Today we're launching the Alzheimer's Translation Challenge, a global AI competition to discover new therapeutic hypotheses for Alzheimer's disease.
At its core is a new 150M cell atlas of neurons, astrocytes, and microglia across different genetic backgrounds under combinatorial perturbations, with multi-modal readouts.
The data will be made available through the AD workbench, Hugging Face and Prima Mente's modeling platform.
The challenge is led by
@PrimaMente and
@AlzData in collaboration with
@nvidia,
@huggingface,
@nebiusai, Talisman Therapeutics,
@UltimaGenomics,
@cellanome,
@PrimeIntellect,
@GoodfireAI, and
@boltz_bio.
In 1906, Alois Alzheimer described a new disease of the brain. After 120 years of progress, we still don't fully understand what drives this disease. We want to change that.
Participants will use the dataset to build AI models, assessed through a series of evals from general benchmarks to more complex tasks.
Top teams will be shortlisted, and their experimental hypotheses tested in Prima Mente's wet lab. Teams win when their hypotheses demonstrate the predicted molecular and functional effect.