Organizing microtubules for a living? Sure. @IRBBarcelona @LudersLab.bsky.social @LudersLab@mas.to
Barcelona, Spain
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Won’t be spending time here anymore - find us where facts still matter, where the sky is blue, and where nobody claims otherwise.
@LudersLab.bsky.social
Thank you @palex_group and the the Asociación de Síndrome de Cohen España (SICOES) for the initiative.
Your donation will help us to further explore the gene defect in patient cells that causes Cohen syndrome and how it may be repaired.
@LudersLab @IRBBarcelona
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Very sad news… Joan was director when I joined @IRBBarcelona and I owe him this great opportunity. He has led us to become not only a place for excellent science, but also a warm and welcoming environment, a rare combination. Joan will be missed, but we continue in his spirit!
Amb profunda tristesa, lamentem comunicar la mort aquesta passada matinada del Dr. Joan Guinovart, fundador, exdirector, exinvestigador i professor emèrit de l’IRB Barcelona.
El Dr. Guinovart ha estat una figura clau en l’àmbit de la bioquímica, deixant una empremta inesborrable tant a nivell científic com de gestió. La seva intel.ligència, lideratge i el seu profund humanisme han estat fonamentals per a les persones que hem tingut la sort de compartir camí amb aquest home irrepetible i per al món de la recerca.
Expressem el nostre més sentit condol a la seva família, amics, companys i a tota la comunitat de l'IRB Barcelona.
Joan, la teva absència ens deixa un gran buit, però el teu llegat perdurarà per sempre.
Et recordarem sempre, capità.
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@IRBBarcelona rock band rocking the house at our holiday party!!! #irbholidayparty
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I have not found you there, so you should move like the rest of us, the sky is still blue over there:
bsky.app/profile/luderslab.b…
…you won’t look back👇🏼
‘A place of joy’: why scientists are joining the rush to Bluesky nature.com/articles/d41586-0…
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Jens Luders @LudersLab.bsky.social retweeted
Our latest work from lab member jimmy Ly! This fundamentally changed the way we see mitosis. Massive rewiring of translational control. There is something for everyone and an amazing mechanism. Check it out.
Cells make variants of thousands of proteins. These variants are not produced indiscriminately, but rather through precise regulatory mechanisms that can meet rapidly changing needs of the cell. New work from @iaincheeseman's lab in @Nature: wi.mit.edu/news/elegant-swit… @MITBiology
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Jens Luders @LudersLab.bsky.social retweeted
Everyone should read @callimcflurry’s piece on the human cost of scientific fraud by a lab member - disillusionment, wasted time, lost trust, and reputational damage - and the challenge of recovering.
Kudos to the Bloodgood lab for their openness.
thetransmitter.org/science-a…
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Smart bees
Bumblebees will pull on a string to get a reward. But do they understand why they’re doing it? elifesciences.org/articles/9…
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Here is a free access link to our latest work @LudersLab with @LlorcaLab in @Dev_Cell on the activation of the #microtubule nucleator #gTuRC:
kwnsfk27.r.eu-west-1.awstrac…
Please also check out similar work by @MikeVVieczorek lab in the same issue!
A summary is here:
Happy to share (time-limited) free access to our latest work @Dev_Cell by Fabian Zimmermann @LudersLab @IRBBarcelona and @sernarina @CNIOStopCancer @LlorcaLab:
authors.elsevier.com/a/1jpyq…
By reconstitution and #cryoEM we show how the #microtubule nucleator #gTuRC gets activated 🧵👇
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And none of this would have happened without the fantastic collaboration with @LlorcaLab @OscarLlorcaCNIO!!! 10/10
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...that #gTuRC has essential roles beyond the nucleation of #microtubules, for example as cap and stabilizer of microtubule minus ends. 9/10
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Open/future questions: while gTuRC is considered essential for #mitosis, genome-edited cells that express only gTuRC that cannot bind CM1, grow more slowly, but can still successfully complete mitosis, suggesting CM1-independent activation of gTuRC and/or... 8/10
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...that the increased conformational repertoire of activated #gTuRC promotes cooperativity with incoming ab-tubulin. gTuRC templates with improved symmetry facilitate ab-tubulin docking, which in turn further promotes template symmetry, resulting in efficient #nucleation. 7/10
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Somewhat surprisingly, CM1 binding activates #gTuRC without inducing a complete conformational switch. However, when bound to CM1, gTuRC can adopt conformations that more closely resemble #microtubule symmetry and that are not observed in the absence of CM1. Moreover... 5/10
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A CM1-binding site mutant of gTuRC is insensitive to CM1-dependent activation both in vitro and in cells. But how does CM1 activate #gTuRC? Does it involve switching gTuRC into a 'perfect template' configuration? 4/10
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We reconstituted activated gTuRC bound to the CM1 motif of the #centrosome scaffold protein CDK5RAP2, and determined its #cryoEM structure. CM1 binds to multiple sites on the outside of gTuRC, modulating lateral interactions among GCP subunits. 3/10
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