Group leader @MolHorizons @UOW studying all things DNA replication | DECRA fellow & NHMRC Investigator
Wollongong, Australia
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- Following 742
- Followers 421
- Likes 2,635
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How is the separation of two DNA strands nucleated after the initiation of chromosome replication in eukaryotes?
We were curious too...
You can read about what we found here @Nature – a sneak peak👇
nature.com/articles/s41586-0…
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🚀 Exciting opportunity! We’re looking for a Postdoc to join the Lewis & Spenkelink Lab @MolHorizons 🎓
Love structural biology, biochemistry & mitochondrial DNA replication? Come work with us!
Start: July 2025 | Location: Coastal Wollongong 🌊
Apply: uow.edu.au/about/jobs/jobs-a…
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How do mitochondria replicate their DNA? 🧬 Excited to share that our lab, based at @MolHorizons and led together with @LMSpenkelink, has been awarded an ARC Discovery Project Grant to tackle this fundamental question! 🎉 Postdoc & PhD opportunities coming soon! #Science
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RT @Yates_luke: 🚨 We are looking for a new cryoEM 🔬 facility manager @SussexUni This is fantastic opportunity to work with leading research…
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Jacob Lewis 🧬 📷 retweeted
#UOW early career researchers Dr Lei Deng, Dr Xiaoning Li, Dr @MMavilidi, and Dr Rupeng Yang each received close to $500,000 as part of the @arc_gov_au Discovery Early Career Researcher Award prestigious fellowship scheme. 🎉 #UOWResearch
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Jacob Lewis 🧬 📷 retweeted
Interested in how MALDI-2 enables @imaging_ms of metabolites at #singlecell resolution. Then check out @J_C_Mckinnon's latest paper.
@uowresearch
pubs.acs.org/doi/10.1021/jas…
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Jacob Lewis 🧬 📷 retweeted
UOW researcher Prof Martina Sanderson-Smith @DrmartinaS is among a national team of scientists shortlisted for this year’s Australian Museum Eureka Prize for their ongoing work into the clinical impact of StrepA infections in children.
@uowresearch @UOW
uow.edu.au/media/2024/uow-re…
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Jacob Lewis 🧬 📷 retweeted
I am seeking an enthusiastic postdoc to join my lab in Sydney to work on Nuclear Dynamics, DNA repair and genome stability. We offer innovative science, a competitive salary, and a supportive team.
If you are interested, please get in touch with me: nlamm-shalem@cmri.org.au
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Congratulations @CostaLabCrick
Congratulations to group leaders Snezhka Oliferenko and Alessandro Costa (@CostaLabCrick) on being elected as members of @EMBO 🥳
crick.ac.uk/news-and-reports…
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Jacob Lewis 🧬 📷 retweeted
What if we could universally recombine, insert, delete, or invert any two pieces of DNA?
In back-to-back @Nature papers, we report the discovery of bridge RNAs and 3 atomic structures of the first natural RNA-guided recombinase - a new mechanism for programmable genome design
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Jacob Lewis 🧬 📷 retweeted
Insight into Single-Molecule Imaging Techniques for the Study of Prokaryotic Genome Maintenance
A review by Lisanne Spenkelink, Stefan Mueller et al @LMSpenkelink @StefanHMue @UOW
🔓 Open access in ACS Chemical & Biomedical Imaging 👉 go.acs.org/9SX
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It’s finally out! Glad to have contributed to this mammoth effort by Sarah!
How does Mcm10 activate an origin of replication?
Find the answer in our paper published today in @NatureSMB. Congratulations to Sarah Henrikus & our fantastic lab! 🥳🎉
rdcu.be/dIdI4
Great collaboration with Marta, Allie and John from @DiffleyLab @TheCrick
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Jacob Lewis 🧬 📷 retweeted
AlphaFold3 is insane. MutS protein (green) recognizes base mismatches in DNA (gray), after which it slides off to find MutL matchmaker protein (blue), which positions and activates MutH nuclease (pink) to nick a hemimethylated GATC sequence (red) to activate removal and repair of the mismatched strand.
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Jacob Lewis 🧬 📷 retweeted
🚨 Did you know we're #hiring? 🚨
We have a fully-funded #PhD ready to start as soon as July! With a backdrop like this, world class facilities and an amazing bunch of like-minded colleagues, how could you not want to join us working on mysteries of the human genome 🧬ðŸ¦
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🚨 Join us! We're seeking a Lecturer in Cell & Molecular Bioscience at UOW. Leverage our world-class cryo-electron microscopy facility for pioneering research in structural biology. Apply now! Any questions reach out! uow.edu.au/about/jobs/jobs-a…
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Jacob Lewis 🧬 📷 retweeted
Coming down from the high of Taylor-related content with the Aus part of the Eras tour now over? I've got you covered.
Introducing:
🔺Tetrahedral encapsulin protein cages (@taylorszyszka's version)
biorxiv.org/content/10.1101/…
Encapsulins form icosahedra. How did she make pyramids?
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Jacob Lewis 🧬 📷 retweeted
It was great to bring together some of the researchers at Molecular Horizons to talk about collaboration impact and mentoring at our strategic planning day last week. We look forward to the year ahead and implementing the objectives that came out of the day @uowresearch
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Jacob Lewis 🧬 📷 retweeted
I am happy to announce that we've recently posted our new manuscript, titled: ‘Cell Cycle Regulation has Shaped Budding Yeast Replication Origin Structure and Function’ on BioRxiv (biorxiv.org/content/10.1101/…). We hope you enjoy! Tweetorial below:
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