VelemaLab@LabVelema

Chemical Biology laboratory at the Radboud University in the wondrous city of Nijmegen. velemalab.com

Joined November 2019
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Very excited to share our latest preprint, led by rockstar post-doc @i_borovska. Our humble attempt to begin exploring #RNA secondary structure ensembles in a living cell (biorxiv.org/content/10.1101/…) (1/n)

RNA secondary structure ensemble mapping in a living cell identifies conserved RNA regulatory...

RNA molecules can populate ensembles of alternative structural conformations, but comprehensively mapping RNA conformational landscapes within living cells presents significant challenges and has, as...

biorxiv.org
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VelemaLab retweeted
Nadja Simeth@NadjaSimeth
8 Aug 2024
Join us! We have an opening for a PhD position to bring more light into bioorganic chemistry affection 3D structures of peptides and peptidomimetics with chromoselective photochemistry! 💡🧬🧪🔬 Apply via the online portal of our university until August 20th! (link below)
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@beharrylab@BeharryL
7 Aug 2024
🚨POST DOC OPPORTUNITY🚨@BeharryAndrew @UofT is looking for a PDF specialized in small molecule synthesis and chemical biology. Photochem experience is an asset but not required. International applications are welcome! Interested? Submit a CV to Andrew.beharry@utoronto.ca ⚛️⚗️🥼
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Postdoctoral opening in my group on synthesis of modified RNA as potential therapeutics - applications welcomed
IOCB Prague
@IOCBPrague
4 Jul 2024
A fully-funded #postdoc position is open in @hocekm lab for a project focused on the chemical and enzymatic synthesis of base-modified RNA and XNA for applications in chemical biology and the development of RNA therapeutics. Learn more and apply ⤵️ uochb.cz/en/open-positions/2…
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Catechol-Siderophore Mimics Convey Nucleic Acid Therapeutics into Bacteria (Willem A. Velema and co-workers) @LabVelema #OpenAccess onlinelibrary.wiley.com/doi/…
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Mathijs in our lab shows that you can use small siderophores to transport large antisense oligos >15 their molecular weight into bacteria! Check it out: onlinelibrary.wiley.com/doi/…
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last chance to apply for PhD study in my group - check the available projects
IOCB Prague
@IOCBPrague
26 Feb 2024
Replying to @CzechAcademy
#PhDprojects @IOCBPrague 2/ #organicchemistry #medchem @hocekm lab: 🇹 Sequence-specific enzymatic synthesis of base-modified RNA: uochb.cz/en/open-positions/2… 🇹 Modified nucleotides for selection of functional nucleic acids and labelled probes for chemical biology: uochb.cz/en/open-positions/2… 🇹 New cytostatic nucleosides and nucleotides with new mechanisms of action: uochb.cz/en/open-positions/2… #chemPhD #PhDposition #chemjobs
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Fantastic opportunity!!
Danny IncaRNAto@incaRNAtolab
7 Feb 2024
Please retweet! Several PhD and Post-doc positions available in my lab to study #RNA structure ensembles in living cells! For enquiries, contact us at the address indicated on the flyer!
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narf42@narf42
8 Jan 2024
🚨🚨🚨 We are hiring! We are looking for 2⃣ PhD students who want to join us @StratinghInst for awesome research in the field of continuous #enzyme #evolution! Informal questions per DM. Click the link below to apply! #MolecularEvolution Please RT! rug.nl/about-ug/work-with-us…
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Great opportunity!!
Zhipeng Lu
@_zhipeng_lu
25 Sep 2023
We are recruiting postdocs on several directions of RNA biology: RNA modifications, interactions, structures, and their roles in splicing, development, genetic diseases, and RNA therapeutics. Please help spread the word!
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Can drug toxicity come from binding with cellular RNAs? Today we @koolchemistry report in @NatureChemistry a Reactivity-Based RNA Profiling method, uncovering drug-RNA interactions and their impact on RNA functions in cells. nature.com/articles/s41557-0…

Pervasive transcriptome interactions of protein-targeted drugs

Nature Chemistry - Now a reactivity-based RNA profiling strategy can measure the global off-target transcriptome interactions of small-molecule drugs at single-nucleotide resolution. Using this...

nature.com
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Great meeting @koolchemistry alumn and friend @zhu_ruyi in Singapore and touring his lab!
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Enjoying food, wine and great conversation at #RNA2023 @gianpierodileva @MaikeMKHansen @LabVelema
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Learn more about recent key research in this Feature Article by Willem A. Velema (@LabVelema): 'Exploring antibiotic resistance with chemical tools' #openaccess 🔓 rsc.li/41MXdhs
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What natural talent would Willem Velema like to be gifted with? @LabVelema Find out on his #IntroducingAngewandte page onlinelibrary.wiley.com/doi/…
Angewandte Chemie@angew_chem
28 Mar 2023
A Quenched Size-Expanded Nucleotide Reports Activity of the Leukemia Biomarker Terminal Deoxynucleotidyl Transferase (TdT) (Willem A. Velema et al.) @LabVelema #openaccess onlinelibrary.wiley.com/doi/…
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VelemaLab retweeted
Zhipeng Lu
@_zhipeng_lu
2 Apr 2023
The Lu lab is recruiting a new postdoc to work on RNA interactions, modifications, animal development and human diseases. zhipenglulab.org/join/
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Mathijs constructed a fluorogenic probe for the polymerase TdT, out now! onlinelibrary.wiley.com/doi/…

A Quenched Size‐Expanded Nucleotide Reports Activity of the Leukemia Biomarker Terminal Deoxynucl...

A fluorogenic probe based on size-expanded adenosine is used to monitor activity of the leukemia biomarker and therapeutic target Terminal deoxynucleotidyl Transferase (TdT). The probe can measure...

onlinelibrary.wiley.com
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Still a few days to apply for a PhD or PostDoc for Nanopore research (Sequencing, Proteomics, Enzymology) in our Group! Several position are available, please contact me for more information: rug.nl/about-ug/work-with-us… And rug.nl/about-ug/work-with-us…
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Zhipeng Lu and I wrote a perspective on RNA cross-linking. Check it out! pubs.acs.org/doi/10.1021/jac…

Chemical RNA Cross-Linking: Mechanisms, Computational Analysis, and Biological Applications

Abstract. In recent years, RNA has emerged as a multifaceted biomolecule that is involved in virtually every function of the cell and is critical for human

pubs.acs.org
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