October issue
@TransplantJrnl
◼ From Gene-Editing to Exogenesis: Pigs as a Source of Immune-Compatible Organs for Transplantation
◼ Organ Assessment and Repair Centers: Navigating Practical Hurdles in a New Era of Transplantation
And More bit.ly/TPAissue
Moving normothermic liver perfusion into the OPO: fewer turndowns, more DCD livers used, and 94.6% 1-year survival at a partner center. A scalable, sustainable, equitable model for expanding access to liver transplantation. #TXPforAll#Transplantationtinyurl.com/4ywsucv8
This study puts long-term ex situ preservation to the test using normothermic machine perfusion (NMP) on a standard, commercially available OrganOx Metra—no hardware modifications needed. #TXPforAll#Transplantation#OpenAccesstinyurl.com/24es7hmt
This paper summarises the highlights of the 5th Summit on Stem Cell-Derived Islets, which showcased significant progress in islet biology, immunoprotection, scalable manufacturing and clinical transplantation. #TXPforAll#Transplantation#OpenAccesstinyurl.com/yx2bazz3
This review addresses the question of whether Regional Organ Assessment and Repair Centres could help to unlock more and better donor organs. #TXPforAll#Transplantationtinyurl.com/mrnzkmwf
🌍 A global analysis of LT activity vs. cirrhosis burden (2000–2023) reveals a striking mismatch: LT is concentrated in high- sociodemographic Index (SDI) countries, while low-SDI countries have very limited access and rely heavily on living donors. tinyurl.com/4y4p8bka
#TBT to this week's featured top downloaded paper from 2024:Anti-CD38 Monoclonals for Treatment of Antibody-mediated Rejection in Renal Allografts #Transplantation#Medtinyurl.com/4uc54d4b
This review reports on the use of functional and molecular biomarkers during machine perfusion to assess graft quality in real time, and emphasises the need for validated, standardised tools to improve outcome prediction. #TXPforAll#Transplantationtinyurl.com/4sew3sz5
This review explores the potential of combining donor and recipient genetics to advance precision transplantation using polygenic risk scores, while highlighting the key challenges to clinical implementation. #TXPforAll#Transplantationtinyurl.com/2tm4c7ca
#TBT to this week's featured top downloaded paper from 2024: Functional Natural Killer-cell Genetics and Microvascular Inflammation After Kidney Transplantation: An Observational Cohort Study #Transplantation#Medtinyurl.com/4bab76n5
🌍 A global survey across 64 countries highlights the scale and complexity of international travel for organ transplantation (ITOT) and the need for stronger data, governance and equitable access. #TXPforAll#Transplantation#Organdonatiotinyurl.com/2z379usk
#TBT to this week's featured top downloaded paper from 2024:Promoting Equitable and Affordable Patient Access to Safe and Effective Innovations in Donation and Transplantation of Substances of Human Origin and Derived Therapies #Transplantation#Medtinyurl.com/yu6dsep3
🫁 Promising findings in lung transplantation: S1PR1 activation with CYM5442 during EVLP reduced pulmonary edema, lung weight gain, pressures, and inflammatory mediator release while preserving endothelial integrity. #TXPforAll#Immunology#Transplantationtinyurl.com/36jts4m3
Exciting Results: In 204 HCV-negative recipients of kidneys from HCV-viremic donors, 7-day sofosbuvir/velpatasvir prophylaxis resulted in 100% overall SVR12 after retreatment, with excellent 1-year patient and graft survival. #TXPforAll#Transplantationtinyurl.com/3m32prtb
#TBT to this week's featured top downloaded paper from 2024:Use of Ex Situ Machine Perfusion for Liver Transplantation: The National Experience #Transplantation#Medtinyurl.com/4ytjy9u7