PhD student in Hollfelder lab, University of Cambridge | Enzyme engineering & microfluidics
Cambridge, England
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Biocatalysts make chemical industry more sustainable but engineering enzymes is too slow! Check out our preprint @hollfelderlab where we show how microfluidics & AI can help: We rapidly sequence-function profile an IRED in microdroplets and use AI to accelerate its engineering⚡️
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Maximilian Gantz retweeted
🚨CALL FOR HELP🚨
Want to help shape the UK Gov’s understanding of how AI is impacting bio? My colleagues in the EngBio team in @SciTechgovuk are conducting a survey to answer exactly that!
Only 15 mins to shape UK AI policy + £200 goes to Cancer Research UK/100 replies. Link👇
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So glad to see this out! By giving a strong fluorescence signal to read out NAD(P)H concentration, SAFRAN will greatly extend the range of reactivities comfortably assayable in droplets. This will make droplet microfluidics a much more versatile tool for biocatalyst engineering!
Fluorogenic, Subsingle-Turnover Monitoring of Enzymatic Reactions Involving NAD(P)H: a Generalized Platform for Directed Ultrahigh-Throughput Evolution of Biocatalysts in Microdroplets | JACS @hollfelderlab
@Cam_Biochem @Cambridge_Uni pubs.acs.org/doi/10.1021/jac…
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It was fantastic to work on this with @mattpennerKY, Jamie Klein and many other people in the @hollfelderlab!
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Maximilian Gantz retweeted
Fluorogenic, Subsingle-Turnover Monitoring of Enzymatic Reactions Involving NAD(P)H: a Generalized Platform for Directed Ultrahigh-Throughput Evolution of Biocatalysts in Microdroplets | JACS @hollfelderlab
@Cam_Biochem @Cambridge_Uni pubs.acs.org/doi/10.1021/jac…
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Maximilian Gantz retweeted
1/ Just read through the @matthewclifford AI Action Plan now.
Tl;dr: it's great but here are a few things that stood out to me as someone interested in AI for Science and sovereign compute and data capability.
A thread: 🧵
1/ Today the Prime Minister published my AI Opportunities Action Plan for the UK and committed to implement all its recommendations. A quick thread on why this is important, what we need to do now - and how you can help
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Check out our recent review where we argue that #microfluidics and #AI are a natural match to accelerate enzyme engineering in green chemistry and beyond: pubs.rsc.org/en/content/arti…
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Really enjoyed putting this together with @SimMat20, Friederike Nintzel, @pl219_Cambridge and @hollfelderlab!
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Had a fantastic week at the GRC biocatalysis in New Hampshire! Also thrilled to have been elected as a co-chair with @hairofthehogg to organise the next GRS! Excited to work with the GRC chairs @sBiosChem, Radka Snajdrova and vice chairs Dörte Rother and @ScottFrance10!
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Had a fantastic time at #NordBioII in Stockholm and it was great to share our recent progress on interfacing microfluidics with AI to inform and accelerate enzyme engineering! Thank you for the invitation & great organisation @Ch_Schnepel!
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Maximilian Gantz retweeted
Come with us about enzyme engineering with AI and ultra high throughput screening at our poster at @gembioworkshop at #ICLR2024 with
@MaxGantz_
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Check out our new paper @NatureChemistry where we use microfluidics to identify a mini enzyme from a de novo designed library giving a plausible scenario for emergence of enzymatic function at #OriginOfLife by #DirectedEvolution!
nature.com/articles/s41557-0…
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Great collaboration between @hollfelderlab at @Cambridge_Uni the Hecht lab at @Princeton and @AdrianBunzel at ETH Zürich! Massive thank you to the other co-first authors @JDSchnettlerF & Michael Wang!
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Maximilian Gantz retweeted
Amazing to see @MaxGantz_ and team using MinION in the Peruvian Amazon to study the gut microbiome of the ocelot!
A fantastic example of how portable, real-time DNA/RNA sequencing can drive impactful ecological studies.
#AnythingAnyoneAnywhere #10YearsON
After years in preparation @MaxGantz_ and I are finally back at @hojanueva in the Peruvian Amazon. Together with Dr @sjzwicker, Dylan Singer and team of resident researchers we are investigating the gut microbiome of the ocelot by @nanopore sequencing !🐅💩🧬
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The Amazon rainforest is the most biodiverse place on the planet and much of that stunning genetic diversity remains unexplored. To start profiling that diversity before it’s lost @t_n_kohler and I set up a remote genetic laboratory in the Peruvian jungle @hojanueva 👇
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The data will be publicly available and we are open for collaboration especially at the levels of gut microbiome research, plant and mammal genomics and metagenomics-based enzyme discovery.
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Thank you @hollfelderlab and the amazing team here at @hojanueva, especially @sjzwicker and Dylan Singer. We hope this lab will serve as a platform to spawn a network of local and international collaborations to profile and conserve this wonderful ecosystem.
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Biocatalysts make chemical industry more sustainable but engineering enzymes is too slow! Check out our preprint @hollfelderlab where we show how microfluidics & AI can help: We rapidly sequence-function profile an IRED in microdroplets and use AI to accelerate its engineering⚡️
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Great collaboration with twitter-less Friederike Nintzel, @SimMat20 in the @pl219_Cambridge lab, the @FG_Mutti lab and many others!
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