Enzyme designer // Postdoc @ Novonesis & DTU
Copenhagen, Denmark
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Anna and Sam are X-less but they’ve done some excellent work with this project. It’s a very exciting time for enzyme designers!
New research in Science represents a notable step forward in designing enzymes from scratch.
With a new approach, researchers designed an enzyme that uses a covalent intermediate to catalyze a two-step reaction, analogous to what many proteases do when breaking apart proteins.
Learn more: scim.ag/4hU7O1H
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Kiera Sumida retweeted
BREAKING NEWS
The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.”
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Kiera Sumida retweeted
I'm sharing my story in a difficult time for Palestinians and Lebanon, where we found refuge after being exiled from Haifa. I want to honor those who suffered the most and never got to live out their dreams—my grandparents, Jido Ali and Taita Khadejeh. I hope they’re proud (1/3)
The first episode of @BakerLabPodcast is live. Meet Mohamad Abedi, who went from being a Palestinian refugee to a postdoctoral researcher. His journey proves that science can be a creative and transformative process.
Apple: podcasts.apple.com/us/podcas…
Spotify: open.spotify.com/show/32pWWp…
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Kiera Sumida retweeted
Here’s our human protein-protein interactome. We mined the SRA, devised a new distillation dataset for protein complexes, trained a new version of RF2 to screen millions of protein pairs, and identify > 18k binary interactions. biorxiv.org/content/10.1101/…
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Kiera Sumida retweeted
ML for the de novo design of serine hydrolases
Anna Lauko Samuel Pellock @KieraSumida @DaveJuergens
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Our paper using ProteinMPNN redesign for improved properties is up on JACS! Huge thanks to Reyes, @ikalvet, Sam, and many others for their work. Shout out to @JustasDauparas for developing such a groundbreaking (and versatile!) tool. @UWproteindesign
pubs.acs.org/doi/full/10.102…
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@ikalvet performed sequence redesign and limited backbone remodeling on human myoglobin to great effect. Higher yields and thermostability leading to retention of heme binding at 95C!
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Stability issues bringing you down? Try ProteinMPNN!
Our preprint describing sequence redesign of natural proteins with ProteinMPNN for improved properties is up. Check it out:
biorxiv.org/content/10.1101/…
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