The Journal of General Physiology (JGP) publishes peer-reviewed research in physiological problems at the cellular and molecular level. Est. 1918 - @RockUPress
New York, NY
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Our November issue is here! hubs.la/Q04CTBGf0
🔬 Yamada, Karakas, and Denton (hubs.la/Q04CTBBn0) reveal how an extracellular pore motif controls inhibition of VRACs by DCPIB, providing new insights into the molecular basis of drug–channel interactions.
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(2/2) @t_stevenson95, @JSRustenhoven et al. @FMHS_UoA show that accumulation of α-synuclein at central nervous system (CNS) borders promotes TNF-mediated inflammation and impairs CNS clearance. doi.org/10.1084/jem.20251245
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Dmytro Vasylyev, Sidharth Tyagi, Stephen G. Waxman et al. @YaleMed show that Nav1.7 and Nav1.8 #sodiumchannels work cooperatively to control sensory-neuron excitability. hubs.la/Q04CTpMg0
#Biophysics #MolecularPhysiology #ComputationalBiology #Nerve #IonChannels
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Commentary: A new study by Hariharan et al. (hubs.la/Q04Cty6K0) reveals reduced function of brain capillary pericyte KATP channels in a mouse model of #Alzheimers disease. William F. Jackson discusses the questions raised by the study: hubs.la/Q04CtxLB0
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📣 #CallForPapers on #Myofilaments is now open! JGP welcomes submissions that focus on #myofilament structure, elasticity, and regulatory networks in muscle function and disease. Learn more and submit your work here 👉 hubs.la/Q04p5BBF0
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“JGP continues to champion the work after publication, helping its significance reach the broader scientific community.” — Chieko Koike @ChiekoKoike, Ritsumeikan University
Learn more about JGP: hubs.la/Q04wLJVt0
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Read Dr. Koike and colleagues’ JGP article, “A mechanism for pathological oscillations in mouse retinal ganglion cells in a model of night blindness Open Access.” hubs.la/Q04t83Z60
See commentary in Research News, “The origins of oscillations.” hubs.la/Q04t83WG0
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Research News: JGP study by Arooj Shahid, Mei Methawasin et al. (hubs.la/Q04BB4DP0) reveals sex-based differences in the contributors to diastolic stress in #cardiomyocytes from #HFpEF model mice. hubs.la/Q04BB4DP0
#CardiacMuscle
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Hariharan, Longden et al. @UMmedschool show that in a mouse model of #Alzheimers disease, capillary blood flow control fails early: endothelial Kir2.1 currents decline at 2–4 mo, followed by pericyte KATP channel impairment by 6–8 mo. hubs.la/Q04BhqDg0
#IonChannels
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📣 #CallForPapers “What’s Hot in #Myofilament Structure, Elasticity, and Regulatory Networks in Muscle Function & Disease” Submissions of all article types are welcome, incl. Research Articles, Communications, Hypotheses, Methods & Approaches, & Reviews 👉 hubs.la/Q04p5d7Z0
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“JGP’s review process is rigorous and fair, and the editors do not allow competitive pressures to override a balanced assessment of the science.” — Chieko Koike, Ritsumeikan University
Learn more about JGP: hubs.la/Q04wLJVs0
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Read Dr. Koike and colleagues’ JGP article, “A mechanism for pathological oscillations in mouse retinal ganglion cells in a model of night blindness Open Access.” hubs.la/Q04t83Z60
See commentary in Research News, “The origins of oscillations.” hubs.la/Q04t83WG0
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Jae Won Kwon, Sung Joon Kim, Young Keul Jeon et al. @SeoulNatlUni show that myofilament-associated nNOS preferentially restrains right ventricular contraction by regulating Ca²⁺-binding affinity through #troponin I phosphorylation. hubs.la/Q04z9qWN0
#CardiacMuscle
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Journal of General Physiology retweeted
知った顔だなと思ったら自分でした！！
実に素晴らしい雑誌です。
“JGP is one of the increasingly rare journals where editorial decisions remain firmly centered on scientific merit.” — Chieko Koike @ChiekoKoike, Ritsumeikan University
Learn more about JGP: hubs.la/Q04wLJF20
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📣 2026 #CallForPapers on #Myofilaments is now open! The review process will be overseen by JGP Editor Henk Granzier, with Guest Editors and subject experts Brett Colson, Jonathan Kirk, Julian Stelzer, and Jennifer Van Eyk. 👉 hubs.la/Q04p5FZX0
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“JGP is one of the increasingly rare journals where editorial decisions remain firmly centered on scientific merit.” — Chieko Koike @ChiekoKoike, Ritsumeikan University
Learn more about JGP: hubs.la/Q04wLJF20
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Read Dr. Koike and colleagues’ JGP article, “A mechanism for pathological oscillations in mouse retinal ganglion cells in a model of night blindness Open Access.” hubs.la/Q04t83Z60
See commentary in Research News, “The origins of oscillations.” hubs.la/Q04t83WG0
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Yamada, Karakas, & Denton @VUMCDiscoveries show that the prototypical LRRC8/VRAC inhibitor DCPIB stabilizes an inactivated channel state through coordinated interactions spanning extracellular, transmembrane, & N-terminal channel domains hubs.la/Q04y2TFr0
#IonChannels
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KATP channels link a cell’s metabolic state to its electrical excitability through the binding of ADP/ATP to three classes of nucleotide-binding site. Rubio et al. synthesize & characterize a fluorescent ATP derivative to probe the activity of these sites. hubs.la/Q04xSbbq0
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Heart rate is controlled, in part, by the opening and closing of the ion channel HCN4. Blecker, Bankston et al. @CUAnschutz describe the functionally relevant domains of both the channel and its ER-resident potentiator, IRAG. hubs.la/Q04x80ds0
#Biophysics #IonChannels
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