Praful Ravi@PrafulRavi1

Genitourinary Medical Oncologist @DanaFarber_GU. Views my own

Joined June 2022
11 Photos and videos
Evaluating the impact of #RLT on clonal hematopoiesis #CHIP: our experience with #LuPSMA published in @JournalofNucMed @SNM_MI jnm.snmjournals.org/content/… @DanaFarber_GU @adamssperling @Lachelle_Dawn @HJacene @PCF_Science @urotoday 1/3

Clinical Impact and Dynamics of Clonal Hematopoiesis with 177Lu-PSMA-617 Therapy in Advanced...

The prevalence, clinical impact, and clonal dynamics of clonal hematopoiesis (CH) in patients receiving 177Lu-PSMA-617 (LuPSMA) for metastatic castration-resistant prostate cancer (mCRPC) are...

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Key points: 1) Overall CH prevalence was 66% in this post-taxane population treated with SoC LuPSMA (mostly TET2, PPM1D, DNMT3A) 2) No impact of CH on LuPSMA efficacy but some signal of greater marrow toxicity during therapy in CH+ pts 2/3
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3) Emergence of new CH clones or expansion of existing CH clones (mostly PPM1D and TP53) seen in most patients treated with LuPSMA (lesser so in comparator cohort of taxane and Ra223 treated pts) *⃣ Latter has important implications as we move LuPSMA earlier in disease 3/3
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Praful Ravi retweeted
The BMJ
@bmj_latest
Jul 9
Clinical Review: Advances in systemic therapies for advanced prostate cancer bmj.com/content/394/bmj-2025…
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Praful Ravi retweeted
OncLive.com
@OncLive
Jul 8
WATCH: @PrafulRavi1 of @DanaFarber_GU discusses data from the phase 4 PSMAtrack trial in mHSPC. #oncology #medtwitter #prostatecancer #pcsm hubs.li/Q04n-F1g0

Dr Ravi on Quantitative Results From PSMAtrack in mHSPC | OncLive

Praful Ravi, MB, BChir, MRCP, discusses data from the phase 4 PSMAtrack trial in mHSPC.

onclive.com
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Praful Ravi retweeted
UroToday.com
@urotoday
Jun 8
#Radiopharmaceuticals in #ProstateCancer Part 1: Current landscape and unmet needs. @boothe_dustin @Utah_Cancer and @PrafulRavi1 @DanaFarber_GU join @DrPhilKantoff @ConvergentRx discussing the clinical positioning of lutetium-177 PSMA in metastatic #CRPC, working through patient selection, sequencing, and progression after Pluvicto. #WatchNow on UroToday > bit.ly/3PBm3Qn
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Praful Ravi retweeted
UroToday.com
@urotoday
May 29
Quantitative results from #PSMAtrack: a prospective study evaluating change in PSMA-PET during initial systemic therapy for #mHSPC. Upcoming poster presentation from @PrafulRavi1 @DanaFarber. #ASCO26 written coverage by @chavarriagaj @PSH_Urology > bit.ly/49sLdrc @ASCO
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Praful Ravi retweeted
Michael Hofman
@DrMHofman
May 26
Theranostics is HOT at @ASCO #ASCO26 - and we are bringing the heat straight to #SNMMI26! 🔥🎥 Attending the @SNM_MI Annual Meeting in Los Angeles but majorly FOMO-ing over the clinical trial updates happening simultaneously at ASCO in Chicago? We’ve got you covered. Join Prof. @HJacene, incoming SNMMI President, and myself for a special, live cross-continental broadcast straight from the SNMMI floor to Chicago! 📅 Date: Monday, June 1 ⏰ Time: 4:45 PM 📍 Location: Room 515A (SNMMI, Los Angeles) Get the latest, breaking science and trial data presented by featured experts @PrafulRavi1, Dr. Dan Childs, and Dr. Timothy Yap. You don’t have to choose between the two biggest meetings of the summer. See you there!
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UroToday.com
@urotoday
May 12
#Radiopharmaceuticals in #ProstateCancer Part 1: Current landscape and unmet needs. @boothe_dustin @Utah_Cancer and @PrafulRavi1 @DanaFarber_GU join @DrPhilKantoff @ConvergentRx discussing the clinical positioning of lutetium-177 PSMA in metastatic #CRPC, working through patient selection, sequencing, and progression after Pluvicto. #WatchNow on UroToday > bit.ly/3PBm3Qn
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What are the outcomes of #LuPSMA in #octagenarians with advanced prostate cancer? Our collaborative experience with @DanaFarber_GU @MayoClinic @VUMChealth led by Daniel Sentana and Avina Rami, published in @JCOOP_ASCO: ascopubs.org/doi/10.1200/OP-…

Efficacy and Safety of 177Lu-PSMA-617 in Elderly Patients With Metastatic Castration-Resistant...

PURPOSE177Lu-PSMA-617 (LuPSMA) is an approved prostate-specific membrane antigen (PSMA)–targeted radiopharmaceutical therapy for men with metastatic castration-resistant prostate cancer (mCRPC)....

ascopubs.org
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Pts >80 are under-represented in key trials with #LuPSMA. Key points: +57% PSA50, median PFS 7m, median OS 14m (comparable to #VISION trial) +Safety similar to VISION, BUT: -40% pts admitted during therapy (though minority were treatment-related) -1 treatment-related death
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Overall, this demonstrates good outcomes with #LuPSMA in well-selected octagenarians with mCRPC - and highlight potential role for #oncogeriatric care and frailty assessment to help reduce need for hospital admissions/unplanned care utilization @PCF_Science @urotoday
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Praful Ravi retweeted
Jabra Zarka@JZarkaMD
Apr 19
Excited to share our new study: “LuRa” What happens after Lu-PSMA in mCRPC? We evaluated Radium-223 after [177Lu]Lu-PSMA-617 in heavily pretreated mCRPC patients. sciencedirect.com/science/ar…
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How are patients receiving #LuPSMA monitored during routine practice? Read our manuscript, led by @harvardmed student Narmeen Rashid, published in Clin Gen Cancers: @DanaFarber_GU @PCF_Science @urotoday @HJacene sciencedirect.com/science/ar…
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Key points: 1. Significant heterogeneity in use of scans, with 20% getting no scans during therapy. 2. PSA responses (if seen) almost always occur within first 2 cycles. 3. Radiographic progression seen in ~10% of patients without PSA progression --> restaging scans are important
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Praful Ravi retweeted
JNM@JournalofNucMed
Feb 3
Learn more about LASER: A phase 2 trial of ¹⁷⁷Lu-PSMA-617 as systemic therapy for renal cell carcinoma. ow.ly/84Hv50Y0Pz3 #NuclearMedicine #RPTherapy #RenalCellCarcinoma @PrafulRavi1 @HJacene @DrChoueiri
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Praful Ravi retweeted
Dana-Farber News
@DanaFarberNews
Jan 21
Radioligand therapy in kidney cancer: Read more about the phase 2 LASER trial, evaluating the safety and preliminary efficacy of Lu-PSMA-617 as systemic therapy for PSMA-positive clear cell renal cell carcinoma. The protocol paper published in @JournalofNucMed. @DanaFarber @PrafulRavi1 @HJacene @KrauthammerShir ➡️ bit.ly/4qz1dOY
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Does #LuPSMA #Pluvicto have activity in PSMA+ve ccRCC? Protocol of our ongoing IIT published in @JournalofNucMed @HJacene @DrChoueiri @DanaFarber_GU @DanaFarberNews jnm.snmjournals.org/content/…

LASER: A Phase 2 Trial of 177Lu-PSMA-617 as Systemic Therapy for RCC

Renal cell carcinoma is one of the most common malignancies in the United States, with clear cell renal cell carcinoma (ccRCC) comprising approximately 70% of all cases. ccRCC remains therapeutically...

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Praful Ravi retweeted
GU Oncology Now@GUOncologyNow
Jan 13
⭐ An expert panel discussion featuring @DrScottTagawa, @DrPinkalDesai, @prafulravi1, and @ResearchWyatt focused on clonal hematopoiesis in the field of prostate cancer, exploring its prevalence and clinical implications. Watch part 1 here 👉 buff.ly/XXqtzVa @DanaFarberNews @DanaFarber_GU @WeillCornell
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Our latest #ICECAP work on role of docetaxel with ADT and RT in high-risk prostate cancer, published now in @EurUrolOncol: sciencedirect.com/science/ar… @DanaFarber_GU @DanaFarberNews @ChrisSweens1 @PCFnews
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Take-aways: 1) No benefit seen overall. 2) Possible hint of more benefit in those with very high-risk disease (2-3 RFs, N1). 3) Biomarkers needed (? Decipher, Artera, PTEN loss) to identify who within very high-risk population may stand to be benefit with adding docetaxel
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