Assistant Professor @uofg | Biochemist | Structural Biologist | Mass spectrometry | NMR spectroscopy
Guelph, ON, Canada
- Tweets 729
- Following 420
- Followers 510
- Likes 917
Pinned Tweet
1/🧵Human ClpP protease is targeted in cancer therapy with the activator ONC201 @chimerix Yet all structures of ClpP have captured it in its inactive state, even when bound to activators! ClpP is paradoxically activated by inhibitors at low concentrations before inhibition starts
4
6
21
2,755
Vahidi Lab@UofGuelph 🇨🇦 retweeted
Please share:
Hot off the press in NAR @OxfordJournals
We solve the structure of the elusive “pixel” domain within human PML protein that looks like a nuclease but is not.
Very proud of this collaboration with the Weller and Hao labs at UConnHealth.
academic.oup.com/nar/article…
6
23
1,474
Allosteric inhibition of human mitochondrial ClpP by hijacking the dordaviprone (ONC201) binding site: nature.com/articles/s41467-0…
1
5
113
Vahidi Lab@UofGuelph 🇨🇦 retweeted
Allosteric inhibition of human mitochondrial ClpP by hijacking the dordaviprone (ONC201) binding site: nature.com/articles/s41467-0…
5
14
1,648
Vahidi Lab@UofGuelph 🇨🇦 retweeted
#UofT researcher Lewis Kay awarded 2026 Royal Medal by U.K.'s Royal Society 🏆 uoft.me/cCu
ALT Image shows Lewis Kay
1
13
41
4,935
Vahidi Lab@UofGuelph 🇨🇦 retweeted
📢CONGRATULATIONS TO DR. MADISON TURNER on successfully defending her thesis on "Allosteric regulation of the Mycobacterium tuberculosis proteasome"👏👨🎓🥂🎉
🗓️August 20th
🔬Vahidi Lab
1
1
82
Vahidi Lab@UofGuelph 🇨🇦 retweeted
📢CONGRATULATIONS TO DR. BRADLEY DAVIS on successfully defending his thesis on the "Substrate engagement mechanism of the bacterial proteasome activator Bpa"! 🎉👏🥳
🗓️August 13th
🔬Vahidi Lab
1
1
64
Vahidi Lab@UofGuelph 🇨🇦 retweeted
📣CONGRATULATIONS TO DR. MONICA GONCALVES on successfully defending her thesis on "Mechanisms of allosteric regulation in human mitochondrial ClpP protease"!👏👏🍾🎉
🗓️August 25th
🔬Vahidi Lab
1
1
106
Vahidi Lab@UofGuelph 🇨🇦 retweeted
SickKids' Sr. Scientist Dr. Lewis Kay has received a prestigious 2026 Royal Medal from The Royal Society.
In a new Q&A, Dr. Kay opens up about his journey, priorities and legacy ⬇️
sickkids.ca/en/news/archive/…
3
11
1,604
Vahidi Lab@UofGuelph 🇨🇦 retweeted
📣CONGRATULATIONS TO JACQUELYN OGATA-BEAN on successfully defending her thesis on "De novo design and characteri-589! of human mitochondrial ClpP activators"!👏👏🍾🎉
🗓️August 18th
🔬Vahidi Lab
1
1
93
Vahidi Lab@UofGuelph 🇨🇦 retweeted
After a while not posting, happy to share our latest paper on how the different J-domains interact with the various HSP70s! Proud of Roni and of the outcome🏆 @PNASNews
pnas.org/doi/10.1073/pnas.25…
11
41
3,578
Vahidi Lab@UofGuelph 🇨🇦 retweeted
#UofT Professor Raquel Urtasun and John Rubinstein, senior scientist at @SickKidsNews and professor at @uoftmedicine, have been elected 2026 Fellows of the @royalsociety, the U.K.'s national academy of sciences uoft.me/czY
3
7
1,385
Vahidi Lab@UofGuelph 🇨🇦 retweeted
The ubiquitous biology of intracellular protein degradation: a tribute to Alfred L. (“Fred”) Goldberg. The review articles in this series highlight key areas shaped and inspired by his enduring contributions.
jbc.org/thematic-the-ubiquit…
1
7
808
Vahidi Lab@UofGuelph 🇨🇦 retweeted
Researchers at the University of Guelph & University of Toronto, led by Siavash Vahidi @VahidiLab and Lewis E. Kay @LEK_Lab together with Waters Corp, used NMR to identify a potential drug target in the tuberculosis stress-response system news.uoguelph.ca/2026/06/u-o… #NMRchat #NMR 🧲
1
7
373
Vahidi Lab@UofGuelph 🇨🇦 retweeted
CONGRATULATIONS to our Phillips Scholarship Winners, Nicholas Gervais (Shapiro Lab) and Bradley Davis (Vahidi Lab)!!👏👏👏🎉🥳🎈
1
1
188
Vahidi Lab@UofGuelph 🇨🇦 retweeted
Can enzymes retain catalytic activity in the gas phase? Using tandem MS, molecular dynamics simulations, and enzyme variants courtesy of the @VahidiLab, Kirsty (@kirstynyk) uncovers new insight towards this question.
Now published in JACS (@J_A_C_S)!
pubs.acs.org/doi/10.1021/jac…
8
14
2,502
Vahidi Lab@UofGuelph 🇨🇦 retweeted
CIHR funding rate: 13.6%.
Early 2000s: 30%+.
Canada’s new $1.7B Impact+ program recruits talent — but without increased Tri-Council base funding, we risk further strain on an already stretched system.
We’re calling for $1B over 5 years.
Support here: tinyurl.com/33c5av46
1
52
135
12,133
Vahidi Lab@UofGuelph 🇨🇦 retweeted
Molecular mechanisms of mitochondrial AAA+ proteases - Journal of Biological Chemistry jbc.org/article/S0021-9258%2…
1
3
218
Vahidi Lab@UofGuelph 🇨🇦 retweeted
Join 2026 BPS Lecturer Lewis Kay on Tuesday, February 24, 2:00 PM - 3:00 PM at #bps2026 for an informal discussion. Dr. Kay will share insights from his scientific career—from pioneering discoveries to lessons learned along the way—and reflect on how the field continues to evolve
3
7
609
Vahidi Lab@UofGuelph 🇨🇦 retweeted
MCB @ U of Guelph is hiring (again)! 🎉
Tenure-track Assistant Professor in Biochemistry
Part of our strategic cluster hire.
Apply now 👉 careers.uoguelph.ca/job/Guel…
#Biochemistry #FacultyJobs #AcademicTwitter #MolBio
11
14
2,693
Vahidi Lab@UofGuelph 🇨🇦 retweeted
Out in @pnas today
Showcasing the power of NMR!
NMR and enzyme kinetics show USP7 enzyme transiently sampling a low-populated active state, and its disease-causing variant enhancing these dynamics
pnas.org/doi/10.1073/pnas.24…
Stellar work by students Gabi Valles and Emilie Korchak
2
7
30
1,552