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We identified TRAPPC8 as a brake on UFMylation via direct binding of UBA5. Loss of this brake disrupts lysosomal function and drives tau propagation. Restoration rescues this effect in vivo—revealing it as a potential therapeutic target for tauopathies.
biorxiv.org/content/10.64898…
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New! 🧪 Chueh et al. demonstrate iPSC microglia clear intraneuronal phosphorylated-a-syn aggregates in a contact dependent manner. Microglia-specific knockdown of GPNB reduced this clearance while IL-10 receptor blockage enhanced phagocytic response.
science.org/doi/full/10.1126…
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New in Nature! 🐭 Lövestam et al. injects tau filaments from the brains of AD and CBD patients into WT mice and demonstrates propagation through prion-like templated seeding that results in disease-specific pathologic phenotypes and seed specific folding.
nature.com/articles/s41586-0…
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New in Nature Methods! 🔬🧪Joly et al. profiled intact tau molecules one at a time. Across cell models and brain tissue, they found 130 forms of full-length tau and certain phosphorylation sites that tend to show up together on the same molecule. doi.org/10.1038/s41592-026-0…
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New in Nature 🧠! Hao et al., showed tauopathy mice lacking cDC1s or antigen cross-presentation have reduced brain infiltration of CD8+ T cells, glial response, and neurodegeneration; but no change in tau phosphorylation or aggregation. Read here:
nature.com/articles/s41593-0…
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New in Nature 🔬🧪
nature.com/articles/s41593-0…
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Congratulations to Dr. @naguib_sarah, postdoctoral researcher in the Gan Lab, on receiving an NIH K99 Pathway to Independence Award! 🎉
This prestigious award recognizes her research achievements and potential to become an independent investigator.
Congrats, Sarah! 🔬🧠
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🎉New in Neuron! We identified that microglia-derived soluble DLK1 links aging to hypomyelination. In mouse and human iPSC models, telomere shortening drives microglial senescence, ↑sDLK1, and impaired oligodendrocyte maturation and neuronal activity. cell.com/neuron/fulltext/S08…
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A new 2026 Neuron paper shows that tau directly activates mitochondrial RET via complex I, driving a feed-forward cycle. These findings align with our Cell 2022 and Cell 2024 studies, supporting tau–mitochondria coupling as a central driver of tauopathy. cell.com/neuron/fulltext/S08…
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Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration. cell.com/cell/fulltext/S0092…. Human iPSC 4R tauopathy model uncovers modifiers of tau propagation. cell.com/cell/fulltext/S0092….
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From @Nature : The aging human brain is more dynamic than we thought. Somatic mutations revealed marrow-derived cells in every human brain studied, sometimes forming a large share of microglia, Clonal hematopoiesis was also linked to a lower risk of AD. nature.com/articles/s41586-0…
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Read the news coverage of our new @NatureNeuro paper here: news.weill.cornell.edu/news/…
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Our new study is out today in @NatureNeuro! Stressed neurons release DNA, activating cGAS–type I interferon signaling and driving inflammation, seizures and mortality in Dravet syndrome. Blocking cGAS disrupts this immune cascade and improves outcomes. nature.com/articles/s41593-0…
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Proud of Dr. @naguib_sarah for her new co-first author paper in @MolNeuro in collaboration with
@BlurtonJonesLab
& the Paz lab. Transplanted iPSC-derived microglia in progranulin KO mice restores pathology, circuitry, & behavior pubmed.ncbi.nlm.nih.gov/4246…
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Excited to see this comprehensive review published in Cell by Dr. Holtzman @holtzman4 and colleagues, highlighting the latest advances in Alzheimer's disease and outlining key challenges and opportunities for the field. cell.com/cell/fulltext/S0092…
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