Driving discoveries and innovative treatments for childhood cancer and other diseases. Ranked #3 by USNWR. #StJude #StJudeResearch
Memphis, Tenn.
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St. Jude scientists identified a direct role for PARP1 in chromatin remodeling, revealing for the first time how the protein partially disassembles nucleosomes to make damaged DNA accessible for repair. The findings could lead to more targeted PARP1 inhibitors and potentially reduce treatment toxicity. bit.ly/4zRmFDb
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St. Jude is offering a free livestream of the @NatureConf, “Accelerating Pediatric Cancer Innovation: From Research to Real-World Impact,” Nov. 11-12. Join from anywhere in the world and hear from a global community dedicated to advancing pediatric cancer care.
Register to watch: bit.ly/4spM3NO
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Researchers identified a potential therapeutic vulnerability in a subset of osteosarcoma. In preclinical models, combining EP300 degradation with AKT inhibition slowed tumor growth and prolonged survival. The findings suggest a potential path toward more personalized treatment. bit.ly/3U3DwDt
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Aseem Ansari, PhD, St. Jude Department of Chemical Biology & Therapeutics chair, will present Thursday in The Science of Childhood Cancer virtual lecture series. He will share how cell surface receptors can directly regulate genes in the nucleus and what it means for future therapies.
Register for his talk today: bit.ly/4hkFOHz
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Charles W.M. Roberts, MD, PhD, and Carsten Bönnemann, MD, habil., have been elected to the @theNAMedicine, one of the highest honors in health and medicine. Their election recognizes contributions advancing scientific understanding and improving patient care.
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Roberts, St. Jude president and CEO-elect, was recognized for advancing understanding of how disruptions to chromatin remodeling complexes contribute to cancer, helping lay the foundation for new FDA-approved and investigational therapies. bit.ly/4iuc6ji
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Bönnemann was recognized for his contributions to precision medicine for neurogenetic and neuromuscular disorders. His work has advanced understanding of the genetic causes of diseases such as juvenile ALS and congenital muscular dystrophy while helping drive novel therapeutic approaches. bit.ly/480lfdp
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Research from Suzanne Baker, PhD; Stacey Ogden, PhD; Lindsay Schwarz, PhD; and Jay Bikoff, PhD, reveals how development shapes brain tumors, organ formation, anxiety and movement, connecting molecular and cellular mechanisms with disease and potential therapeutic targets.
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Schwarz mapped a stress-related brain circuit linking C1 neurons to a key brain region. Prolonged activation produced lasting anxiety-like behavior, while inhibition reduced it. bit.ly/4ycfmph
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Bikoff linked a subgroup of spinal neurons, V1Pou6f2, to the speed of rhythmic movement. Loss of these neurons slowed locomotion without disrupting limb movements. bit.ly/4g1d58f
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A study by St. Jude scientists showed childhood cancer survivors living in the most vulnerable neighborhoods had twice the chronic disease burden of those in the least vulnerable areas. The findings highlight the need to integrate neighborhood-level factors into survivorship care. bit.ly/47T5i8L
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This week in The Science of Childhood Cancer virtual lecture series, Tara Henderson, MD, MPH, FASCO, @YaleMed, will discuss survivorship science and strategies to improve lifelong outcomes for pediatric patients.
Join us for this week’s lecture: bit.ly/4hkFOHz
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By building one of the most comprehensive datasets of neuroblastoma samples, St. Jude researchers and collaborators identified a gene expression signature that distinguishes high-risk, treatment-resistant neuroblastoma cells from lower-risk cells. The finding improves the ability to study disease linked to poor outcomes and provides new patient-derived models to help evaluate potential treatment strategies. bit.ly/4hDnGIM
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St. Jude Research retweeted
Join us Nov. 10 to learn about the Applied Biomedical Data Sciences master’s program. Hear from academic recruiters, program leaders and students, and discover how the program prepares graduates to tackle complex biomedical challenges through data-driven approaches.
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The 2026 Bringing Chemistry to Medicine symposium brought together more than 1000 attendees from 63 countries, both in Memphis and virtually. Hosted by St. Jude in collaboration with @CellPressNews, the event convened global experts in chemical biology and transcription-targeted therapeutics to advance innovation in biomedical science.
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Looking to expand your perspective on pediatric cancer research? Hear why postdoctoral research associate Tuyu Zheng, PhD, recommends The Science of Childhood Cancer virtual lecture series for trainees and early-career researchers.
Join upcoming lectures through Nov. 19: bit.ly/3TD4Rvy
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St. Jude researchers attended the @AACR Special Conference in Cancer Research which focused on bridging discovery and clinical impact in pediatric cancer. Charles Mullighan, MBBS, MSc, MD, gave the keynote address on working toward a cure for acute leukemia through the lens of genomics.
Among those sharing advances in pediatric cancer in plenary sessions were Noha Shendy, PhD; Mark Hatley, MD, PhD; and Alejandro Gutierrez, MD. Shendy, Grace McKay-Corkum, MD, and Mohammad Ali Mohammad Nezhady, PhD, also presented abstracts.
#AACRpediatric26
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