Pediatric Infectious Disease physician researching effects of inflammation on hematopoietic stem cells; Advisory Board, Doctors for Change
Houston, TX
Based in United States
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Katherine King MDPhD retweeted
Microbes support normal blood production! Authors in this recently published article report on the microbes and microbial metabolites missing from pediatric patients with antibiotic-associated neutropenia. @TheKingLab 👉bit.ly/4fUXyWe
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Katherine King MDPhD retweeted
Confused about possible biomarkers for blood cell aging? Check out this review by Wolfgang Wagner, including exploration of how transferable such markers are between mice and humans - Experimental Hematology exphem.org/article/S0301-472… @ISEHSociety @ELShematology
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A great collaboration with @baldridge_lab @WUSTL and Ritu Banerjee @VUMCchildren. Congrats to Josie Fernandez Sanchez who spearheaded this work and @ArushanaMak03 HannahYan Jeremy Schraw Rachel Rodgers and many more who contributed to this work @Hemasphere_EHA
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In future work we hope that we can use some of these metabolites to rescue antibiotic- associated neutropenia, making antibiotics safer to use.
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Stool metabolomics revealed a number of differentially abundant metabolites including members of the uridine synthesis pathway.
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Amazingly, those who developed neutropenia had depletion of a specific class of microbiota: Lachnospiraceae. These bacteria have been reported to impact outcomes from HSCT and to be significant producers of short chain fatty acids.
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Patients on longer courses of antibiotics, especially IV antibiotics, and with ICU stays were more likely to get neutropenia.
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We enrolled pediatric patients @TexasChildrens and @VUMCchildren and collected stool samples at the start and end of prolonged antibiotic courses (2 weeks or more) 💩
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It’s here! Our first actual clinical study re: #microbiota changes in antibiotic-associated neutropenia. onlinelibrary.wiley.com/doi/… @TCHResearchNews @CAGTHouston @BCMFromtheLabs @BCMPedIDFellows
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