Founder, President & CEO @kymeratx - $KYMR - runner and sailing enthusiast - tweets my own

Cambridge, MA
This is why we show up to work every day: to help patients who don't have the right treatment options. This beautiful story follows a family in the rare disease community who helped change the course of a rare kidney disease. I'm honored to have played a small part in it. apple.news/A0jQ37HOHT7GqTJ_6…
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Nello Mainolfi retweeted
We’re excited to share that Kymera has been named a finalist for the 2026 @Citeline Scrip Awards! Our BroADen Phase 1b atopic dermatitis trial of KT-621, our investigational, first-in-class, oral STAT6 degrader, was shortlisted in the Clinical Advance of the Year – Early Stage Editor’s Choice category. We’re proud to see the incredible work of the Kymera team recognized alongside this year’s finalists.
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Thanks @rahulc and @Biotech2050Pod , I have done a few of these, I felt this was one of the best discussions!
🧬 From a fringe scientific bet to pioneering targeted protein degradation.@KymeraTx CEO @NelloMainolfi joins @rahulc on #Biotech2050 to discuss drug discovery, immunology, disciplined growth & building a culture that can do what’s never been done. 🎧 - on.soundcloud.com/ksNbuIbEJt…
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Nello Mainolfi retweeted
$KYMR Explore our upcoming investor events in September in our latest press release: bit.ly/4zU2R2F
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Nello Mainolfi retweeted
We’re looking forward to the #ERSCongress and #EADVCongress this month. Visit the Kymera booth and check out our poster presentations featuring KT-621, our investigational, first-in-class, oral STAT6 degrader. Hope to see you there! Learn more: bit.ly/4gs7o4O #EADV2026 #ERS2026 #RevolutionizingImmunology
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It was great to sit down with @KymeraTx co-founder @LifeSciVC and revisit our early days, from the science that brought us together to the early decisions that still shape how we are building the company today. Ten years later, I’m proud of how far we’ve come and even more focused on what lies ahead as we continue working to deliver a new generation of medicines to patients around the world. linkedin.com/pulse/earning-r…
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So proud of what the team @KymeraTx has accomplished in Q2 2026! - completed enrollment of BROADEN2, our global Ph2b study in atopic dermatitis patients of our FIC STAT6 degrader KY-621, 6 months ahead of schedule. - continued to advance enrollment of BREADTH, our global Ph2b study in type 2 asthma patients of our FIC STAT6 degrader KT-621 - advanced our FIC IRF5 degrader KT-579 through Ph1 studies - Initiated with our partner Sanofi a healthy volunteers Ph1 study of KT-485, our second generation IRAK4 degrader - made tremendous progress on our innovative preclinical pipeline! What’s ahead in Q4 2026? - first ever disclosure of pk, pd, safety of IRF5 degradation with KT-579 in humans - likely the most anticipated data set for the rest of 2026: our BROADEN2 data readout for KT-621. While these are critical milestones the team is currently focused on ph3 planning and initiation for KT-621, which has been accelerated by at least 6 months and SLE patient study planning and initiation for KT-579! Stay tuned!
Today we shared our second quarter 2026 financial results and highlighted recent company updates and upcoming milestones. Discover how we’re advancing an industry leading pipeline of oral small molecule degrader medicines in immunology with the potential to transform patients’ lives around the world: bit.ly/4z3yA12 #RevolutionizingImmunology $KYMR
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Nello Mainolfi retweeted
$KYMR Join us on August 5th for our quarterly financial results and latest company updates: bit.ly/4yMAbbd
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I’m very excited to welcome Terence to @KymeraTx. As we prepare for the global Phase 3 development of KT-621 across multiple Type 2 inflammatory diseases, Terence’s deep experience leading late-stage immunology programs and organizations will be instrumental in helping us achieve the level of patient impact we have set out to deliver at Kymera. I also want to thank Jared for the tremendous contributions he has made in helping build Kymera into the company it is today. After an extraordinary career spanning more than 40 years in academic medicine and the biotechnology industry, I wish him nothing but the very best in a well-deserved retirement.
Today, we announced the appointment of Terence Rooney, MD, as Chief Medical Officer. Terence brings deep immunology drug development experience to Kymera as we advance our oral immunology portfolio and work to expand treatment options for patients living with immuno-inflammatory diseases. Welcome to the team, Terence! Read more: bit.ly/4x0uSDq
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Looking forward to this!
This morning, our CEO, @NelloMainolfi, will join fellow biopharma leaders at the @BiotechTV U.S. Science Summit to discuss the state of innovation and how bold ideas and a shared commitment to impact can advance drug discovery and shape the future of healthcare. Follow along on @BiotechTV's channels for event highlights!
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Thanks for having me on the show!
$KYMR shares notching a record close after giving a better-than-expected timeline for its fast-tracked ezcema oral treatment trial. @KymeraTx CEO on record stock run, upbeat eczema oral treatment trial data cnbc.com/video/2026/07/07/ky…
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Excited to welcome Liz to @KymeraTx, she’s going to be a true leader of our STAT6 franchise and help us get this important medicine to patients as soon as possible!
Today, we announced the appointment of Elizabeth Laws as Senior Vice President, KT-621 Development Program Leader. Liz brings extensive experience across immunology clinical development, global franchise strategy and commercialization to Kymera as we continue advancing KT-621, our investigational, first-in-class, oral STAT6 degrader, as a potential paradigm-shifting oral therapy for multiple Type 2 inflammatory diseases. Welcome to the team, Liz! bit.ly/4p3ifog #RevolutionizingImmunology
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Looking forward to this event, thanks Brad for the invite!
𝐒𝐩𝐞𝐚𝐤𝐞𝐫 𝐀𝐧𝐧𝐨𝐮𝐧𝐜𝐞𝐦𝐞𝐧𝐭: At our upcoming summit, we will highlight science happening today that has the potential to change medicine. We're excited to welcome @KymeraTx's @NelloMainolfi, a pioneer in protein degraders, as a speaker. More: biotechtv.com/us-science-sum…
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Excited to announce today that we have completed enrollment of our global Ph2b BROADEN2 trial of KT-621 in atopic dermatitis patients. This was accomplished almost 6 months faster than the original timeline which will allow us to disclose topline data by end of this year vs the original mid2027. This is a testament to the excitement around KT-621 in the investigator and patient communities for a potential transformative oral drug in this space as well as world class execution by the @KymeraTx team!
Today, we announced the completion of enrollment in our global BROADEN2 Phase 2b trial of KT-621, our investigational, first-in-class, oral STAT6 degrader, in atopic dermatitis, nearly six months ahead of anticipated timelines. This milestone enables us to accelerate our expected topline data readout to year-end 2026 and continue advancing KT-621 as a potential oral treatment option for patients living with atopic dermatitis and other Type 2 inflammatory diseases. Read more in our press release: bit.ly/4baOiNk
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Nello Mainolfi retweeted
We’re looking forward to an impactful few days in Nashville at the Revolutionizing Atopic Dermatitis conference, where the dermatology community will come together to discuss unmet patient needs and emerging therapeutic approaches in atopic dermatitis. Stop by our exhibition table and poster presentation on KT-621, our investigational, first-in-class, oral STAT6 degrader, to learn more! #RAD2026 #RevolutionizingImmunology
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First disclosure of our pk, safety and STAT6 degradation in Japanese patients after daily oral doses of KT-621! Great data that has enabled our global Ph2b studies to include Japanese patients.
At the Japanese Dermatological Association Annual Meeting, we presented Phase 1 data in healthy Japanese adults for KT-621, our investigational, first-in-class, oral STAT6 degrader. The presentation highlights KT-621’s compelling profile and its potential to transform treatment paradigms for patients living with chronic Type 2 inflammatory conditions. Learn more in our latest press release: bit.ly/443iypp #RevolutionizingImmunology
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