immigrant, scientist, enophile, husband, dad, professor, molecular imaging at Massachusetts General Hospital and Harvard Medical School
Based in United States
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Great opportunities opening up here!
The Gordon center started the new year with a new biological emphasis under new leadership: @MatthiasNahrend is our new director. Umar Mahmood will lead a technology-focussed sibling, the Center for Nuclear Medicine & Theranostic Sciences.
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🇺🇦Peter Caravan🇺🇦 retweeted
Excited to share that our group received another R01! A postdoc opportunity is available to develop new diagnostic and therapeutic approaches for liver fibrosis. Join us! chenlab.ucsf.edu bit.ly/3tLqc9u
#livertwitter #ScienceJobs #PhD #postdocjobs #postdocposition
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Noninvasive Quantification of Radiation-Induced Lung Injury using a Ta... sciencedirect.com/science/ar…. Great collaboration with Eric Abston and @MGHSurgery on using #MolecularImaging for early detection of radiation induced #fibrosis and monitoring treatment response
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Returning from a great #RSNA2023 and treated to this amazing moonrise while crossing the NY - Massachusetts border.
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💯 come to Orleans next June for #MolecularMR, #HyperpolarizedMR, #CEST, #contrastAgents, #Multimodal, imaging metabolism and drug action
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Despite all that Gd, there were no histological signs of kidney damage. Would be worth testing if this is true in older rats or those with prior kidney injury. End
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3. At 7-8 weeks after dosing the gadolinium retained in the rat kidneys was intact chelate. This was true of all 4 compounds tested including the linear chelate gadobenate. 5/6
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2. Not all macrocyclic GBCAs are retained equally. In rats, gadoteridol was more efficiently eliminated than gadoterate and gadobutrol. Much more gadobutrol remained in the rat kidneys. Is the same true in humans? #gadolinium 4/6
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To put this in perspective the amount of Gd that can be “invisible” in the kidney by T1 weighted MRI is about the same concentration present in blood at venous phase imaging. 3/6
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Gd is “invisible” to MRI because it is sequestered in a cellular compartment where intracompartmental water exchange is slow. It can be detected by susceptibility based methods like T2* mapping but still not sensitive to about 100 micromolar. 2/6
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This paper from @Mariane_LeFur had 3 provocative findings. 1. Gadolinium retained in kidneys is invisible to T1w MRI until it is present at high 100s of micromolar. Gd is retained in kidneys at several orders of magnitude more than in brain. #Kidney 1/6
Following administration of four different gadolinium contrast agents to healthy rats, mass spectrometry showed the highest concentration in the kidney cortex at day 17. @PeterCaravan @Mariane_LeFur @MGHMartinos @MGH_RI @i3MGH bit.ly/3FsC8ze
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Dr Hua Ma’s latest on imaging aldehydes in chronic #liver #lung #kidney #fibrosis @MGH_RI @MGHMartinos @i3MGH
Tailored Chemical Reactivity Probes for Systemic Imaging of Aldehydes in Fibroproliferative Diseases | Journal of the American Chemical Society @PeterCaravan @MGHCSB #Aldehyde #Imaging #Fibroproliferative #Disease @NYTScience @sciam @BostonGlobe
@MGH_RI pubs.acs.org/doi/10.1021/jac…
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🇺🇦Peter Caravan🇺🇦 retweeted
We're thrilled to present our latest work on #ovariancancer detection through the analysis of #extracellularvesicles . We delved into the fallopian tube to identify early lesions. @MGHCSB @MGH_RI doi.org/10.1002/advs.2023019…
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New from @VeronicaClavij8 @sojoodi_mozhdeh and Eric Gale: Molecular Magnetic Resonance Imaging of Liver Inflammation Using an Ox... sciencedirect.com/science/ar…. #liver #NAFLD #DILI @MGHMartinos @MGH_RI @MghNafld
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Nice work from Phil and Iris and a great collaboration with Bryan Fuchs, Bob Colvin @MGHKidneys and @pfizer colleagues to image fibrotic disease activity in the kidneys
In most CKDs, lysyl oxidase oxidation of collagen forms allysine side chains, which then form stable crosslinks. This study shows MRI using Gd-OA is potentially a valuable tool for detecting and staging renal fibrogenesis bit.ly/JASN0148
@PeterCaravan @i3MGH
ALT Gd-OA detects fibrogenesis in the NTN mouse model.
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