New Yorker | aspiring heme/onc doc | Heme/Onc Fellow DO, MBA | (Taylor’s Version)
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A new review summarizes the pathogenesis and treatment of myeloproliferative neoplasms, highlighting the role of driver mutations, inflammation, and emerging targeted therapies that may achieve durable disease modification.
Read the Review Article “Myeloproliferative Neoplasms” by Isabelle Plo, PhD, and William Vainchenker, MD, PhD: nej.md/4wD0AWG
ALT An illustrated diagram from the Review Article "Myeloproliferative Neoplasms" that shows the main structures and functions of the myeloproliferative neoplasm driver mutations. Panel A shows a schematic representation of Janus kinase 2 (JAK2) in its inactive state on the thrombopoietin receptor (MPL) and in the active conformation induced by the MPL mutations or calreticulin (CALR) mutations. Panel B shows the mechanisms of oncogenic signaling activation. Mutant CALR binds to MPL monomers in the endoplasmic reticulum and travels through the canonical secretory pathway to the cell surface.
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Nick retweeted
Outstanding child neurology parent award goes to @DrYasminKhakoo. What a cool story, and well done, Aliya!
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It’s dedicated time, which means i’ll consistently be grasping at any type of positive reinforcement with phrases like “Well if it was just the first 20 questions I would’ve gotten 20% higher!” and “This question doesn’t count since less than 50% got it correct.”
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imagine callling “cowboy like me” a WEAK SPOT on evermore 🥱😮💨
📰| @EntInsider on @TaylorSwift13's "evermore" chances of winning AOTY
"It contains more weak spots (Cowboy Like Me, Long Story Short, Closure). Despite the genius of 'Evermore,' a back-to-back victory for Swift would feel too partisan."
It’s happening again. I’m parked outside Starbucks, but I haven’t gone inside to study yet because all of Pure Heroine by Lorde has to play before I can take on any form of studying.
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That I’m finishing up my third year and already stressing/anxious knowing that the next round of match will be for my class is a pretty decent reflection of the current state of medical education 🙃
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One thing everyone should know about me is I can find something wrong with any EKG/image. Is it completely made up? Absolutely. But I found it nonetheless.
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Alexa just started playing “right where you left me” completely unprompted. How can I expected to live, laugh, love (or god forbid do school work) under these conditions?
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day 258 of third year, morale is low, havent anki’ed in months, haven’t activated my uworld subscription, 2 months out from STEP 2. send help (or ramen noodles)
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I have to give a presentation for my ob/gyn rotation and i couldn’t help but pick a topic related to coagulopathy and DIC bc how do I pass up on that opportunity?
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just worked a 24hr call. At the end of my shift I had to walk pretty far to my car, realized I lost my keys and had to retrace my steps, ultimately ordered an uber home, and had to get my car later on with my spare key. But God forbid students got free parking in the hospital lot
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In the span of a week I’ve seen a migrant mom-to-be become overwhelmed with joy at the sound of her baby’s heart after weeks of turmoil and no prenatal care and another mom experience DIC as her baby needed ventilation for meconium aspiration. Life is so delicate.
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Before this, I would always reply to the question “What kind of specialty are you interested in” with “[Random specialty of interest at the time]…or maybe medicine and then heme/onc”. I said this because I had preconceived ideas about what it meant to practice in each specialty.
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