Methods for organic synthesis using new activation strategies. New reagents. Metals of all kinds. Student run.
Pittsburgh, PA
- Tweets 63
- Following 103
- Followers 182
- Likes 34
Check out the group's latest work on functionalization of medicinally relevant sulfonyl compounds under weakly basic conditions by Mike Leitch and company: chemrxiv.org/doi/full/10.264…
2
176
A mechanistic riddle solved? Maybe, with the help of @pengliu_group! Ruiqi's paper on diastereodivergence and molecularity change in iridium-catalyzed C-H functionalization is published in ACS Catalysis: pubs.acs.org/doi/10.1021/acs…
2
19
1,474
James's paper on the use of esters and imides as electrophiles for enantioselective propargylic C-H functionalization and application to UCS1025A synthesis has been published on @ChemicalScience: pubs.rsc.org/en/content/arti…
176
WangGroupPitt retweeted
Super excited to share this toolbox and it's really a great collaboration with all of my colleagues!
💊Accelerating Medicinal Chemistry💊: A C(sp3)-rich Fragment Toolbox for Redox-Neutral Cross-Coupling, appearing today in @chemrxiv: chemrxiv.org/engage/chemrxiv…
A great collaboration with brilliant drug hunters at BMS, Pfizer, and Biogen.
Quick summary: A new toolbox of 15 sulfonyl hydrazide reagents (some of which are already commercial) enables redox-neutral, nickel-catalyzed radical cross-coupling to attach small C(sp3)-rich fragments like methyl and cyclopropyl to (hetero)arenes, streamlining the hit-to-lead phase of drug discovery. These stable, easy-to-synthesize reagents require no additional oxidants, reductants, or costly catalysts, offering mild, dump-and-stir conditions and broad substrate compatibility across over 60 (hetero)aryl halides. Compared to traditional methods like Suzuki or Kumada couplings or radical couplings wedded to redox, this unified approach significantly improves yields and simplifies synthesis, accelerating analog optimization and late-stage functionalization of drug-like molecules.
2
15
1,242
Check out the group's recent work on enantioselective acetal synthesis by C-H propargylation of esters and imides by James and company, including their formal synthesis of the telomerase inhibitor UCS1025A in nine steps: pubs.rsc.org/en/content/arti…
11
161
WangGroupPitt retweeted
#ChemAsianJ #AsymmetricSynthesis of Propargylic and Allenic Silanes, Germanes, and Stannanes (Yi-Ming Wang and co-workers) • onlinelibrary.wiley.com/doi/…
2
21
1,593
A neat way of making fluorinated dienes by Yue and Aaron: pubs.rsc.org/en/content/arti…
3
137
WangGroupPitt retweeted
Modern Organometallic C-H Functionalizations with Earth-Abundant Iron Catalysts: An Update (Gianpiero Cera and co-workers) onlinelibrary.wiley.com/doi/…
1
3
23
3,159
Yue's paper (Jin and Austin as co-authors), the group's first foray into oxidative C-H functionalization and metalloradical chemistry, has been published in Angewandte:
onlinelibrary.wiley.com/doi/…
2
11
227
Congratulations to Jiao and the rest of the gang for getting this paper across the finish line! It's a fitting way to finish up his work as a postdoc in the group.
Have a safe journey back to China and best of luck in the next stage of your career!
pubs.acs.org/doi/10.1021/jac…
3
12
268
WangGroupPitt retweeted
Iridium-Catalyzed Enantioselective Propargylic C–H Trifluoromethylthiolation and Related Processes | Journal of the American Chemical Society @PittTweet @TotalSyntheses #Ir #Catalysis #Enantioselective #Propargyl #CH #Trifluoromethylation pubs.acs.org/doi/10.1021/jac…
5
46
5,052
WangGroupPitt retweeted
Excited to share our newest strategy to access carbenes from aldehydes - now via radicals!
Young & Jake found this highly practical, efficient, & selective way to make triangles - that even works in the presence of air or water!
@J_A_C_S
pubs.acs.org/doi/10.1021/jac…
12
41
352
22,503
WangGroupPitt retweeted
#Bismuth Metallomimetic chemistry!!
#Bismuth shows transition metal-like behavior, engaging in CH activation #catalysis. Now out in @J_A_C_S: pubs.acs.org/doi/10.1021/jac…. Thanks to @WangGroupPitt for taking us on this journey! @PittTweet @Uni_MR
1
5
946
A nice solution to a longstanding synthetic challenge from the Dong lab (@GBD_Lab):
pubs.acs.org/doi/epdf/10.102…
1
153
WangGroupPitt retweeted
Transition Metal Mimetic π-Activation by Cationic Bi(III) Catalysts for Allylic C–H Functionalization of Olefins Using C═O and C═N Electrophiles | JACS @Uni_MR @PittTweet #PiActivation #TM #Bi #Catalysts #Allylic #CHFunctionalization #Electrophiles pubs.acs.org/doi/10.1021/jac…
5
40
4,677
Using bismuthanes as catalysts for allylic C(sp3)-H functionalization: unexplored main-group reactivity and Bi-olefin interaction studies. Check our work on JACS: pubs.acs.org/doi/10.1021/jac…. Thank Lichtenberg lab @LabLichtenberg for a wonderful collaboration!
9
200
WangGroupPitt retweeted
Threonine Aldolase-Catalyzed Enantioselective α-Alkylation of Amino Acids by Tian-Ci Wang, Zheng Zhang, Guodong Rao, Jiedong Li, Josephine Shirah, @rdavbritt, Qilei Zhu, @yang2biocat @ucsbchemistry in @J_A_C_S pubs.acs.org/doi/10.1021/jac…
1
13
61
5,358
WangGroupPitt retweeted
We publish our second paper on pyridoxal biocatalysis in Nature: We repurposed PLP-dependent threonine aldolases to catalyze radical C-C coupling reactions that are not known in either organic chemistry or enzymology: nature.com/articles/s41586-0…
10
37
280
20,803
Today is Sarah's last day in the group. Though a sad occasion, the publication of her solo work on allylic C-H functionalization using N-containing Michael acceptors in Chem. Sci. today is cause for celebration! Congrats, Dr. Scrivener!
doi.org/10.1039/D4SC00655K
3
11
1,961