Roderic Guigó's Computational Biology of RNA Processing Lab @CRGenomica
Barcelona, Spain
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🧬💻Excited to share our research from @GuigoLab once again at the XII Jornades de Bioinformàtica i Genòmica!
#transcriptomics #longread #chromatin #transdifferentiation
#JBG2024 #Bioinformàtica #Genòmica
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This week @ArnanCarme is presenting her #CRISPRCas9 tool at #NextGenOmics24, aimed at advancing #singlecell transcriptomics. Don't miss the poster! ✂️👩🔬🧬
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🛶🥾Dia de camp amb l'equip de #Pyrisentinel als espectaculars estanys de Tristaina @ordinoesviu! Gràcies @rosatalamas @saulgrau @som3cat
per capturar aquests moments amb un magnífic reportatge 🤩
@CRGenomica @CREAF_ecologia @Andorra_RI @CNRS @CTPPOCTEFA
🎥ow.ly/lf9C50TwTNX
⛰️🧬🦠Gràcies @som3cat per explicar tan bé el nostre projecte #PyriSentinel, que investiga la biodiversitat de microorganismes en llacs d'alta muntanya!
🙌Amb @Hannah_benisty @RodericGuigo @GuigoLab
Els llacs del Pirineu, sentinelles del canvi climàtic ccma.cat/3cat/els-llacs-del-…
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🌍Excited to share that our lab participated in #ECCB2024 💻🧬 in Turku, Finland last week! @Silvia_Torello from our lab proudly represented GENCODE @GencodeGenes, showcasing our progress in discovering and cataloguing the human and mouse transcriptomes. @CRGenomica #Genomics
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Excited to announce our long-read sequencing methods comparison #LRGASP paper is out! 🎉 It's been a journey since June 2019 at @CRGenomica where everything started. Huge thanks to all involved. @Silvia_Torello @RodericGuigo @julienLag. Can't wait to see its impact! 📊🧬
We are excited to publish our second-ever Registered Report! The #LRGASP Consortium evaluated various methods for transcript identification and quantification using long-read sequencing technologies. @anaconesa @TheSheynkmanLab @TheBrooksLab @calizavi
nature.com/articles/s41592-0…
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Last week we had a great time at the @the_prbb Computational Genomics Symposium 2024, with engaging talks, discussions, and activities by the beautiful Costa Brava sea with our colleagues! ⛵️🌅💻
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La Silvia González-López ha presentat els seus resultats a la XIV Jornada de Cromatina i Epigenètica que organitza la
@SCB_iec 🧬🚀
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🚀 Kickoff meeting for #PyriSentinel, a @CTPPOCTEFA-funded project held in Ordino, at the heart of the Pyrenees.
Excited to begin exploring Pyrenean lakes' microbiome through genomics and contribute to ecosystem conservation 🦠🧬⛰️
@CRGenomica @Andorra_RI @CREAF_ecologia @CNRS
⚡️Arrenca una expedició per cartografiar la biodiversitat invisible dels llacs pirinencs
@Hannah_Benisty és la coordinadora de PyriSentinel, un nou projecte de tres anys finançat per la Unió Europea i coordinat pel CRG que abordarà la falta de coneixement sobre els microorganismes.
L'objectiu del projecte, on també participa @CREAF_ecologia, @Andorra_RI i @CNRS, es crear un 'àlbum de fotos familiar' del món invisible dels llacs pirinencs. El projecte ha començat formalment avui en un acte a Ordino, Andorra.
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🚀Full steam ahead on our collaboration with @mele_lab! Launching again a full run of 5 flow cells on the @nanopore GridION. Excited to discover new findings together🧬@CRGenomica @BSC_CNS
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Looking back on a nice lab retreat last week! 🌟 Filled with thoughtful discussions, team-building activities, and fun nature walks. Here are some highlights 📸
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Very happy to contribute to the #JBG2023 with engaging talks and posters from our lab!
@SCB_iec @BiBcn @CosmoCaixa_CAT
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Ready to start the PRBB Open Day and present our science to the public 🧬💻🪰🐝🫁🌻🌍🌷
#openPRBB @CRGenomica @the_prbb
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Great time last week presenting our work during Jornada de #Cromatina and #Epigenètica @SCB_iec ⭐️🧬
#SCBCromEpi
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@f_calvet presenting his great work on genome annotation GeneidX 🧬👨💻 #JBG2022
github.com/guigolab/geneidx
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Day 2 of #ECCB2022 featured intriguing keynote talks by Raul Rabadan and Ana Freitas! The #Applications session covered topics ranging from data modelling, to cloud infrastructure and in-memory computing. This is the place to be 💻
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Looking back on a great kick-off to #ECCB2022 by @Alfons_Valencia followed by an inspiring talk by @cesifoti on "How humans judge machines" 🖥️🧬🤖
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(9/9) MANTA is not restricted to the analysis of genotypes/phenotypes. It can be applied to any set of predictor and response variables, expanding its usage to multiple fields (Chemistry, Economics, Epidemiology, Psychology...). So you’d better add it to your statistical toolbox!
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(8/9) In the @uk_biobank cohort, using a @nextflowio pipeline for multi-trait GWAS based on MANTA, we performed the largest GWAS to date of MRI-derived volumes of hippocampal subfields. Most of the identified loci had not been previously related to the hippocampus.
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(7/9) Using our approach, we implemented a @nextflowio pipeline and performed population-biased sQTL mapping across @GTExPortal tissues. We identified thousands of genetic variants that affect alternative splicing differently depending on ethnicity, such as rs2739412 (KLK5 gene).
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(6/9) We show that MANTA yields calibrated p-values regardless of the distribution and number of traits. Our method displays large power to identify genetic associations, comparable to or even higher than parametric approaches. It is also computationally more efficient.
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(1/9) Many quantitative phenotypes are intrinsically multi-trait: size and connectivity of brain regions, levels of blood lipids, composition of the gut microbiota, abundances of AS isoforms, single-cell gene expression... These traits are often not normally distributed.
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Looking back on an insightful poster session to finish off day 1 of the @PrecisionTox General Consortium meeting in Barcelona! Kudos to our very own Giovanni, Marina and @PaoloMarangio for putting together a great poster! #precisionToxicology #DaphniaMagna #functionalgenomics
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Congratulations to our group leader @RodericGuigo for his exceptional research performance demonstrated by the production of multiple highly cited papers, and for being included among the top 1% most cited scientists in Molecular Biology and Genetics in 2020.
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Yesterday, PhD candidate Diego Garrido successfully defended his thesis "A multivariate approach to study the genetic determinants of phenotypic traits". Congratulations Diego!
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And now, our lab member @julienlag speaking about an assessment of methods for third-generation long-read transcriptome sequencing at
@SCBcat's #JBG2019
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Congratulations to our PhD student, Beatrice Borsari, runner-up winner of the best presentation award in the 2019 ENCODE Consortium Meeting! You deserve it!!!!
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Our wet lab team (@ArnanCarme @sperezlluch @Silvia_Torello) was participating in the #openPRBB talking about DNA sequencing. We hope you enjoyed!!! @the_prbb @CRGenomica
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New work from the lab! "Ten simple rules for providing optimal administrative support to research teams" Really useful! Congrats Romina Garrido et al., PLOSCompBiol @CRGenomica
Don't miss out => journals.plos.org/ploscompbi…
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@sperezlluch and Cecilia Klein were representing our lab at the 26th European Drosophila Research Conference #edrc2019
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Our researcher @natvilortejedor (@CRGenomica @fpmaragall) presenting at the #AAIC19 @alzassociation Don't miss her work: "Influence of BDNF Val66Met Polymorphism and APOEe4 on Hippocampal subfields"!
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Beatrice Borsari (@CRGenomica), PhD student of our group, presenting: "Investigating the role of RBPs and chromatin-side features in the timing of RNA processing events" at the ENCODE 2019: Research applications & Users Meetings, in Seattle (WA). @ENCODE_NIH #ENCODE2019
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Natalia Vilor-Tejedor (@natvilortejedor @CRGenomica @fpmaragall) presenting "Statistical tools for omics data analysis" at @IMIBIC, Cordoba
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Mariona Bustamante (@GuigoLab @CRGenomica @ISGLOBALorg) presented her poster on the Identification of blood cis expression quantitative trait methylations (eQTMs) in children at European Society Human Genetics conference #ESHG2019 Gothenburg
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Natàlia Vilor-Tejedor (@natvilortejedor), postdoctoral researcher from our lab (@GuigoLab) @CRGenomica and from the Neuroimaging Group at BarcelonaBeta
Brain Research Center (@fpmaragall), talking about Strategies for integrated analysis in Imaging Genetics at @CebEib19 @IBSstats
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Concluding remarks from Roderic (@GuigoLab) at the 12th ACGT Computational Genomics Workshop 2019 @CRGenomica
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The @GencodeGenes mini-consortium after 2 days of productive meetings @emblebi with our Scientific Advisory Board
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In this week's technical session, Marina gave us an overview of the latest protocols for Spatial Transcriptomics.
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Today @julienlag presented @CRGenomica's progress towards a better lincRNA annotation in human &mouse genomes to other @GencodeGenes members
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Yesterday we had a @GuigoLab technical session about version control using git, thanks @emilio491 for sharing useful tips and tricks with the rest of the lab!
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@Silvia_Torello spoke about our @GencodeGenes work at the London Calling @nanopore Conference today! #LC2019
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@sperezlluch presenting her poster on the regulation of blistered isoform usage by its natural antisense transcript bsAS at #CSRNA19 Berlin
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Montserrat Corominas, from @UniBarcelona, is currently presenting work performed in her lab, in collaboration with @GuigoLab members @RodericGuigo, Cecilia Klein and @RazielAmadorR (poster #65, "The Regulatory Landscape Underlying Epithelial Regeneration in Drosophila") #BoG19
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Managed to gather quite a few Guigó lab alumni from all over the world for Roderic's surprise 60th birthday party! Tot un èxit!
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Cava cheers to lab birthday twins @RodericGuigo (60) and @RazielAmadorR (somewhat younger)!!!
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Marina presenting FLEA-ChIP @SCBcat @iec : a simple, affordable, ultra low-input chromatin immuno-precipitation protocol developed in our lab
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