Nature Biotechnology
@NatureBiotech

Publishing the best of biotech science and business. Find us on Bluesky, Facebook & Instagram. Part of @SpringerNature and @NaturePortfolio.

 NY/CA/London/Berlin
nature.com/nbt
Joined June 2009
4,833 Photos and videos
Cancer immunotherapy benefits from antibody-lectin chimeras that block glyco-immune checkpoints go.nature.com/4aRDpk8 rdcu.be/ZqESYB6vavSa

Antibody-lectin chimeras for glyco-immune checkpoint blockade

Nature Biotechnology - Cancer immunotherapy benefits from antibody-lectin chimeras that block glyco-immune checkpoints.

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Decoding systemic vascular health and hypertensive disorders in pregnancy through retinal imaging and Visionary AI nature.com/articles/s41587-0…
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The eye as a biomarker: why retinal AI could reshape how trials screen and stratify pregnant patients #NBTintheNews clinicaltrialvanguard.com/ar…

The Eye as a Biomarker: Why Retinal AI Could Reshape How Trials Screen and Stratify Pregnant...

A Nature Biotechnology retinal AI model detects preeclampsia and gestational hypertension risk non-invasively, and its trial implications go far beyond…

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Genetic code expansion enables plant-directed control of bacterial activity nature.com/articles/s41587-0…
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Engineered human Argonaute 2 for targeted C-to-U RNA base editing nature.com/articles/s41587-0…
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Stem cell repair of injured monkey spinal cords restores hand function in 53% of trials go.nature.com/3LKx0ge rdcu.be/AYFYsSnnpwZa

Extensive restoration of forelimb function in primates with spinal cord injury by neural stem cell...

Nature Biotechnology - Stem cell repair of injured monkey spinal cords restores hand function in 53% of trials.

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Deep learning perturbation models can outperform baselines on calibrated metrics - @ShiftBioscience nature.com/articles/s41587-0…
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New calibration framework improves confidence in AI virtual cell models #NBTintheNews genengnews.com/topics/artifi…

New Calibration Framework Improves Confidence in AI Virtual Cell Models

Metrics such as mean squared error and control-referenced Pearson correlation are frequently miscalibrated, according to the authors.

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Flawed benchmarks hid AI success in gene perturbation prediction #NBTintheNews bioengineer.org/flawed-bench…

Flawed Benchmarks Hid AI Success in Gene Perturbation Prediction

A new calibration framework shows that common benchmarking metrics masked real perturbation-specific signal, and that deep learning models can outperform simple baselines when evaluated properly.

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Discovery and protein language model-guided design of hyperactive transposases go.nature.com/4gXLGEw
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AI-designed proteins surpass nature in genome editing #NBTintheNews via @digwatchworld dig.watch/updates/ai-designe…

AI-designed proteins surpass nature in genome editing | Digital Watch Observatory

The discovery could accelerate gene and cell therapies for cancer and rare diseases.

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Scientists use generative AI to build better proteins for editing DNA #NBTintheNews thebrighterside.news/post/sc…

Scientists use generative AI to build better proteins for editing DNA

A genome search and protein language model produced new DNA-moving proteins, including one that doubled targeted insertion in lab tests.

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In Brief: @FDA greenlights @ionispharma's #Zanvastro, the first disease-modifying drug for a rare, progressive and often fatal neurological condition known as Alexander disease nature.com/articles/s41587-0… rdcu.be/ufenZXWBDYda

FDA nod for rare neurology drug

Nature Biotechnology - FDA nod for rare neurology drug

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Five questions with Bowen Li nature.com/articles/s41587-0…

Five questions with Bowen Li

Nature Biotechnology - A true multidisciplinary scientist, Bowen Li finds that some of the most interesting questions are located precisely at the boundaries between fields.

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Each year, we highlight companies that received sizeable early-stage funding in the previous year. @bioptimus_ai is developing multimodal and multiscale AI pathology models for biomarker and drug treatment prediction nature.com/articles/s41587-0…

Editor’s pick: Bioptimus

Nature Biotechnology - Each year, Nature Biotechnology highlights companies that received sizeable early-stage funding in the previous year. Bioptimus is developing multimodal and multiscale AI...

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Nature Biotechnology retweeted
nature
@Nature
Oct 17
How much do PhD students earn? The first comprehensive overview of PhD income shows vast imbalances across much of Europe Read the full story: go.nature.com/4B8qAwD go.nature.com/4zwzdiR
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Nature Biotechnology retweeted
Ke Cheng, Ph.D.@KeChengLab
Oct 13
Many thanks to @NatureBiotech for selecting our work as the front cover. Congratulations again to @ShuoL_ and the entire team.
Nature Biotechnology
@NatureBiotech
Oct 12
The October issue is live nature.com/nbt/volumes/44/is… On the cover, engineered inhalable exosomes display a bispecific T cell activator targeting a cancer cell along with a T cell. PD1 and FZD on the exosomes block tumor-cell PD-L1 signaling and neutralize tumor-secreted Wnt, respectively go.nature.com/496Ins7 rdcu.be/avnjBsFZKzFa
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Human Cell Atlas@humancellatlas
Oct 13
Fabulous to see this editorial from @NatureBiotech, highlighting HCA achievements and technologies over the past 10 years, and the ambitious plans for the future. Watch this space! #HumanCellAtlas #Genomics
Nature Biotechnology
@NatureBiotech
Oct 12
Ten years, tens of millions of cells nature.com/articles/s41587-0…
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🎉 Wonderful Q&A with @UofT researcher Bowen Li (@BowenLi_Lab)! @NatureBiotech nature.com/articles/s41587-0… #MedX #MedTwitter #MedEd #AIinHealthcare #HealthAI #HealthTech

Five questions with Bowen Li

Nature Biotechnology - A true multidisciplinary scientist, Bowen Li finds that some of the most interesting questions are located precisely at the boundaries between fields.

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Highly multiplexed mammalian metabolic engineering with a shotgun approach - @sudpinglay @JefBoeke nature.com/articles/s41587-0…
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Shotgun genetic engineering lets mammalian cells stumble onto new metabolic pathways #NBTintheNews scienmag.com/shotgun-genetic…

Shotgun genetic engineering lets mammalian cells stumble onto new metabolic

A Nature Biotechnology commentary highlights how shotgun genetic engineering, which tests vast random combinations of genes in mammalian cells, enabled the discovery of functional new pathways for...

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T cell immunity declines with thymic atrophy, but thymic cell grafts rescue T cell function go.nature.com/3Jp6B72 rdcu.be/4C6R4B1ZJaWa

Mesenchymal thymic niche cells enable regeneration of the adult thymus and T cell immunity

Nature Biotechnology - T cell immunity declines with thymic atrophy, but thymic cell grafts rescue T cell function.

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Cross-species analysis of thymic stroma in mice and humans reveals a subset of mesenchymal cells that are capable of restoring thymic function, which suggests new strategies for thymus regeneration #NBTNV go.nature.com/4r1A8Vp rdcu.be/eOpTg

Mesenchymal cells rebuild the thymus

Nature Biotechnology - Cross-species analysis of thymic stroma in mice and humans reveals a subset of mesenchymal cells that are capable of restoring thymic function, which suggests new strategies...

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In vivo engineering of CAR natural killer cells for immunotherapy using ligand-directed lipid nanoparticles nature.com/articles/s41587-0…
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Reprogrammed NK immune cells target cancer and autoimmune disorders #NBTintheNews via @MIT news.mit.edu/2026/reprogramm…

Reprogrammed NK immune cells target cancer and autoimmune disorders

MIT engineers developed lipid nanoparticles that deliver mRNA to program natural killer (NK) cells inside the body. These CAR NK cells could be used to treat T cell cancers or autoimmune disorders...

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While mammalian delivery technologies are advancing to translation at an exceptional rate, delivery to plant tissues faces challenges, limiting their practical applications nature.com/articles/s41587-0…
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Structural variant detection across sequencing technologies nature.com/articles/s41587-0…
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