So thrilled to receive this grant, which allows me to push my #glycotime projects forward! Rolling up my sleeves and getting to work – there is still so much to be uncovered. Huge shout-out 🙏 to my brilliant & kind reviewers, wherever you are, and to @FWF_at for funding! ♦️
Stefan Mereiter, postdoc and member of the @penningerlab, was awarded the ESPRIT grant for the next three years. In this time, he will continue his research on glycosylation interference in breast cancer. We wish him success. @FWF_at@SMereiter#CancerResearch
🚨 Our newest manuscript is out in Nature Communications:
Hypersialylation in breast cancer immunoregulation: uncovering novel mechanisms and highlighting major therapeutic potential.
+6 years in the making.
Dive into: tinyurl.com/sialic
6. In the autochthonous MPA/DMBA model, a model of luminal B breast cancer, removing sialylation from the equation broke the cancer's hardwired resistance to immunotherapy.
To our knowledge, that's unprecedented in this model.
Overall, removing sialylation from mammary epithelium was well tolerated, yet it rendered breast cancer cells vulnerable to immunotherapy.
A compelling therapeutic window and a strong rationale for targeting tumor hypersialylation in breast cancer.
🚨 PhD position open! 🚨
Join our team at the Medical University of Vienna to study glycan regulation in mammary organoids, milk, and breast cancer.
Details in the image – please share! 🧬✨
Feeling honored to work in a lab with two (!) of 2024’s most cited scientists: mentor Josef Penninger🧠and lab colleague Max Kellner 📚 (@clarivate). Max (spot him sitting behind me in yesterday’s lab meeting) is a PhD student 🤯 @penningerlab
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Did you know? Glycans—complex sugar structures—decorate almost every protein processed by the ER/Golgi. These N-glycans coat our cells, playing critical roles in cell interactions and immune processes. 🍬
Curious about how they vary?
Let’s dive in!
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In our paper, we showcase a scalable, LC-MS/MS data-driven method combining automated ID, non-targeted profiling, and isomer-sensitive glycan analysis. Dive into the details: nature.com/articles/s41467-0…
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Great collaboration between @BOKUvienna , @IMBA_Vienna , @MedUni_Wien , and @UMich ! Thank you, J. Helm and the amazing @JohStadlmann Lab for taking me on this ride!! Together, we’re uncovering new insights into glycans. 🟦 🟡 🔺 🟢 🔶 🟨