UF Health Cancer Institute researchers recently developed an innovative technology that allows researchers to study cancer cell growth in a more realistic tissue-like environment. The work was featured on the cover of the journal Advanced Materials Technologies, recognizing the innovation and broad impact of the technology.
The team, led by
@UF_HE_LAB, developed a high-throughput technology that rapidly generates thousands of uniform collagen microbeads. The platform creates miniature three-dimensional environments that better mimic how tumor cells grow in the body than traditional flat cell culture systems.
Using lung cancer and normal lung cells, the team showed that these collagen microbeads support the formation of 3D tumor spheroids, which researchers can use to study cancer cell growth.
The platform can be scaled to produce numerous consistent 3D tumor models, making it useful to evaluate anti-cancer therapies. It has the potential to be used to test new treatment strategies.
The collagen microbeads also support long-term cell growth and extracellular vesicle (EV) production. EVs are small particles released by cells that help cells communicate and may serve as biomarkers or therapeutic agents.
Because the system is built from natural collagen, the major structural protein found throughout the body, it creates a biologically relevant microenvironment that can be adapted for cancer research, regenerative medicine and drug development.
Samantha Ali, a graduate student in He's lab in
@UFPharmacy, is the study's first author. Lizi Wu, Ph.D., co-leader of the UF Health Cancer Institute's Mechanisms of Oncogenesis research program, is also a co-author.
Read the full paper:
doi.org/10.1002/admt.2025022…
ALT The cover of the journal Advanced Materials Technologies with large colorful 3D molecules.