Pleased to share our chemo+regorafenib+nivolumab study in @ScienceTM. CCR8+Tregs decreased during treatment but rebounded at progression, along with TREM2+macrophages. Targeting either with antibodies suppressed tumor growth in resistant mouse models. science.org/doi/10.1126/scit…

Altered gut microbiome 🦠 in autism is not uniform — it varies with clinical severity and appears more closely linked to sensory atypicalities 👂👁️👅 than to other symptom domains. Our new paper in @NatureComms: nature.com/articles/s41467-0… @CUHKMedicine @PCICuhk #Microbiome #Autism

Does Physician sex impact on clinical outcomes in close to 1 million patients with an acute medical hospitalisation? Our @JAMANetworkOpen publication led by @propelresearch @JonZipursky @WallisCJD and colleagues suggests that pts cared for by female physicians experienced lower 30-day mortality and readmissions compared with those treated by male physicians. link to paper: jamanetwork.com/journals/jam…

🧬 Early-onset colorectal cancer: a distinct tumor ecosystem? • 🌐 Stromal enrichment: Younger MSS tumors exhibit ↑ stromal/epithelial ratio, validated in 712 tumors. • 🔀 EMT signaling: ↑ inferred FN1, GDF, ACTIVIN & SPP1 interactions suggest enhanced tumor–stroma crosstalk. • 🧬 Transcriptional rewiring: ↑ lncRNA expression, including poorly characterized transcripts, in younger MSS tumors. • 🔬 Genomic landscape: CNA patterns largely conserved across ages, with a trend toward greater intratumoral heterogeneity (P=0.056). • 🎯 Therapeutic opportunities: Stromal remodeling & EMT-associated signaling emerge as potential vulnerabilities. 📄 doi.org/10.1038/s41591-026-0…

Voting for the @ASCO Election is now open 🗳️. I am honored to be running as one of the candidates for the #NominatingCommittee. Visit asco.org/election to learn more about the candidates and place your vote! @CUHKMedicine @apoddc @APCLC_2023 @ctosociety @IASLC @LungPolicy @CUHKofficial

🌏 The APAGE Emerging Leaders Committee shares its latest publication in @NatRevGastroHep, highlighting the need for stronger mentorship, research training, and collaboration to develop Asia’s next generation of GI research leaders 🌏 📖 doi.org/10.1038/s41575-026-0…

Honored to be a reviewer for @JGHofficial ! #gastroenterology #hepatology #endoscopy #GIoncology

Nice presentations and discussion on the management of BRAF mutant metastatic colorectal cancer organized by the Asia Gastrointestinal Oncology Research Group #AGIORG #GIoncology #CRC @iaintan_mdphd @BrigetteMa2

【Global Distinction in Endoscopy】We are thrilled to announce that our Dean, Professor Philip CHIU, has been nominated as President-Elect of the @WorldEndoOrg for 2026–2028! He will officially assume the presidency from 2028 to 2030.

Happy to share our latest publication on global productivity losses due to gastrointestinal cancer mortality has been accepted in @AmJGastro Main findings: - Estimated global productivity loss totaled $177.81 billion USD - Paid labor accounted for $102.79 billion USD (57.81%) - Unpaid work contributed $75.02 billion USD (42.19%) - East Asia has the largest share of losses globally ($67.62 billion USD) journals.lww.com/ajg/abstrac…

Had the pleasure to chair tonight’s dinner symposium on nutritional oncology and precision nutrition in malignancies. Learnt a lot from our multidisciplinary experts: Dr Patricia Poon (clinical oncology) and Dr Terry Ting (dietitian). #nutrition #HKSDO

Happy to share our latest open-label pilot study that demonstrated the feasibility of fecal microbiota transplantation for modulating mucosal adherent-invasive E. coli colonization in Crohn’s now out in @NatureComms #FMT @CUHKMedicine nature.com/articles/s41467-0…

Look who’s in town! Always a pleasure to chat with my cancer genetics mentor #JoanneNgeow , especially when it’s over dim sum!

Had the pleasure to attend the #UICC world cancer congress 2026 reception #oncology #HKSDO

Ending the day is Prof Yoshino sharing his insights on early stage dMMR / MSI-H colorectal cancer #HKSDO @CUHKMedicine #digestiveoncology

Dr Chiang on the comprehensive genomic and transcriptomic profiling in gastrointestinal cancers #HKSDO @CUHKMedicine #digestiveoncology

Last but not least we are starting the colorectal cancer session where we are privileged to have Prof Karapetis sharing his expert insights on the latest updates in the management of metastatic #CRC @myESMO #HKSDO @CUHKMedicine #digestiveoncology

Prof @FlorianLordick sharing the journey of claudin 18.2 targeted therapy development, from Germany to globally #HKSDO #digestiveoncology @CUHKMedicine @myESMO

Our honour to have Prof Oh in Hong Kong to share her thoughts on the exciting advances in gastric cancer management #HKSDO @CUHKMedicine #digestiveoncology