Stanford University medical oncologist and cancer scientist, and Director of the Stanford Cancer Institute. Follows and retweets are not endorsements.
Stanford, CA
- Tweets 1,838
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SCI member @BianxiaoC & others develop GTACs, bispecific antibodies that trigger GPCR internalization and degradation, potently blocking receptor signaling. This strategy could expand therapeutic options for cancer, viral infections and immune diseases. brnw.ch/21x6weX
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SCI member @GarryPNolan & others map cellular states across 54 #neuroblastoma tumors, uncovering ADRN and MES tumor cells. Crucially, high MES gene expression predicts worse survival, independent of clinical risk factors. brnw.ch/21x6p9L
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SCI members found that urine cfRNA can noninvasively reveal #BladderCancer, track residual disease, and uncover immune signatures that predict response to BCG versus chemotherapy, potentially enabling more personalized treatment. brnw.ch/21x6eRd @AshAlizadeh @liaojoe1
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A new ENCODE resource maps 92M+ enhancer-gene interactions across human tissues and cell types, revealing how enhancers regulate genes and disease-linked variants. SCI members Michael Bassik, William Greenleaf & others advance gene regulation. brnw.ch/21x6bb7
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SCI member Mirabela Rusu & others developed MUSegNet, an AI tool that automatically detects clinically significant prostate cancer on micro-ultrasound. It outperformed baseline models and expert readers, with potential to improve biopsy targeting and reduce variability.
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SCI member @michelle_monje and team found that levetiracetam, an anti-seizure drug, disrupts GABAergic neuron-to-glioma synapses in #DMG #DIPG, slowing tumor growth and extending survival in both mouse models and retrospective patient data. brnw.ch/21x61gb
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Protein location shapes protein function. A new review highlights how multilocalization enables multifunctionality, while mislocalization contributes to disease. SCI member Emma @Prof_Lundberg & others explore the future of spatial biology. brnw.ch/21x5Uo1
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It was a pleasure to welcome the next generation of cancer researchers to Stanford today for the Comprehensive Cancer Research Training Program. Seeing the talent and curiosity of these emerging scientists gives me great optimism for the future of cancer research. #CancerResearch
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SCI member Ruijiang Li & others developed ELF, an ensemble of five pathology foundation models that improves #CancerDiagnosis, biomarker detection and treatment response prediction across multiple cancers. brnw.ch/21x5FY1
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SCI member @DrBetofMDPhD and others show that combining lymphodepleting chemotherapy with dual immune checkpoint blockade enhances clonal expansion of effector CD8+ TILs, delays tumor growth and improves survival. brnw.ch/21x5nZO
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SCI researchers developed LipoLoad, a self-assembling bacterial nanocarrier for Rose Bengal. It reduced drug clumping, provided sustained release, and improved cancer cell killing in lab studies, showing promise for simpler drug delivery. brnw.ch/21x5kc8 #Nanomedicine
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SCI member Jim Ford & colleagues found that while most oncologists are aware of germline #PharmacoGenomic testing, challenges remain. Addressing barriers around guidelines, utility, and implementation may help expand PGx-guided cancer care. brnw.ch/21x5e7X
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SCI member Kara Davis & others review how lineage switch drives aggressive acute #leukemia relapse, especially under pressure from targeted immunotherapies. Researchers offer guidance for diagnosis, monitoring, and future treatment strategies. brnw.ch/21x5asj
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SCI members Bendall_Lab, @MikeAngeloLab, & others show how low oxygen drives #glioma progression by suppressing anti-tumor immune responses, identifying new therapeutic targets for aggressive #BrainTumors. brnw.ch/21x54ZT
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SCI leader @HwakeleeMD & others review how personalized perioperative treatment could improve outcomes for early-stage #LungCancer by using biomarkers, #ctDNA, imaging, and pathologic response to tailor therapy and avoid overtreatment. brnw.ch/21x4ZIQ
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SCI member @AttardiLaura & others found that CDKN2A/ARF inactivation reshapes the #PancreaticCancer (PDAC) tumor microenvironment independent of #p53, promoting aggressive, treatment-resistant disease and revealing a promising therapeutic vulnerability.brnw.ch/21x4Siz
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SCI members identified cell-surface proteins that influence how vulnerable cancer cells are to NK cell killing, uncovering potential new targets for improving NK cell-based #CancerImmunotherapies. brnw.ch/21x4OIm
@JohnSunwooMD
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SCI leader @VivekSubbiah & others report that the OncoMimic peptide #immunotherapy EO2401, combined with nivolumab, broadened shared pre-existing T cell clusters in #AdrenalCancer, supporting its potential to enhance anti-tumor immune responses. brnw.ch/21x4HMO
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Global GLOW summit highlights confusion over NLPHL, NLPBL naming. SCI member Richard Hoppe & others joined experts and patients to discuss unifying the name, since inconsistent terms make it harder for patients to find info and understand their diagnosis. brnw.ch/21x4EeL
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SCI leader Crystal Mackall & others developed AIR, a molecular switch that helps #CARTcells self-regulate during activation, reducing exhaustion, boosting tumor killing, and enabling safer, more effective cell therapies. brnw.ch/21x4wH9
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