Computational oncology, cancer genome scientist, single cell dynamics, Memorial Sloan Kettering Cancer Center. Views are my own.
New York, NY
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Very proud and excited to see this study published today with @DmitriyZamarin and @TeamOvary_MSK
nature.com/articles/s41586-0… @Nature with N&V summarizing the study here by Drs. Denarda Dangaj Laniti and George Coukos: nature.com/articles/d41586-0…
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Sohrab Shah retweeted
Excited to share that our review on the clinical implications of CIN is out! This is particularly relevant for our patients with high grade serous ovarian cancer. @TeamOvary_MSK @ocrahope
Chromosomal instability is present in 60–80% of cancers, but isn’t targeted by current treatments. In @NatRevClinOncol, Emerging Leader Award winner @Samuel_Bakhoum highlights recent advances that could lead to therapies for difficult-to-treat cancers. nature.com/articles/s41571-0…
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Sohrab Shah retweeted
I thought my 2 year old was going through a sleep regression at 5 am, but no, he just wanted to let me know that our lab's newest work with @SohrabShah and led by Minsoo Kim was finally online @NatureGenet nature.com/articles/s41588-0…
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Sohrab Shah retweeted
Multimodal transformer-based learning infers Oncotype DX Recurrence Score from H&E images and text reports across >5000 patients from 3 cohorts. Excited to drop the preprint from this collab with @SohrabShah @jnkath @ElNahhasOSM @antoniomarraMD 🇺🇸🇮🇹🇩🇪 biorxiv.org/content/10.1101/…
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Great opportunity!!
The @LaughneyLab and @WeillCornell is recruiting innovative postdocs with expertise in variational inference, dynamical systems, and/or computational systems biology to study inter-cellular communication in the tumor microenvironment! Pls RT, job posting: laughneylab.com/join-the-tea…
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Sohrab Shah retweeted
Hear about the latest developments in #singlecellbiology from a panel of experts @CellSymposia #CSSingleCells23. Early registration ends June 16. Register today: hubs.li/Q01T6rtN0
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Congratulations Duaa! It’s a joy to work with you and this is thoroughly deserved!
Thrilled and humbled to be a recipient of a ASCO Conquer Cancer Foundation YIA award. Grateful for the opportunity to investigate the nearly events in #ovariancancer. Thankful for my mentors @SohrabShah @Samuel_Bakhoum @KaraLongRoche Carol Aghajanian. @TeamOvary_MSK
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Exciting and groundbreaking work @peter_j_park and @jakelee0711 . We're thrilled you have decided to continue your science here @CompOncMSK and look forward to welcoming you into the lab very soon!
Beautiful story @nature from @peter_j_park and @jakelee0711 showing how mis-repaired breaks from Estrogen Receptor binding lead to translocations -> dicentric #chromosomes -> bridge formation -> #ecDNA -> oncogene amplification in #Breastcancer
nature.com/articles/s41586-0…
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Huge thank you @PapaemmanuilLab for chairing this inspiring symposium. To all the Emerging Leaders: we look forward to working with you in the future. Does 'phenotype' absence in the word cloud inferred from the talk transcripts reflect where we need to focus in this field?
It has been a blast and honor to host the @CompOncMSK Emerging leaders symposium, meet our awardees & celebrate the way computational oncology is pushing our understanding of cancer biology and informs
future practices in clinical oncology. @MSKCancerCenter
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Sohrab Shah retweeted
Excited to share our work on #mRNAvaccines in #pancreaticcancer @Nature in a trial led by @TheVinodLab, @EileenMOReilly & the incredible team @MSKCancerCenter:
nature.com/articles/s41586-0…
Check out the epic tweetorial by @TheVinodLab 👇👇👇 - some thoughts below as well...
1. ENTER #mRNAvaccines for #pancreaticcancer! Long-term #PDAC survivor story PART3.
"Do #PDACs REALLY have vaccine neoantigens (NAs)"? (aren’t they lowly mutated?)
If each patient = own NAs, how do you vaccinate?
Maybe mRNA? But how?
@Nature nature.com/articles/s41586-0…
👇🏽 [1/32]
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Congrats Nicky and team!
Our paper together with @SwantonLab @CharlesSwanton ‘Genomic-transcriptomic evolution in lung cancer and metastasis’ comes out today @Nature. nature.com/articles/s41586-0… Read all about it 🚨👇 1/9
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Congratulations Adam! So well deserved!
Excited to announce I received an F31 award from
@theNCI! This supports my PhD training in @SohrabShah’s lab developing computational methods to study DNA replication in genomically unstable cancers. Thanks to @cbm_student, @CompOncMSK & many others for your support
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Very excited to launch this new partnership with the #MERIT program @MSKEducation and @CompOncMSK to support early career scientists in the field of computational oncology. Our field needs diverse perspectives and scientists from diverse backgrounds to be strong!
We're thrilled to announce our new training opportunity for computational postdocs striving to improve & accelerate cancer research @MSKCancerCenter- The Henry and Alexia Fernandez Computational Oncology Fellowship! Learn more: tinyurl.com/mskcofellow
#ResearchDiversity #compbio
ALT The Henry and Alexia Fernandez Computational Oncology Fellowship is designed as a postdoctoral fellowship and will support individuals for 3 years by providing: Research guidance and mentorship for computational scientists striving to improve and accelerate cancer research at MSK. Guided training and professional development to successfully pursue faculty roles and establish independent laboratories to advance scientific discovery and patient care in the next decade and beyond. Benefits include a competitive salary starting at $67,470 + health benefits; a moving allowance (up to $3,000); access to MSK rental housing for up to 3 years; and a yearly provision to present at scientific conferences. Who should apply? This innovative opportunity aims to support outstanding postgraduate-level scientists from racial, ethnic, and other underrepresented groups in biomedical sciences who are committed to an academic career at the intersection of cancer and computational biology.
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Sohrab Shah retweeted
Interested in gaining research experience before #gradschool? Consider our #postbac program - the MSK Bridge! Join @MSKEducation for a live info session next month, Jan 12 @ 12 pm EST or Jan 19 @ 3 pm EST.
Register: tinyurl.com/MSKBridgeInfoSes…
#PrePhD #PreMDPhD #AcademicTwitter
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This was a huge team effort and I want to congratulate all of the authors from several departments at Memorial Sloan Kettering. Special acknowledgment to the two 1st authors @ivazquezgarcia and @fuhlitz for sterling work on this study.
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Thank you to the patients for consenting to the research, as well to different organizations that have funded different parts of the program: @ocrahope , @CancerGrand , the Les Lois Shaw Foundation and the DoD CDMRP.
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The Computational Oncology program @CompOncMSK , where a large piece of the research took place, is supported by @Cycle4Survival and we could not be more grateful for this support!
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Very proud and excited to see this study published today with @DmitriyZamarin and @TeamOvary_MSK
nature.com/articles/s41586-0… @Nature with N&V summarizing the study here by Drs. Denarda Dangaj Laniti and George Coukos: nature.com/articles/d41586-0…
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This led to uncovering highly specific immune evasion mechanisms as a function of the mutational process.
Site of disease also plays a role in immune cell states.
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What did we find?
Mutational processes are key factors in shaping the immune response in ovarian cancer. We ’subtyped’ the tumors using the pattern of mutations in whole genome sequencing and compared their cell intrinsic and cell extrinsic properties.
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Given that disease is often widespread we also were careful to sample other intra-peritoneal sites of these patients to enable primary-metastatic comparisons.
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