Quantitative cell biology using computer vision and deep learning tools. @Altoslabs @institutcurie. Alumni @HFSP LTF @Cambridge_Uni@JNCASR

Paris
Can be bought by a big pharma or licensed with big pharma. It could also be a therapy for age related complications as GLP-1 like drugs have some success in very recent weeks. Very interested to see how this shapes up. PT from Oppenheimer is in the range of 90$.
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Inspired by our scheduled @Space_Station link up with the Crown Princess of Sweden, I set my camera lens on my mother’s home country (I have dual citizenship with Sweden!). With the inclination of the ISS orbit, we never pass directly over Scandinavia, but I was lucky enough to catch some aurora dancing in that neighborhood, just a few days before our call. Heja Sverige! The timelapse shows city night lights but settings optimized for aurora, air glow, stars. :06 Norway appears at right edge of screen :10 Sweden appears at right edge of screen :19 Sweden in center of screen :28 Moscow appears on right of screen :37 Moscow in center of screen In the first image, you can see part of each of the Scandinavian countries – Sweden is in the center of the image (looks like some clouds over Southern Sweden, so lights look a bit blurry there), the air glow of the atmosphere at night, and the aurora (and the edge of an ISS solar array). In the second image, you can see parts of Norway and Sweden (again a bit blurry in Southern Sweden due to clouds). The large bright spot in lower right area of image is Stockholm. Both photos were taken on March 11, and the timelapse taken on March 13.
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🚨 UNITED PASSENGER CATCHES INSANE NASA ROCKET LAUNCH FROM PLANE WINDOW — FLIGHT ATTENDANT LOSES IT MID-AIR A United flight just turned into a front-row seat to history. A woman captures the exact moment NASA’s Artemis II rocket launches… straight from her window at 30,000 feet. And then you hear the flight attendant: “15 years of flying… I’ve been praying to see something like this.” • Rocket blasting through the clouds • Crew calling it a “once in a lifetime” moment He said he flew to Florida multiple times just to see a launch… Canceled. Every time. And then this happens midair. What are the chances you randomly look out your window… and see history taking off?
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1/11 We explored how cells adhere to supported lipid bilayers (SLBs) using Invasin, a high-affinity integrin ligand. Surprisingly, cells spread and form mature integrin adhesions on fluid SLBs, revealing novel microtubules-driven mechanotransduction! nature.com/articles/s41467-0…
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I'm excited to share the new preprint from @KevinChalut and @VallierLab presenting my PhD work!
Mechanical signalling through collagen I regulates cholangiocyte specification and tubulogenesis during liver development biorxiv.org/cgi/content/shor… #biorxiv_devbio
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One of the reasons why it is so difficult to maintain weight loss is because adipose issue retains an epigenetic memory of obesity after weight loss. nature.com/articles/s41586-0…
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An exciting topic and a great line up of speakers - come join us in Ascona to think abouth living materials and their emergent properties. @Aumeier_Lab @LabBarral @MichaelsLabETH Matthieu Piel @grace05868946 and bml.ethz.ch/
Sign up now for Hybrid EMBO Workshop on CELLULAR MATTERS: A deeper look into the complex cytoplasm, 18 – 22 May 2025 in Ascona, Switzerland ✍️ Abstract submission & registration deadline: 31 January 2025 🔗 meetings.embo.org/event/25-c… #EMBOcellularmatters
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Excited to share our latest work on an image analysis paradigm that combines cell state and morphology analyses of patient biopsies at single cell resolution to uncover clinically relevant head-and-neck #cancer phenotypes! @CellCellPress cell.com/cell/fulltext/S0092… tweetorial👇
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Excited to share my PhD work with @SchuhLab @mpi_nat on #aging and #fertility out now in @CurrentBiology!🥳 Women are born wilh millions of #eggs but left with a few by the time they are in their mid-30s. #DNADamage largely drives this loss. But why can't this damage just be repaired? 🥚🧬💥 We show why aged oocytes accumulate more DNA damage and also discover a network of DNA repair compartments! Read more below 👇
Women lose >90% of their #eggs by their mid-30s, with persistent #DNADamage driving this loss. But why isn’t this damage repaired? Our new work in @CurrentBiology, led by @ninadini_sharma, reveals the causes of high DNA damage in aged oocytes.🧬💥 bit.ly/48e35Ee (1/13)
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Cells maintain narrow #cellsize distributions, but also adapt size in changing conditions. We found that regulators with redundant roles in steady state have specific functions in size adaptation upon a nutrient shift. biorxiv.org/cgi/content/shor… @YagyaChadha @frank_pado @robert_ife
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7 years ago, I met a junior fellow named @JD_Buenrostro who blew me away with a vision of futuristic genomic technologies Today, we (@ajaylabade31, @carolinecomenho) are excited to share our first steps into that future: Expansion in situ genome sequencing 1/
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Wanna save $$$ while doing cell transfections. Transfection efficiency extremely low? Use this nature.com/articles/s44286-0…
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Squid&Octopi in latest @naturemethods piece “Bioimaging for all”. Without getting 🔬in hands of brilliant people in the world - we can’t democratize science. Excited to join this mission, reach out to us at @cephlainc where we are building a new vision for robotic microscopy.
In this month's Technology Feature, @CarolineSeydel reports on the approaches that members of the global bioimaging community are taking to promote more equitable access to microscopy instrumentation and expertise. nature.com/articles/s41592-0…
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Let me introduce: InstanSeg 🦠🔬💻👩‍🔬 This *would* have been a short thread about Thibaut Goldsborough’s PhD work… but he solved too many problems. Now it's a long thread about 2 preprints, a whole new approach to cell segmentation & #opensource software to make it easy to use
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Inverse blebs in mouse blastocyst now peer-reviewed @NatureCellBio with @MSchliffka and @argo_mu! nature.com/articles/s41556-0… Check out the excellent tweetorial from @MSchliffka and celebrate with this latrunculin-treated embryo that is inverse blebbing like there is no tomorrow!
🚨New preprint from the Maître lab🚨 Inverse blebs operate as hydraulic pumps during mouse blastocyst formation Check out this part of my PhD in the lab of @maitrejl in collaboration with @diane_pelzer, Julien Dumortier and @argo_mu 🧵[1/7] biorxiv.org/content/10.1101/…
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Now Online Mechanisms of mechanotransduction and physiological roles of PIEZO channels dlvr.it/TD1r8m
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