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Stand Up For Science this Friday at City Hall!
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