Group Leader @BabrahamInst. He/him. All things #ubiquitin #proteostasis #proteomics #ageing #senescence. Spend too much on food & wine. Opinions mine, all mine!
Cambridge, UK
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Congrats to Devinda for passing her PhD viva with flying colours!
Massive thanks to examiners Cleo Bishop and Angeleen Fleming for an “intense but fun” experience.
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Samant Lab #preprint no. 4: “Ubi-SCAPE enables deep exploration of the poly-ubiquitylome” biorxiv.org/content/10.64898… 🧵 to follow soon—but check it out in the meantime! #proteomics #TeamMassSpec
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Thanks for letting a #Proteostasis geek gatecrash the #ICSA2025Rome party!
Day 3 began with Session 7 at #ICSA2025Rome: exploring senescence pathways from mechanisms to therapeutic opportunities.
A strong finish to the scientific program!
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We're recruiting a Research Assistant (new grant--details to follow!)--come help us work with primary human patient material to make cool 2D/3D co-culture systems, & learn more about how #proteostasis & #senescence play together in these contexts: babrahaminstitute.livevacanc…
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Back to @EdenProject for the first time in over a decade. Really enjoyed the Invisible Worlds exhibition in the Core.
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Really chuffed to be hosting my PhD supervisor, Paul Workman, for the Babraham Distinguished Lecture today.
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Successful final morning in Heraklion: found bougatsa, strong coffee, and The Great Gatsby in Greek.
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Enjoying some post-#earthquake downtime at the final day of a fantastic (and intense!) @EMBO Workshop on Protein Quality Control.
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First Lab Retreat (@wellcomegenome), followed be Christmas lunch @RedLionHinxton, marking 5 years since kick-off. I had a lot of fun, at least! Merry Christmas everyone. @BabrahamInst
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Common cidre-decanting solution in Madrid? Or reserved for the most incompetent-looking customers?
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Incredibly privileged tonight to have post-formal dinner coffee in the room where many of the #DDay plans were made @stjohnscam. joh.cam.ac.uk/pivotal-role-p….
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Yes, strong @UK_proteostasis representation in Madrid next month—not too late to submit an abstract!
If you're interested in attending another conference after our first meeting next week, there are still spots available at the Molecular Chaperones in Cancer and Protein Quality Control meeting in Madrid! 🇪🇸 (June 10-12th)
More details via the website: emedevents.com/c/medical-con…
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And thanks to Noel et al. @interherence for the Christmas goodies (yes it was sitting in UK Customs for two months; but I'm sure espresso matures with age...). Much appreciated!
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We’re hiring a postdoc!
babrahaminstitute.livevacanc…
Really cool starting point for this project (ubiquitin/proteostasis/ageing/yeast—contact me!), with the chance to tap into the know-how of super proteostasis labs next door (@DellaDavid_Lab @Ian_J_McGough @FloreyLab @t_rayon). 1/2
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“The onset of skeletal muscle decline begins around the age of 30…” Quick—where’s that New Year’s Resolutions list? royalsocietypublishing.org/d…
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Another day, another @FrydmanLab alumni pizza catch-up.
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Fantastico #PROGENIE retreat. Thanks so much Paolo @grumati for hosting in gorgeous Pozzuoli, and everyone for a great three days of data & discourse. Going to be a hard act to follow next year! #proteostasis
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@SamantLab Christmas dinner—with @HarveyEJohnston & Ruth as the most warm & generous hosts. Perfect night for blurry photos. Thanks to alumni & better halves for joining, too!
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Publisher’s complimentary PHYSICAL copy of a text book? Well I never, @RoySocChem! Introduction by @balchin_david, Mauricio Aguilar Rangel, & me—but the meat of the book is in all the chapters that follow. Thanks to the editors for their hard work (& for inviting our chapter).
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A fun visit to @ZoologyMuseum for the first time since undergrad years! Especially enjoyed the ex-eagle.
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Finally got the full house of #ubiquitin linkage peptides for some targeted proteomics. Let the absolute quantification commence! #TeamMassSpec
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Cover image made it to @molcellprot! Take that, C-minus in year 9 art class. mcponline.org/issue/S1535-94… #proteomics #hsp90 #SciArt
New pre-print! TL;DR: We used SEC-MS #proteomics to figure out global changes to protein complex profiles following HSP90 inhibition in human (HT29) cells, and found some new HSP90-dependent proteins. You can explore the data at bioinformatics.babraham.ac.u…. Short🧵to follow. 1/n
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Impromptu Sunday roast: spiced leg of lamb—Sikanderi raan—from Ammu by @Asma_KhanLDN. Ran out of ghee, so used goose fat to finish. It was…rich… but that’s lunch sorted for the week! Yum.
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Looking forward to a fun joint lab meeting with Cleo Bishop @blizard_inst. Let the proteostasis—senescence conversations commence!
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Two weeks relaxing and regenerating in California comes to an end. Ready for some exciting science at the other end of this flight ✈️
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Yasmeen (#twitterlessBeforeItWasCool), @Stephen57811302, & I wrote a chapter discussing more recent evidence for dysregulated proteostasis as a feature of ageing. Tried to be inclusive of all model organisms! Thoughts encouraged—but pay-walled… doi.org/10.1016/B978-0-323-9…
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Obligatory photo from traditional lab Christmas Thai curry. Hope everyone’s having a great festive period!
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