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Really excited to share my first paper from the @JohnWhitneyIIDR lab, alongside an amazing grad student, Polina. We identify a chaperone family required for the folding of a domain of T7SS toxins, and solve the structure of the chaperone-toxin complex. pnas.org/doi/10.1073/pnas.25…
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Stephen Garrett retweeted
Excited to share our latest work with @AlbertoMarina14 and @AvigdorEldar labs, where we decipher the mechanism by which SPβ-like phages sense the SOS response to control the lysis–lysogeny switch. biorxiv.org/content/10.1101/…
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Stephen Garrett retweeted
academic.oup.com/nargab/arti…
Exciting to see a plethora of toxin/antitoxin systems (e.g., retrons, type II) identified in P. aeruginosa genomic islands with limited representation in DefenseFinder, etc.
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Stephen Garrett retweeted
🚨PhD Opportunity Alert🚨 Join me,@DrSuzieHumphrey and Donal Wall to investigate how environment shapes anti-phage defences & prophage–prophage conflict in Pseudomonas aeruginosa. Apply here: gla.ac.uk/postgraduate/docto…
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Stephen Garrett retweeted
Latest BREX story from the lab - turns out there is a nuclease after all! Congrats to Jenny Readshaw and the whole team, including wonderful collabs Barry Stoddard, Brett Kaiser and @DarrenSmithdx. @NAR_Open @NEBiolabs @DurBiol academic.oup.com/nar/article…
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Stephen Garrett retweeted
New preprint from @MacBiochemGrad and @McMasterMDPhD student @JakeColautti and @BBS_McMasterU and @McMasterIIDR Postdoc @StephenRG97!
Proteolytically activated antibacterial toxins inhibit the growth of diverse Gram-positive bacteria biorxiv.org/content/10.1101/… #biorxiv_micrbio
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Stephen Garrett retweeted
A broad-spectrum, contact-independent antimicrobial that is neither a nonribosomal peptide nor a BGC- assembled small molecule from @JakeColautti @StephenRG97 @JohnWhitneyIIDR
Proteolytically activated antibacterial toxins inhibit the growth of diverse Gram-positive bacteria biorxiv.org/content/10.1101/… #biorxiv_micrbio
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Stephen Garrett retweeted
.@jrpenades (@imperialcollege) and colleagues published a new review on #phage satellite genetics, ecology and #evolution, diving into how these elements impact bacterial evolution and virulence.
buff.ly/GTeAxVg
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Some really cool work from @JakeColautti in the @JohnWhitneyIIDR lab on a family of contact-independent, broad spectrum protein toxins that target Gram-positive bacteria.
Proteolytically activated antibacterial toxins inhibit the growth of diverse Gram-positive bacteria biorxiv.org/content/10.1101/… #biorxiv_micrbio
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Stephen Garrett retweeted
And here it is, the completed BASEL collection finally published as early access in @PLOSBiology - see the thread for more details. 🤗🧬🎣
🚨 🧬 Updated preprint on the completed BASEL collection - what's new? Some fun with bacterial immunity and a new P22 relative infecting E. coli K-12. A thread 🧵
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RT @GiusyM1990: Pleased to share that my main Sir Henry Wellcome Fellowship project is now published! This study provides mechanistic insig…
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Stephen Garrett retweeted
We have extended the deadline for this! If you are passionate about phage-bacteria interactions, check this out and join us!
🚨We are hiring! A MRC-funded PDRA position to study novel anti-phage systems & their evolutionary dynamics in P. aeruginosa, in collaboration with @friendlymicrobe. If you are passionate about phage-bacteria interactions & evolution, apply now ! tinyurl.com/bddz4z44
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Stephen Garrett retweeted
Nanopore sequencing-based measurement of paramyxovirus RNA editing reveals virus-specific differences in editing efficiency of mRNA, ... biorxiv.org/content/10.1101/… #biorxiv_micrbio
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Stephen Garrett retweeted
The lab is now up and running at New England Biolabs @NEBiolabs! I'm looking for a postdoc to study phage defence systems. If you'd like the academic freedom to publish but the resources of industry, then take a look 🤓😃 neb.wd5.myworkdayjobs.com/en…
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Stephen Garrett retweeted
Love phage-bacteria interactions, anti-phage systems, and a sprinkle of evolutionary biology? There’s still time to apply and join our team in Glasgow at @UofGSii !
🚨We are hiring! A MRC-funded PDRA position to study novel anti-phage systems & their evolutionary dynamics in P. aeruginosa, in collaboration with @friendlymicrobe. If you are passionate about phage-bacteria interactions & evolution, apply now ! tinyurl.com/bddz4z44
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Stephen Garrett retweeted
Latest out from the lab. Crazy amounts of #diversity in #T6SS #effectors #pseudomonas out now in @NatureComms @MPI_EvolBio @ImperialNHLI
imperial.ac.uk/news/260613/b…
evolbio.mpg.de/3804447/same-…
nature.com/articles/s41467-0…
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Stephen Garrett retweeted
Super opportunity to join Giusy in Glasgow!
🚨We are hiring! A MRC-funded PDRA position to study novel anti-phage systems & their evolutionary dynamics in P. aeruginosa, in collaboration with @friendlymicrobe. If you are passionate about phage-bacteria interactions & evolution, apply now ! tinyurl.com/bddz4z44
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Stephen Garrett retweeted
EMBO Postdoctoral Fellowships support internationally mobile postdoctoral researchers in Europe and around the world. Apply here (next cut-off date is 14 February):
embo.org/funding/fellowships…
#ResearchFunding #LifeSciences
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Stephen Garrett retweeted
The final version of our Serratia paper is now out! Congrats to @TomCX99 and (X-less) Suraj, and a big thank you to @BlowerLab and @StephenRG97. tinyurl.com/3vnyvufa
New pre-print from the lab, led from (for now Twitter-less) star-RA Tom Cummins. If you did receive his PhD application, you do not want to miss this chance, Tom is a star!
As always, fun collaboration with the amazing @BlowerLab and @StephenRG97
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